Effects of mutations within two hydrophilic regions of the bovine papillomavirus type 1 E1 DNA-binding domain on E1-E2 interaction

Journal of General Virology

Volumn 82, Issue 10, 2001, Pages 2341-2351

  Woytek, K J ^a   Rangasamy, D ^a   Bazaldua Hernandez, C ^a   West, M ^a   Wilson, V G ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN E1; UNCLASSIFIED DRUG; VIRUS E2 PROTEIN; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; EVALUATION; GENETIC CONSERVATION; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PAPILLOMA VIRUS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; VIRUS GENOME; VIRUS MUTATION; VIRUS REPLICATION;

EID: 0034789769     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-82-10-2341     Document Type: Article

References (45)

1. Amino-terminal domains of the bovine papillomavirus type 1 E1 and E2 proteins participate in complex formation
2. Functional interactions between papillomavirus E1 and E2 proteins
3. The 68-kilodalton E1 protein of bovine papillomavirus is a DNA binding phosphoprotein which associates with the E2 transcriptional activator in vitro
4. Bovine papillomavirus E1 protein binds specifically DNA polymerase α but not replication protein A
5. Bovine papillomavirus type 1 DNA replication: The transcriptional activator E2 acts in vitro as a specificity factor
6. Characterization of the DNA binding domain of the bovine papillomavirus replication initiator E1
7. Two patches of amino acids on the E2 DNA-binding domain define the surface for interaction with E1
8. Papillomavirus DNA replication
9. Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus
10. Transient viral DNA replication and repression of viral transcription are supported by the C-terminal domain of the bovine papillomavirus type 1 E1 protein
11. Biochemical and electron microscopic image analysis of the hexameric E1 helicase
12. Distinct roles of two binding sites for the bovine papillomavirus (BPV) E2 transactivator on BPV DNA replication
13. Induction of structural changes in the bovine papillomavirus type 1 origin of replication by the viral E1 and E2 proteins
14. Separate domains in E1 and E2 proteins serve architectural and productive roles for cooperative DNA binding
15. Structural and mutational analysis of E2 transactivating proteins of papillomaviruses reveals three distinct functional domains
16. Identification of a short, hydrophilic amino acid sequence critical for origin recognition by the bovine papillomavirus E1 protein
17. Interactions of the papovavirus DNA replication initiator proteins, bovine papillomavirus type 1 E1 and simian virus 40 large T antigen, with human replication protein A
18. Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain
19. DNA binding specificity of the bovine papillomavirus E1 protein is determined by sequences contained within an 18-base-pair inverted repeat element at the origin of replication
20. The bovine papillomavirus type 1 (BPV1) replication protein E1 modulates transcription activation by interacting with BPV1 E2
21. Isolation of an amino-terminal region of bovine papillomavirus type 1 E1 protein that retains origin binding and E2 interaction capacity
22. Formation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1
23. The bovine papillomavirus E2 protein modulates the assembly of but is not stably maintained in a replication-competent multimeric E1-replication origin complex
24. E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: Transactivation is mediated by the conserved amino-terminal domain
25. The papillomavirus E2 regulatory proteins
26. Reconstitution of a functional bovine papillomavirus type 1 origin of replication reveals a modular tripartite replicon with an essential AT-rich element
27. Contribution of bovine papillomavirus type 1 E1 protein residue 48 to replication function
28. Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator
29. Two distinct regions of the BPV-1 E1 replication protein interact with the activation domain of E2
30. The cellular DNA polymerase α-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase
31. The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain
32. Bovine papillomavirus E1 protein is sumoylated by the host cell Ubc9 protein
33. Recruitment and loading of the E1 initiator protein: An ATP-dependent process catalysed by a transcription factor
34. Transcription factor-dependent loading of the E1 initiator reveals modular assembly of the papillomavirus origin melting complex
35. Domains of the BPV-1 E1 replication protein required for origin-specific DNA binding and interaction with the E2 transactivator
36. Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro
37. The initiator protein E1 binds to the bovine papillomavirus origin of replication as a trimeric ring-like structure
38. The papillomavirus E1 protein forms a DNA-dependent hexameric complex with ATPase and DNA helicase activities
39. Bovine papillomavirus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication
40. Transactivation of a bovine papillomavirus transcriptional regulatory element by the E2 gene product
41. DNA-binding domain of bovine papillomavirus type 1 E1 helicase: Structural and functional aspects
42. Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames
43. A bovine papillomavirus E1-related protein binds specifically to bovine papillomavirus DNA
44. The E1 protein of bovine papillomavirus 1 is an ATP-dependent DNA helicase
45. Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins