Effects of sulfation on antithrombin-thrombin/factor Xa interactions in semisynthetic low molecular weight heparins

Seminars in Thrombosis and Hemostasis

Volumn 27, Issue 5, 2001, Pages 483-487

  Sissi, C ^a   Naggi, A ^a   Torri, G ^a   Palumbo, M ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Antithrombin; AT; AT heparin complexes; Factor Xa; Heparin; Low molecular weight (LMW) heparin; Sulfation

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; HEPARAN SULFATE; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX; THROMBIN INHIBITOR;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; DESULFURIZATION; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; DRUG SULFATION; ENZYME BINDING; ENZYME INHIBITOR INTERACTION; HUMAN; MOLECULAR WEIGHT; PRIORITY JOURNAL; QUANTITATIVE ASSAY; STATISTICAL ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTITHROMBINS; DRUG INTERACTIONS; FACTOR XA; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; INHIBITORY CONCENTRATION 50; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SULFATES; THROMBIN;

EID: 0034771722     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-17959     Document Type: Article

References (20)

1. Heparin
2. Proteoglycans: Structures and interactions
3. Structure and biological activity of heparin
4. Correlation between structure and function of heparin
5. Mechanism of heparin activation of antithrombin: Evidence for an induced-fit model of allosteric activation involving two interaction subsites
6. Mobile reactive centre of serpins and the control of thrombosis
7. Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding
8. Synthesis of thrombin-inhibiting heparin mimetics without side effects
9. The anticoagulant activation of antithrombin by heparin
10. "Supersulfated " heparin fragments, a new type of low-molecular weight heparin. Physicochemical and pharmacological properties
11. Generation of antifactor Xa active 3Osulfated glucosamine rich sequences by controlled desulfation of oversulfated heparins
12. Modulation of sulfation patterns of glycosaminoglycans
13. The size and shape of human and bovine antithrombin III
14. Transient kinetics of heparin-catalyzed protease inactivation by antithrombin III. Linkage of protease-inhibitor-heparin interactions in the reaction with thrombin
15. The preparation of activated factor X and its action on prothrombin
16. Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin
17. p-Aminobenzamidine as a fluorescent probe for the active site of serine proteases
18. Binding of heparin to human antithrombin III as studied by measurements of tryptophan fluorescence
19. Calcium enhances heparin catalysis of the thrombin-factor Xa reaction by a template mechanism. Evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa