Fasciola: Kinetics and quality of humoral responses to fatty acid binding protein and cathepsin L following delivery as DNA vaccines in mice

Experimental Parasitology

Volumn 97, Issue 3, 2001, Pages 154-160

  Smooker, Peter M ^a   Kennedy, Nicholas J ^a   Steeper, Kelly R ^a   Christopoulos, Helen ^a   Spithill, Terry W ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN L; DNA VACCINE; FATTY ACID BINDING PROTEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; PARASITE ANTIGEN; SECRETORY PROTEIN; SIGNAL PEPTIDE;

ADOLESCENT; ANIMAL CELL; ANTIBODY TITER; ARTICLE; CELL STRAIN COS1; FASCIOLA GIGANTICA; FASCIOLA HEPATICA; FEMALE; HUMORAL IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; VACCINATION;

EID: 0034776098     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.2001.4601     Document Type: Article

References (43)

1. Fasciola hepatica: Parasite-secreted proteinases degrade all human IgG subclasses: Determination of the specific cleavage sites and identification of the immunoglobulin fragments produced
2. Influence of cellular location of expressed antigen on the efficacy of DNA vaccination: Cytotoxic T lymphocyte and antibody responses are suboptimal when antigen is cytoplasmic after intramuscular DNA immunization
3. Identification of 3-hydroxyproline residues in several proteins of Fasciola hepatica
4. Thiol proteases released in vitro by Fasciola hepatica
5. Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin
6. DNA vaccines
7. Fasciola hepatica cathepsin L proteinase cleaves fibrinogen and produces a novel type of fibrin clot
8. Isolation of a cDNA encoding Fasciola hepatica cathepsin L2 and functional expression in Saccharomyces cerevisiae
9. Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection
10. Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle
11. DNA vaccines: Immunology, application, and optimization
12. Immune responses in Indonesian thin tail and Merino sheep during a primary infection with Fasciola gigantica: Lack of a specific IgG2 antibody response is associated with increased resistance to infection in Indonesian sheep
13. An improved plasmid DNA expression vector for direct injection into skeletal muscle
14. Acquired resistance to Faciola hepatica in cattle using a purified adult worm antigen
15. Acquired immunity in schistosomiasis with purified Fasciola hepatica cross-reactive antigens
16. Recombinant vaccinia viruses and gene gun vectors expressing the large subunit of Schistosoma mansoni calpain used in a murine immunization-challenge model
17. Collagenase activity of immature Fasciola hepatica
18. Plasmid DNA expressing a secreted or a nonsecreted form of hepatitis C virus nucleocapsid: Comparative studies of antibody and T-helper responses following genetic immunization
19. DNA vaccines for parasitic infections
20. Successful DNA immunisation of rats against fasciolosis
21. DNA vaccines
22. Vaccine developments
23. An OspA-based DNA vaccine protects mice against infection with Borrelia burgdorferi
24. The proteases and pathogenicity of parasitic protozoa
25. Correlation of specific antibody titer and avidity with protection in cattle immunized against Fasciola hepatica
26. Fasciola hepatica infection downregulates Thl responses in mice
27. Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep
28. IgE production in rat fascioliasis
29. Genetic vaccination strategies for enhanced cellular, humoral and mucosal immunity
30. Fasciola hepatica: Molecular cloning, nucleotide sequence and expression of a gene encoding a polypeptide homologous to a Schistosoma mansoni fatty acid binding protein
31. Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica
32. Isolation, cloning, and expression of fatty-acid binding proteins from Fasciola gigantica
33. Humoral responses in mice following vaccination with DNA encoding glutathione S-transferase of Fasciola hepatica: Effects of mode of vaccination and the cellular compartment of antigen expression
34. A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica
35. A Schistosoma mansoni fatty acid-binding protein, Sm 14, is the potential basis of a dual-purpose anti-helminth vaccine
36. Morphological and biochemical studies on absorption and secretion in the alimentary tract of Fasciola hepatica
37. Structural and functional studies on different human FABP types
38. DNA-based vaccination using Schistosoma japonicum (Asian blood-fluke) genes
39. Vaccination of sheep with purified cysteine proteinases of Fasciola hepatica decreases worm fecundity
40. Fasciola hepatica: Characterization and cloning of the major cathepsin B protease secreted by newly excysted juvenile liver fluke
41. Direct gene transfer into mouse muscle in vivo
42. Cloning and sequence analysis of the major cysteine protease expressed in the trematode parasite Fasciola spp