Interferon-alpha 2b modulation of doxorubicin sensitivity in a multidrug resistant cell line

Journal of Experimental and Clinical Cancer Research

Volumn 20, Issue 3, 2001, Pages 393-400

  Gritti, M F L ^a   Beviacqua, M ^a   Bordenave, R H ^a   Rumi, L S ^a  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

Author keywords

Apoptosis; Bcl 2; HLA ABC; Interferon alpha 2b; P 170

Indexed keywords

ALPHA2B INTERFERON; DOXORUBICIN; GLYCOPROTEIN P; HLA ANTIGEN; PROTEIN BCL 2; TETRAZOLIUM; THYMIDINE; TRITIUM;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL SURVIVAL; COLONIC NEOPLASMS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG SYNERGISM; G2 PHASE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HLA-A ANTIGENS; HLA-C ANTIGENS; HUMANS; INTERFERON ALFA-2B; MEMBRANE PROTEINS; MITOSIS; ONCOGENE PROTEIN V-CBL; P-GLYCOPROTEIN; RETROVIRIDAE PROTEINS, ONCOGENIC; TUMOR CELLS, CULTURED;

EID: 0034779860     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Clinical multidrug resistance in cancer: A multifactorial problem
2. On the origins of clinical drug resistance
3. P-glycoprotein - A mediator of multidrug resistance in tumour cells
4. Bcl-2 initiates a new category of oncogenes: Regulators of cell death
5. Apoptosis and chemotherapy resistance
6. Bcl-2: Prevention of apoptosis as a mechanism of drug resistance
7. Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers
8. New insights into the mechanisms of interferon: Alfa: An immunoregulatory and anti-inflammatory cytokine
9. The neglected role of type I interferon in the T-cell response: Implications for its clinical use
10. N,N-dimetylformamide-induced alteration of cell culture characteristics and loss of tumorigenicity in cultured human colon adenocarcinoma cells
11. Regulation of cytokine expression by interferon-a in human bone marrow stromal cells: Inhibition of hematopoietic growth factors and induction of interleukin-1 receptor antagonist
12. Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing
13. Monoclonal antibody to an external epitope of the human mdr-1 P-glycoprotein
14. How to probe clinical tumor samples for P-glycoprotein and multidrug resistance-associated protein
15. Differential regulation of p53, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells
16. Interferon potentiates cytotoxic effects of 5-fluorouracil on cell proliferation of established human cell lines originating from neoplastic tissues
17. Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells
18. Interferons modify in vitro proliferation of human bladder transitional cell carcinoma in the presence of doxorubicin and mitomycin C
19. Enhacement of sensitivity of lung adenocarcinoma cells to growth-inhibitory activity of interferon a by differenciation-inducing agents
20. Synergistic antitumor effects of a combination of interferon and tamoxifen on estrogen receptor-positive and receptor-negative human tumor cell lines in vivo and in vitro
21. Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: A review
22. Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression
23. Correlations between natural resistance to doxorubicin, proliferative activity and expression of P-glycoprotein 170 in human kidney tumor cell lines
24. Enhacement by recombinant human interferon alfa of the reversal of multidrug resistance by MRK-16 monoclonal antibody
25. Etude de la modulation par l'interferon alpha et/ou l'ácide tout transretinoique de la cytotoxicité de l'adriamycine sur le cellules K 562 et K 562 adri
26. Reversal of adriamycin resistance by recombinant a-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells
27. Disminución de la expresión de la glicoproteína P-170 por el tratamiento combinado interferón-α2b/ vincristina sobre una línea celular resistente a multidroga. Nuevas Tendencias en Oncologia
28. Effect of alpha-interferon on P-glycoprotein expression and function and on verapamil modulation of doxorubicin resistance
29. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53
30. Increased apoptosis accompanies neoplastic development in the human colorectum
31. Bcl- 2 but not p53 expression is associated with resistance to chemotherapy in advanced breast cancer
32. Apoptosis in cancer therapy: Crossing the threshold
33. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO/Fas) receptor/ligand system and involves activation of wild-type p53
34. Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract
35. Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
36. Taxol and estramusine-induced modulation of human prostate cancer cells apoptosis via alteration in bcl-xl and bak expresion
37. The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2 and involves 1CE-like proteases