Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene increases the sensitivity of esophageal cancer cells to 5-fluorouracil

Surgery Today

Volumn 31, Issue 9, 2001, Pages 785-790

  Nakamura, Hajime ^a   Sekiguchi, Hiroyuki ^a   Akiyama, Seiji ^a   Hamada, Hirofumi ^b   Fujiwara, Michitaka ^a   Kasai, Yasushi ^a   Ito, Katsuki ^a   Nakao, Akimasa ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

5 Fluorouracil; Adenovirus; Esophageal cancer; Uracil phosphoribosyltransferase

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; URACIL PHOSPHORIBOSYLTRANSFERASE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SENSITIVITY; ENZYME SYNTHESIS; ESCHERICHIA COLI; ESOPHAGUS CANCER; GENE THERAPY; GENETIC RECOMBINATION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN;

ADENOVIRIDAE; ANIMALS; DRUG SYNERGISM; ESCHERICHIA COLI; ESOPHAGEAL NEOPLASMS; FLUOROURACIL; MICE; MICE, NUDE; PENTOSYLTRANSFERASES; SENSITIVITY AND SPECIFICITY; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0034788762     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005950170048     Document Type: Article

References (22)

1. Oesophageal squamous cell carcinoma: A critical review of surgery
2. Esophgaeal carcinoma: Surgery without preoperative adjuvant chemotherapy
3. Three decades of treatment of esophageal squamous carcinoma at the Massachusetts General Hospital
4. Incidence of cancer of the esophagus in the US by histologic type
5. Malignancies of the oesophagus
6. Chemoradiotherapy of esophageal carcinoma
7. Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma
8. Experimental study on chemotherapy using adsorbent charcoal with CDDP administrated directly into the mediastinum following esophagectomy
9. Phase II trial of 5-fluorouracil and low-dose cisplatin in patients with squamous cell carcinoma of the esophagus
10. Transport of nucleic acid precursors
11. Utilization of performed pyrimidine bases and nucleotides
12. Adenovirus-mediated trasduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil
13. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay
14. Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene
15. Regional "pro-drug" gene therapy: Intravenous administration of an adenoviral vector expressing the E. coli cytosine deminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma
16. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
17. Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity
18. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector
19. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulated potent, and long-lasting anti-tumor immunity
20. A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor
21. Induction of antitumor effect on human esophageal carcinoma cells by the retroviral expression of granulocyte macrophage-colony stimulating factor gene
22. Frequent expression of midkine gene in esophageal cancer suggests a potential usage of its promoter for suicide gene therapy