Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression

Clinical Cancer Research

Volumn 2, Issue 8, 1996, Pages 1427-1433

  Seliger, Barbara ^a   Höhne, Alexandra ^a   Knuth, Alexander ^b   Bernhard, Helga ^a   Ehring, Bettina ^c,d   Tampé, Robert ^c,d   Huber, Christoph ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b KRANKENHAUS NORDWEST   (Germany)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ARTICLE; CELL DENSITY; CELL MEMBRANE PERMEABILITY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; KIDNEY CARCINOMA; MAJOR HISTOCOMPATIBILITY COMPLEX; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TRANSPORT;

ATP-BINDING CASSETTE TRANSPORTERS; CARCINOMA, RENAL CELL; CYSTEINE ENDOPEPTIDASES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KIDNEY NEOPLASMS; MULTIENZYME COMPLEXES; PROTEINS; RNA, MESSENGER; TEMPERATURE; TUMOR CELLS, CULTURED;

EID: 0029758409     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Zinkernagel, R. M., and Doherty, P. C. MHC restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity, function and responsiveness. Adv. Immunol., 27: 51-177, 1979.
2. Rötzschke, O., Falk, K., Deres, K., Schild, H., Norda, M., Metzger, J., Jung, G., and Rammensee, H. G. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature (Lond.), 348: 252-254, 1990.
3. Townsend, A., and Bodmer, H. Antigen recognition by class I-restricted T lymphocytes. Annu. Rev. Immunol., 7: 601-624, 1989.
4. Yewdell, J. W., and Bennink, J. R. Cell biology of antigen processing and presentation to MHC class I molecule-restricted T lymphocytes. Annu. Rev. Immunol., 52: 1-123, 1992.
5. Brown, M. C., Driscoll, J., and Monaco, J. J. Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes. Nature (Lond), 353: 355-357, 1991.
6. Glynne, R., Powis, S. H., Beck, S., Kelly, A., Kerr, L. A., and Trowsdale, J. A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC. Nature (Lond.), 353: 357-360, 1991.
7. Goldberg, A. L., and Rock, K. L. Proteolysis, proteasomes and antigen presentation. Nature (Lond.), 357: 375-378, 1992.
8. Ortiz-Navarette, V., Seelig, A., Gernold, M., Frentzel, S., Kloetzel, J. M., and Hämmerlmg, G. J. Subunit of the "20S" proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex. Nature (Lond.), 353: 663-665, 1992.
9. Arnold, D., Driscoll, J., Androlewicz, M., Hughes, E., Cresswell, P., and Spies, T. Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules. Nature (Lond.), 360: 171-174, 1992.
10. Momburg, F., Ortiz-Navarette, V., Neefjes, J., Goulmy, E., van de Wal, Y., Spits, H., Powis, S. J., Butcher, G. W., Howard, J. C., Walden, P., and Hämmerling, G. J Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation. Nature (Lond.), 360: 174-177, 1992.
11. Cox, J. H., Yewdell, I. W , Eisenlohr, L. C , Johnson, P. R., and Bennink, J. R. Antigen presentation requires transport of MHC class I molecules from the endoplasmatic reticulum. Science (Washington DC), 247: 715-718, 1990.
12. Deverson, E., Gow, V., Coadwell, W. I., Monaco, J. J., Butcher, G. W., and Howard, J C. MHC class II region encoding proteins are related to the multidrug resistance family of transmembrane transporters. Nature (Lond.), 348: 738-741, 1990.
13. Monaco, J. J., Cho, S., and Attaya, M. Transport protein genes in the murine MHC: possible implications for antigen processing. Nature (Lond.), 250: 1723-1726, 1990.
14. Trowsdale, J., Hanson, I., Mockridge. L, Beck, S., Townsend, A., and Kelly, A. Sequence encoded in the class II region of the MHC related to the "ABC" superfamily of transporters. Nature (Lond.), 348: 741-744, 1990.
15. Meyer, T. H., van Endert. P. M., Uebel, S., Ehring, B., and Tampé, R. Functional expression and purification of the transporter associated with antigen processing in insect cells. FEBS Lett., 351: 443-447, 1994.
16. Neefjes, J. J., Momburg, F., and Hämmerling, G. J. Selective and ATP-dependent translocation of peptides by MHC-encoded transporter. Science (Washington DC), 261: 769-771, 1993.
17. Schumacher, T. N. M., Bruijn, M. L. H., Vernie, L. N., Kast, W. M., Melief, C. J M., Neefjes, J. J., and Ploegh, H. L. Peptide selection of MHC class I molecules. Nature (Lond.), 350: 703-709, 1991.
18. Schumacher, T. N. M., Kantesaria, D. V., Heemels, M. T., Ashton-Rickardt, P. G., Shepherd, J. C., Früh, K., Young, Y., Peterson, P. A., Tonegawa, S., and Ploegh, H. L. Peptide length and sequence specificity of mouse TAP1/TAP2 translocator. J. Exp. Med., 179: 533-540, 1994.
19. van Endert, P. M., Tampé, R., Meyer, T. H., Tisch, R., Bach, J. F., and McDevitt, H. O. A sequential model of peptide binding and transport by the transporters associated with antigen processing. Immunity, 1: 491-500, 1994.
20. Mausdley, D. J., and Pound. J. D. Modulation of MHC antigen expression by viruses and oncogenes. Immunol. Today, 12: 429-431, 1991.
21. Tanaka, K., Yoshioka, T., Bieberich, C., and Jay, G. Role of major histocompatibility complex class I antigens in tumor growth and metastasis. Annu. Rev. Immunol., 6: 359-380, 1988
22. Gamdo, F., Cabrera, T., Concha, A., Glew, S., Ruiz-Cabello, F., and Stern, P. L. Natural history of HLA expression during tumor development. Immunol. Today, 14: 491-499, 1993.
23. Festenstein, K. B., and Garrido, F. MHC antigens and malignancy. Nature (Lond.), 322: 502-503, 1986.
24. 2-m gene expression. J. Clin. Invest., 87: 284-292, 1991.
25. Doyle, A., Martin, W. J., Funa, K., Gazdar, A., Carney, D., Martin, S. E., Linnoila, I., Cuttitta, F., Mulshine, J , Bunn, P., and Minna, J. Markedly decreased expression of class I histocompatibility antigens, proteins, and mRNA in human small cell lung cancer. J. Exp. Med., 161: 1135-1151, 1985.
26. Blanchet, O., Bourge, J. F., Zinser, H., Tatari, Z., Degos, L., and Paul, P. DNA binding of regulatory factors interacting with MHC class I gene enhancer correlates with MHC class I transcriptional level in a MHC class I defective cell line. Int. J. Cancer, 6: 138-145, 1991.
27. Lassam, N., and Jay, G. Suppression of MHC class I RNA in highly oncogenic cells occurs at the level of transcription initiation. J. Immunol., 143: 3792-3797, 1989.
28. Paabo, S., Sverinsson, L., Anderson, M., Martens, I., Nilsson, T., and Pettersson, P. A. Adenovirus proteins and MHC expression. Adv. Cancer Res., 52: 151-163, 1989.
29. Seliger, B., and Pfizenmaier, K. Post-transcriptional downregulation of MHC class I expression in oncogene-transformed cells is reverted by IFN-α and IFN-γ. J. Immunogenet., 16, 315-320, 1989.
30. Versteeg, R., Noordermeer, I. A., Kruse-Wolters, M., Ruiter, D. J., and Schrier, P. I. c-myc downregulates class I HLA expression in human melanomas. EMBO J., 7: 1023-1029, 1988.
31. Ribcrdy, J. M., and Cresswell, P. The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation J. Immunol., 148: 2586-2590, 1992.
32. -8+ T cells. Cell, 71: 1205-1214, 1992.
33. Cerundolo, V. J., Alexander, J., Anderson, K., Lamb, C., Cresswell, P., McMichael, A., Gotchi, F., and Townsend, A. Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature (Lond.), 34: 449-452, 1990
34. Attaya, M., Jameson, S., Martinez, C. K., Hermel, E., Aldnch, C., Forman, J., Fischer-Lindahl, K., Bevan, M., and Monaco, J. J. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature (Lond.), 355: 647-649, 1992.
35. Cromme, F. V., Airey, J., Heemels, M. T., Ploegh, H. L., Keating, P. J., Stern, P. L., Meijer, J. C. L. M., and Walboomers, C. M. M. Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. J. Exp. Med., 179: 335-340, 1994.
36. Restifo, N. P., Esquivel, F , Kawakami, Y., Yewdell, J. W., Mule, J. J., Rosenberg, S. A., and Bennink, J. R. Identification of human cancers deficient in antigen processing. J. Exp. Med., 177: 265-272, 1993.
37. Kaklamanis, L., Townsend, A., Doussis-Anagnostopoulon, I. A., Mortensen, N., Harris, A. L., and Gatter, K. C. Loss of major histocompatibility complex-encoded transporter-associated with antigen presentation (TAP) in colorectal cancer. Am. J. Pathol., 145: 505-509, 1994.
38. Rotem-Yeduhar, R., Winograd, S., Sela, S., Coligan, J. E., and Ehrlich, R. Downregulation of peptide transporter genes in cell lines transformed with highly oncogenic adenovirus 12. J. Exp. Med., 180: 477-488, 1994.
39. Epperson, D. E., Arnold, D., Spiess, T., Cresswell, P., Pober, J. S., and Johnson, D. R. Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells. J. Immunol., 149: 3297-3301, 1992.
40. Buszello, H., and Ackermann, R. Expression of HLA class I antigens on renal cell carcinoma and non-transformed renal tissue. Eur. Urol., 21: 70-74, 1992.
41. Cordon-Cardo, C., Fuks, Z., Drobnjak, M., Moreno, C., Eisenbach, L., and Feldmann, M. Expression of HLA-A, B, C antigens in primary and metastatic tumor cell populations of human carcinomas. Cancer Res., 54: 6372-6380, 1991.
42. Aulitzky, W. E., Grosse-Wilde, H., Westhoff, U., Tilg, H., Aulitzky, W., Gastl, G., Herold, M., and Huber, C. Enhancement of serum levels of soluble HLA class I molecules are induced by treatment with recombinant interferon-γ. Clin. Exp. Immunol., 86: 236-239, 1991.
43. Mattijssen, V., van Morselaar, J., DeMulder, P. H., Schalkwijk, L., and Ruiter, D. J. Human leukocyte antigen expression in renal cell carcinoma lesions does not predict the response to Interferon therapy. J. Immunother., 12: 64-69, 1992.
44. Bernhard, H., Karbach, J., Wolfel, T., Busch, P., Störkel, S., Stöckle, M., Wölfel, C., Seliger, B., Huber, C., Meyer zum Büschenfelde, K. H., and Knuth, A. Cellular immune response to human renal cell carcinomas: definition of a common antigen recognized by HLA-A2 restricted cytotoxic T lymphocyte (CTL) clones. Int. J. Cancer, 59: 837-842, 1994.
45. Ljunggren, H. G., and Kärre, K. Host resistance directed selectively against H-2 deficient lymphorna variants. J. Exp. Med., 162: 1745-1759, 1985.
46. Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., and Rutter, W. J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18: 5294-5299, 1979.
47. Spies, T., Bresnahan, M , Bahram, S., Arnold, D., Blanck, G., Mellins, E., Pious, D., and DeMars, R. A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. Nature (Lond.), 348: 744-747, 1990.
48. Feinberg, A. P., and Vogelstein, B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 132: 6-13, 1984.
49. Brodsky, F. M., Parham, P., Barn. J. C., Crumpton, M. J., and Bodmer, W. F. Monoclonal antibodies for analysis of the HLA system. Immunol. Rev., 47: 342-367, 1979.
50. Wölfel, T., van der Pel, A., Brichard, V., Schneider, J., Seliger, B., Meyer zum Büschenfelde, K. H., and Boon, T. Two tyrosinase non-apeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes. Eur. J. Immunol, 24: 759-764, 1994.
51. Goodenow, R. S., Vogel, J. M., and Linsk, R. L. Histocompatibility antigens on murine tumors. Science (Washington DC), 230: 777-783, 1985.
52. Schreiber, H., Ward, P. L., Rowley, D. A., and Strauss, H. J. Unique tumor specific antigens. Annu. Rev. Immunol., 6: 465-472, 1988.
53. Shemesh, J., Rotem-Yeduhar, R., and Ehrlich, R. Transcriptional and posttranscriptional regulation of class I major histocompatibility complex genes following infection and transformation with human adenoviruses. J. Virol, 65: 5544-5548, 1991
54. Townsend, A , Ohlen, C., Bastin, J., Ljunggren, H G., Foster, L., and Kärre, K. Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature (Lond.), 340: 443-448, 1989.
55. 2-microglobulin in the cellular transport and cell surface expression of murine class I histocompatibility molecules. J. Immunol., 142: 2796-2806, 1989.
56. -CD8+ cytolytic T cells. Nature (Lond.), 344, 742-745, 1990.
57. Wright, K. L , White, L. C., Kelly, A., Beck, S., Trowsdale, J., and Ting, J. Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. J. Exp. Med., 181: 1459-1471, 1995.
58. Rivolitim, L., Barracchini, K. C , Viggiano, V., Kawakami, Y., Smith, A., Mixon, A., Restifo, N. P., Topalian, S., Simonis, T B., Rosenberg, S. A., and Manncola, F. M. Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T-lymphocytes. Cancer Res., 55: 3149-3157, 1995.
59. Salcedo, M., Momburg, F., Hammerling, G. J., and Ljunggren, H. G. Resistance to natural killer cell lysis conferred by TAP1/TAP2 genes in human antigen-processing mutant cells. J. Immunol., 152: 1702-1708, 1995.