Fasciola hepatica infection downregulates Th1 responses in mice

Parasite Immunology

Volumn 22, Issue 3, 2000, Pages 147-155

  O'Neill, Sandra M ^a,b   Brady, Miriam T ^b   Callanan, John J ^c   Mulcahy, Grace ^c   Joyce, Patrick ^c   Mills, Kingston H G ^b   Dalton, John P ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Cytokines; Fasciola hepatica; Helminth; Immune responses; Th cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FASCIOLA HEPATICA; FASCIOLIASIS; FEMALE; LYMPH NODE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL; SPLEEN CELL; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODIES, HELMINTH; CYTOKINES; DOWN-REGULATION; FASCIOLA HEPATICA; FASCIOLIASIS; FEMALE; IMMUNOGLOBULIN G; LYMPH NODES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SPLEEN; TH1 CELLS; TH2 CELLS;

ANIMALIA; DIGENEA (FLUKES); FASCIOLA HEPATICA; HEPATICA; MURINAE; TREMATODA; VERMES;

EID: 0034011527     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.2000.00290.x     Document Type: Article

References (34)

1. Baeza E., Poitou I. & Boulard C. (1994b) Influence of pro-inflammatory treatments on experimental infection of rats with Fasciola hepatica: changes in serum levels of inflammatory markers during the early stages of fasciolosis. Research in Veterinary Science 57, 219-230
2. Baeza E., Poitou I., Delers F. & Boulard C. (1994a) Influence of anti-inflammatory treatments on experimental infection of rats with Fasciola hepatica: changes in serum levels of inflammatory markers during the early stages of fasciolosis. Research in Veterinary Science 57, 172-179
3. Bozas S.E., Panaccio M., Creaney J. et al. (1995) Characterization of a novel Kunitz-type molecule from the trematode Fasciola hepatica. Molecular and Biochemical Parasitology 74, 19-24
4. Brown W.C., Woods V.M., Chitko-McKown C.G., Hash S.M. & Rice-Ficht A.C. (1994) CD4+ T-cell clones obtained from cattle chronically infected with Fasciola hepatica and specific for adult worm antigen express both unrestricted and Th2 cytokine profiles. Infection and Immunity 62, 818-827
5. Caulada-Benedetti Z., Al-Zamel F., Sher A. & James S. (1991) Comparison of Th1-and Th2-associated immune reactivities stimulated by single versus multiple vaccination of mice with irradiated Schistosoma mansoni cercariae. Journal of Immunology 146, 1655-1660
6. Cervi L., Rubinstein H. & Masih D.T. (1996) Involvement of excretion-secretion products from Fasciola hepatica in inducing suppression of the cellular immune responses. Veterinary Parasitology 61, 97-111
7. Chauvin A., Bouvet C. & Boulard C. (1995) Humoral and cellular immune response to Fasciola hepatica experimental primary and secondary infection in sheep. International Journal for Parasitology 25, 1227-1241
8. Cheever A.W., Williams M.E., Wynn T.A. et al. (1994) Anti-IL4 treatment of Schistosoma mansoni-infected mice inhibits development of T-cells and non-B, non-T cells expressing Th2 cytokines while decreasing eg-induced hepatic fibrosis. Journal of Immunology 153, 753-759
9. Clery D.G. & Mulcahy G. (1998) Lymphocyte and cytokine responses of young cattle during primary infection with Fasciola hepatica. Research in Veterinary Science 65, 169-171
10. Clery D., Torgerson P. & Mulcahy G. (1996) Immune responses of chronically infected adult cattle to Fasciola hepatica. Veterinary Parasitology 62, 71-82
11. Dalton J.P. & Brindley P.J. (1997) Protease of trematodes. In Advances in Trematode Biology, ed. B. Fried and T.K. Graczyk, pp. 265-308, CRC Press, Baton Raton and New York
12. Doy T.G., Hughes D.L. & Harness E. (1978) Resistance of the rat to infection with Fasciola hepatica and the possible involvement of intestinal eosinophil leucocytes. Research in Veterinary Science 25, 41-44
13. Fairweather I. (1999) Development of Fasciola hepatica in the mammalian host. In Fasciolosis, ed. J.P. Dalton, pp. 47-111, CAB International, Wallingford
14. Keegan P.S. & Trudgett A. (1992) Fasciola hepatica in the rat: immune responses associated with the development of resistance to infection. Parasite Immunology 14, 657-669
15. Lawrence R.A., Allen J.E., Osborne J. & Maizels R.M. (1994) Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting cytokine and Ig isotype responses in BALB/c mice. Immunology 153, 1216-1224
16. McCole D.F., Doherty M.L., Baird A.W. et al. (1998) Concanavalin A-stimulated proliferation of T cell subset-depleted lymphocyte populations isolated from Fasciola hepatica-infected cattle. Veterinary lmmunology and Immunopathology 66, 289-300
17. Mecusen E. & Brandon M. (1994) The use of antibody-secreting cells probes to reveal tissue-restricted immune responses during infection. European Journal of Immunology 17, 469-474
18. Melbourne E.A. & Howell M.J. (1990) Eosinophil responses to Fasciola hepatica in rodents. International Journal for Parasitology 20, 705-708
19. Milbourne E.A. & Howell M.J. (1993) Eosinophil differentiation in response to Fasciola hepatica and its excretory/secretory antigens. International Journal of Parasitology 23, 1005-1009
20. Mills K.H.G. (1996) Induction and detection of T cell responses. In Methods in Molecular Medicine-Vaccine Protocols, ed. A. Robinson, pp. 197-221, Humana Press Inc. NJ, USA
21. Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A. & Coffman R.L. (1986) Two types of murine helper T cell clone I. Definition according to profiles of lymphokine activities and secreted proteins. The Journal of Immunology 136, 2348-2357
22. Mosmann T.R. & Coffman (1989) Heterogeneity of cytokine secretion patterns and function of helper T cells. Advances in Immunology 46, 111-147
23. Mulcahy G., Joyce P. & Dalton J.P. (1999) Immunology of Faxciola hepatica infection. In Fasciolosis, ed. J.P. Dalton, pp. 341-376, CAB International, Wallingford
24. O'Garra A., McEvoy L.M. & Zlotnik A. (1998) T-cell subsets: chemokine receptors guide the way. Current Biology 8, R646-R649
25. O'Neill S.M., Parkinson M., Strauss W., Angles R. & Dalton J.P. (1998) Immunodiagnosis of Fasciola hepatica infection (Fasciolosis) in a human population in the Bolivian Altiplano using purified Cathepsin L cysteine proteinase. American Journal of Tropical Medicine and Hygiene 58, 417-423
26. Oldham G. & Williams L. (1985) Cell mediated immunity to liver fluke antigens during experimental Fasciola hepatica infection of cuttle. Parasite Immunology 7, 503-516
27. Pearce E.J., Vasconcelos J.P., Brunet L.R. & Sabin E.A. (1996) IL-4 in Schistosomiasis. Experimental Parasitology 84, 295-299
28. Sandman R.M. & Howell M.J. (1981) Response of sheep to challenge infection with Fasciola hepatica. The Journal of Parasitology 74, 818-820
29. Sher A. & Coffman R.L. (1992) Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annual Review of Immunology 10, 385-409
30. Sloan T., Dooge D. & Joyce P. (1991) Identification of phosphorylcholine containing antigens of Fasciola hepatica-successful tolerization against epitopes in experimental animals. Parasite Immunology 13, 447-455
31. Smith A., Dowd A., McGonigle S.M. et al. (1993) Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica. Molecular Biochemical Parasitology 62, 1-8
32. Spithill T.W. & Dalton J.P. (1998) Progress in the development of vaccines against Fasciolosis. Parasitology Today 14, 224-228
33. Stevens T.L., Bossie A., Sanders V.M. et al. (1988) Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334, 255-258
34. Zimmerman G.L., Kerkvliet N.I., Brauner J.A. & Cerro J.E. (1983) Modulation of host immune responses by Fasciola hepatica: responses by peripheral lymphocytes to mitogens during liver fluke infections of sheep. Journal of Parasitology 69, 473-477