Transdifferentiation in neoplastic development and its pathological implication

Histology and Histopathology

Volumn 16, Issue 4, 2001, Pages 1249-1262

  Zhang, Z ^a   Yuan, X M ^a   Li, L H ^a   Xie, F P ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Genetic instability; Histogenesis; Neoplastic cells; Transdifferentiation

Indexed keywords

GROWTH FACTOR;

CANCER CELL; CANCER RESEARCH; CARCINOGENESIS; CELL DIFFERENTIATION; EMBRYO DEVELOPMENT; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC STABILITY; HISTOGENESIS; HISTOPATHOLOGY; HUMAN; MALIGNANT TRANSFORMATION; MESENCHYME CELL; NEUROECTODERM; NEUROENDOCRINE DISEASE; PHENOTYPE; REVIEW; STEM CELL; TUMOR CELL;

ANIMALS; CELL DIFFERENTIATION; EPITHELIAL CELLS; HUMANS; MESODERM; NEOPLASMS; NEUROSECRETORY SYSTEMS;

EID: 0034782222     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (122)

1. Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed mullerian tumours
2. Genetic characterization of the multipotent dedifferentiated state of pigmented epithelial cells in vitro
3. Epithelial-mesenchymal transdifferentiation and extracellular matrix gene expression in pleomorphic adenomas of the parotid salivary gland
4. Relation of neuroglial marker expression and EWS gene fusion types in MIC2/CD99-positive tumors of the Ewing family
5. The origin of gut and pancreatic neuroendocrine (APUD) cell - The last word?
6. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma
7. Sarcomatoid carcinomas of the kidney
8. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
9. A histiocyte-specific marker in the diagnosis of malignant fibrous histiocytoma. Use of monoclonal antibody KP-1 (CD68)
10. Cadherin expression in carcinoma: Role in the formation of cell junction and the prevention of invasiveness
11. Intriguing cases. Case 6
12. Reactive and neoplastic serosal tissue. A light-microscopic, ultrastructural, and immunocytochemical study
13. Reversible transition towards a fibroplastic phenotype in a rat carcinoma cell line
14. Transdifferentiation of prostate cancer cells to a neuroendocrine cell phenotype in vitro and in vivo
15. Is synovial sarcoma a carcinosarcoma of connective tissue?
16. Sarcomatoid variant of anaplastic large-cell Ki-1 lymphoma
17. Correlation of transformation from epithelial to mesenchymal-like morphology and endogenous bFGF levels in human nasopharyngeal carcinoma cells
18. Pulmonary blastoma with malignant melanoma component
19. The endodermal origin of the endocrine cells of an adenocarcinoma of the colon of the rat
20. Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells
21. Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: Correlation with histopathological parameters, hormone receptors, and oncoproteins
22. Extracellular matrix components induce endocrine differentiation in vitro in NCL-H716 cells
23. Primitive neuroectodermal tumor and Ewing's sarcoma
24. Cytogenetics of tumors of soft tissue and bone
25. Differentiation of lens tissue from the progeny of chick retinal pigment cells cultured in vitro: A demonstration of a switch of cell type in clonal cell culture
26. Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
27. Malignant fibrous histiocytoma. A clinicopathologic study of 130 cases
28. Medial edge epithelium transforms to mesenchyme after embryonic palatal shelves fuse
29. Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the chromosomes and morphology (CHAMP) collaborative study group
30. Correlation between clinicopathological features and karyotype in spindle cells sarcomas. A report of 130 cases from the CHAMP study group
31. Ela induces the expression of epithelial characteristics
32. Vasoactive intestinal peptide (VIP) and VIP receptors: Gene expression and growth modulation in medulloblastoma and other central primitive neuroectodermal tumors of childhood
33. Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity
34. Carcinosarcoma of the uterus with extensive neuroectodermal differentiation
35. Origin and relationship between different cell types in malignant fibrous histiocytoma
36. Multidirectional differentiation in a newly established human epitheloid sarcoma cell line GRU1 with coexpression of vimentin cyto-keratin and neurofilament proteins
37. Experimentally produced synovial sarcomas
38. Histogenesis and differentiation. A re-evaluation of these concepts as criteria for the classification of tumors
39. Coexpression patterns of vimentin and glial filament protein with cytokeratins in the normal, hyperplastic and neoplastic breast
40. Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and cutaneous melanoma: Exploring the histogenetic relationship between these two clinicopathological entities
41. Epithelial-mesenchymal transformation during palatal fusion: Carboxyfluorescein traces cells at light and electron microscopic levels
42. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
43. Differences in genetic alterations between primary lobular ductal breast cancers detected by comparative genomic hybridization
44. Amphiricine carcinoma of the uterine cervix
45. Soft tissue sarcoma with additional anaplastic components. A clinicopathologic and immunohistochemical study of 27 cases
46. Retrodifferentiation and cell death
47. Extracellular matrix alters epithelial differentiation
48. Distribution of extracellular matrix components in adamantinoma of long bones suggests fibrous-to-epithelial transformation
49. Retroperitoneal liposarcoma with combined well-differentiated and myxoid malignant fibrous histiocytoma-like myxoid areas
50. Malignant fibrous histiocytoma. An ultrastructural study of eleven cases
51. Transdifferentiation of murine squamous vaginal epithelium in proestrus is associated with changes in the expression of keratin polypeptides
52. Malignant fibrous histiocytoma. A tumor of facultative histiocytes showing mesenchymal differentiation in cultured cell lines
53. The E-cadherin/epidermal growth factor receptor interaction. A hypothesis of reciprocal and reversible control of intercellular adhesion and cell proliferation
54. Experimental tumors with features of malignant fibrous histiocytomas. Light microscopic and electron microscopic investigations on tumors produced by cell transplantation of an established fibrosarcoma cell line
55. An intra-abdominal small round cell neoplasm with features of primitive neuroectodermal and desmoplastic round cell tumor and a EWS/FLI1 fusion transcript
56. SYT-SSX gene fusion as a determinant of morphology and prognosis in sarcoma
57. Clonal origin of columnar, mucous, and endocrine cell lineages in human colorectal epithelium
58. Spontaneous losses of control of cytokeratin gene expression in transformed, non-epithelial human cells occurring at different levels of regulation
59. Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: Comparative molecular analysis of epithelial and mesenchymal components
60. Differentiation of fibroblast-like cells into macrophages
61. The emerging molecular genetics of sarcoma translocations
62. The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma. Evidence of distinct molecular genetic pathways
63. An immunohistochemical study of differentiation in malignant fibrous histiocytoma
64. Genetic instabilities in humans
65. Rings, dicentrics, and telomeric association in histiocytomas
66. Characteristic karyotypic anomalies identify subtypes of malignant fibrous hitiocytoma
67. Inactivation of retinoblastoma family proteins by SV40 T antigen results in creation of a hepatocyte growth factor/scatter factor autocrine loop associated with an epithelial-fibroblastoid conversion and invasiveness
68. Ewing's sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI-1 for transformation
69. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
70. Pulmonary small cell carcinoma showing tripartite differentiation in individual cells
71. Carcinosarcoma arising in eccrine spiradenoma (a clinicopathologic and immunohistochemical study of 2 cases)
72. The molecular pathology of small round-cell tumors - Relevance to diagnosis, prognosis, and classification
73. "Differentiation" in bone and soft-tissue tumors. A histological indicator of tumor progression
74. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
75. Expression of neural cell adhesion molecules and neurofilament protein isoforms in Ewing's sarcoma of bone and soft tissue sarcomas other than rhabdomyosarcoma
76. Sarcomatoid carcinoma of the lung. A clinicopathologic study of 37 cases
77. Gliosarcoma of the posterior fosa with features of a malignant fibrous histiocytoma
78. Breast carcinoma diverging to aberrant melanocytic differentiation. A case report with histopathologic and loss of heterozygosity analyses
79. Translocation X18 in a biphasic synovial sarcoma with morphologic feature of neural differentiation
80. Desmoplastic small round cell tumor II. An ultrastructural and immunohistoshemical study with emphasis on new immunohistochemical markers
81. Supernumerary ring chromosomes in five bone and soft tissue tumors of low or borderline malignancy
82. Cytogenetic intratumor heterogeneity in soft tissue tumors
83. Metamorphosed fibroblasts and their relatiion to the histogenesis of malignant fibrous histiocytoma in experimental murine model
84. Loss of heterozygosity in p53, BRCA1, and estrogen receptor genes and correlation to expression of p53 protein in ovarian epithelial tumors of different cell types and biological behavior
85. Primary combined malignant melanoma and ductal carcinoma of the breast. A report of two cases
86. Vimentin filaments follow the pre-existing cytokeratin network during epithelial mesenchymal transition of cultered neonatal rat hepatocytes
87. TFG-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NmuMG breast epithelial cells
88. Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells
89. Distinct mdm2/p53 expression patterns in liposarcoma subgroups implications for different pathogenetic mechanisms
90. Carcinosarcoma arising in a duct papilloma
91. Pleomorphic (giant and spindle cell) carcinoma by K-ras-2 and p53 analysis
92. Sarcomatoid renal cell carcinoma: A clinicopathologic study of 42 cases
93. Sarcomatoid carcinoma of the lung: Immunohistochemical and ultrastructural studies of 14 cases
94. A study of analyze the origin of tumor cells in malignant fibrous histiocytomas. A multiparametric characterization
95. Characterization of tumor cells in malignant fibrous histiocytomas and other soft tissue tumors, in comparison with malignant histiocytes. II. Immunoperoxidase study on cryostat sections
96. Combined morphologic and karyotypic study of 59 atypical lipomatous tumors. Evaluation of their relationship and differential diagnosis with other adipose tissue tumors (A report of the CHAMP study group)
97. Malignant fibrous histiocytoma induced by intra-articular injection of 9,10-dimethyl-1, 2-benzanthracene in the rat. Pathological and enzyme histochemical studies
98. Expression of E-cadherin in bone and soft tissue sarcomas: A possible role in epithelial differentiation
99. Malignant fibrous histiocytoma (MFH). A comparison of MFH in man and animals. A critical review
100. Mesenchymal-epithelial conversions induced by 5-azacytidine: Appearance of cytokeratin endo-A messenger RNA
101. Sarcomatoid carcinoma of the prostate. A clinicopathologic study of 12 patients
102. Establishment and characterization of neoplastic cells from a malignant fibrous histiocytoma. A possible stem cell line
103. Variability of histologic pattern in recurrent soft tissue sarcomas originally diagnosed as liposarcoma
104. Further characterization of the human clear cell sarcoma line HS-MM demonstrating a specific T(12;22) (q13;q12) translocation and hybrid EWS/ATF-1 transcript
105. Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI-1 fusion gene
106. Carcinosarcomas of the female genital tract. A pathologic study of 29 metastatic tumors: Further evidence for the dominant role of the epithelial component and the conversion theory of histogenesis
107. Malignant fibrous histiocytoma. Expression of monocyte/macrophage differentiation antigens detected with monoclonal antibodies
108. EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts
109. Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis
110. Is the EWS/FLI-I fusion transcipt specific for Ewing's sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor types
111. Hepatocarcinomas, cholangiocarcinomas, and hepatoblastomas produced by chemically transformed cultured rat liver epithelial cells
112. The Met proto-oncogene mesenchymal to epithelial cell conversion
113. Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line
114. Induction of cytokeratin expression in human mesenchymal cells
115. Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors
116. Cell transdetermination
117. Vimentin metaplasia in renal cortical tubules of preneoplastic, neoplastic, aging and regenerative lesions of rats and humans
118. Metaplastic carcinoma of the breast III carcinosarcoma
119. Correlation of histologic subtypes and replication error phenotype with comparative genomic hybridization in gastric cancer
120. Primary malignant melanoma (clear cell sarcoma) of bone: Report of a case arising in the Ulna
121. Experimental approach to fibrous histiocytoma
122. Transdifferentiation of neoplastic cell