Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor

Journal of Hepatology

Volumn 35, Issue 4, 2001, Pages 490-497

  Wielockx, Ben ^a   Bussolino, Federico ^b   Shapiro, Steven D ^c   Libert, Claude ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF TURIN   (Italy)

^c BARNES JEWISH HOSPITAL   (United States)

Author keywords

Hepatitis; Neutrophils; Serine protease inhibitors; Tumor necrosis factor

Indexed keywords

ALPHA 1 ANTITRYPSIN; GALACTOSAMINE; LEUKOCYTE ELASTASE; SERINE PROTEINASE; THROMBOCYTE ACTIVATING FACTOR; TRYPSIN INHIBITOR; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING TIME; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; GENE TARGETING; HEPATITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INDUCTION; PROTEIN SYNTHESIS;

ACUTE DISEASE; ANIMALS; DRUG COMBINATIONS; GALACTOSAMINE; HEPATITIS, TOXIC; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLATELET ACTIVATING FACTOR; SERINE ENDOPEPTIDASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034788260     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(01)00150-7     Document Type: Article

References (51)

1. Tumor necrosis factor and lymphotoxin
2. Recombinant tumor necrosis factor: Species specificity for a variety of human and murine transformed cell lines
3. In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-gamma, on a syngeneic murine melanoma
4. Endothelial-dependent mechanisms of leukocyte adhesion: Regulation by interleukin-1 and tumor necrosis factor
5. TNF modulation of endothelial and neutrophil adhesion
6. Tumor necrosis factor-α as a myocardial depressant substance
7. Interferon-γ and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells
8. Tumor necrosis factor: Clinical applications
9. Tumor necrosis factor α gene expression and the response to interferon in chronic hepatitis C
10. Expression rate of cytokine mRNA in the liver of chronic hepatitis C: Comparison with chronic hepatitis B
11. Induction of tumor necrosis factor-α production by human hepatocytes in chronic viral hepatitis
12. Apoptosis and viral hepatitis
13. Frequency and distribution of DNA fragmentation as a marker of cell death in chronic liver diseases
14. TNF-α in chronic hepatitis C: The smoking gun?
15. The pathophysiology of tumor necrosis factors
16. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice
17. Galactosamine-induced sensitization to the lethal effects of endotoxin
18. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release
19. The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice
20. α1-acid glycoprotein and α1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice
21. Tumor necrosis factor receptors in patients with chronic hepatitis B virus infection
22. Induction of tumor necrosis factor (TNF) receptor type p55 and p75 in patients with chronic hepatitis C virus (HCV) infection
23. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis
24. α 1-antitrypsin inhibits the lethal response to TNF in mice
25. Augmentation of tumor metastasis by platelet-activating factor
26. Human serum acid-labile factor is an acylhydrolase that inactivates platelet-activating factor
27. Production of platelet-activating factor by chick retina
28. Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor
29. Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1α
30. An ELISA for detection of apoptosis
31. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G
32. Characterization of tumor necrosis factor-deficient mice
33. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
34. Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism
35. Contribution of complement-stimulated hepatic macrophages and neutrophils to endotoxin-induced liver injury in rats
36. Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality
37. Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor
38. Synthesis and release of platelet-activating factor is inhibited by plasma α1-proteinase inhibitor or α1-antichymotrypsin and is stimulated by proteinases
39. Involvement of a serine protease in the synthesis of platelet-activating factor by endothelial cells stimulated by tumor necrosis factor-α or interleukin-1α
40. Inhibition of porcine elastase by turkey ovomucoid and chicken ovoinhibitor
41. Reduction and reoxidation of turkey ovomucoid: A protein with dual and independent inhibitory activity against trypsin and α-chymotrypsin
42. Inhibitory effects of crude soybean trypsin inhibitor on pancreatic ductal carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine
43. Bowman-Birk inhibitor concentrate reduces colon inflammation in mice with dextran sulfate sodium-induced ulcerative colitis
44. Tumor necrosis factor-induced lethal hepatitis: Pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH
45. Leukocyte alterations do not account for hepatitis induced by endotoxin or TNF alpha in galactosamine-sensitized mice
46. The role of complement activation in tumour necrosis factor-induced lethal hepatitis
47. Hepatocyte injury by activated neutrophits in vitro is mediated by proteases
48. The mechanism of hepatic cellular injury in sepsis: An in vitro study of the implications of cytokines and neutrophils in its pathogenesis
49. Activation of the first component of complement, C1: Comparison of the effect of sixteen different enzymes on serum C1
50. Tissue destruction by neutrophils
51. Shock and tissue injury induced by recombinant human cachectin