Hydroxyl radical generation in oxygen-treated infants

Pediatrics

Volumn 100, Issue 4, 1997, Pages 700-704

  Lubec, Gert ^a   Widness, John A ^b   Hayde, Michael ^a   Menzel, Daniel ^a   Pollak, Arnold ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Hydroxyl radical; Infants; o tyrosine; Oxygen

Indexed keywords

3 (2 HYDROXYPHENYL)ALANINE; HYDROXYL RADICAL;

ARTICLE; CLINICAL ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTENSIVE CARE; LUNG INJURY; NEWBORN; OXYGEN THERAPY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RESPIRATORY TRACT DISEASE;

APGAR SCORE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROXYL RADICAL; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; OXYGEN; OXYGEN INHALATION THERAPY; PHENYLALANINE; REGRESSION ANALYSIS; TYROSINE;

EID: 0030830172     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.100.4.700     Document Type: Article

References (22)

1. Frank L. Effects of oxygen on the newborn. Fed Proc. 1985;44:2328-2834
2. Freeman BA, Crapo DJ. Hyperoxia causes increased oxygen radical production in rat lungs and rat mitochondria. J Biol Chem. 1981;256: 10986-10991
3. Freeman BA, Young SL, Crapo JD. Liposome mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. J Biol Chem. 1983;258:12534-12540
4. Evans HE, Rosenfeld W, Jhaveri R, Concepcion L, Zabaleta I. Oxidant mediated lung disease in newborn infants. Free Rad Biol Med. 1986;2: 369-372
5. Gerdes JS. Superoxide dismutase in prevention of bronchopulmonary dysplasia. J Pediatr. 1985;106:1057
6. Walther FJ, Kuipers IM, Pavlova Z, Willebrand D, Abuchowski A, Viau AT. Mitigation of pulmonary oxygen toxicity in premature lambs with intravenous antioxidants. Exp Lung Res. 1990;16:177-189
7. Pitkaenen OM, Hallmann M, Andersson SM. Correlation of free oxygen radical induced lipid peroxidation with outcome in very low birth weight infants. J Pediatr. 1990;116:760-764
8. Schlenzig JS, Bervoets K, Loewenich Vv, Boehles H. Urinary malondialdehyde concentration in preterm neonates: is there a relationship to disease entities of neonatal intensive care? Acta Paediatr. 1993;82:202-205
9. Zweier JL, Duke SS, Kuppusamy P, Sylvester JT, Gabrielson EW. Electron paramagnetic resonance evidence that cellular oxygen toxicity is caused by the generation of superoxide and hydroxyl free radicals. FEBS Lett. 1989;252:12-16
10. Kelly F, Lubec G. Hyperoxic injury of immature guinea pig lung is mediated via hydroxyl radicals. Pediatr Res. 1995;38:286-291
11. Rudolph AJ, Smith CA. Idiopathic respiratory distress syndrome of the newborn. J Pediatr. 1960;57:905-921
12. Bartosch B, Vycudilik W, Popow C, Lubec G. Urinary 3-hydroxyproline excretion in Alport syndrome: a noninvasive screening test? Arch Dis Child. 1991;66:259-262
13. Lubec B, Arbeiter K. The determination of the urinary D/L trans 3-hydroxyproline ratio: a noninvasive screening test for Alport syndrome. J Pediatr. 1993;123:748-751
14. Ishimitsu S, Fujimoto S, Ohara A. High performance liquid chromatographic determination of M-tyrosine and o-tyrosine in rat urine. J Chromatogr. 1989;489:377-383
15. Karam LM, Bergtold DS, Simic MG. Biomarkers of OH radical damage in vivo. Free Radic Res Commun. 1991;12:11-16
16. Ibe FI, Grinter R, Massey R, Homer R. Detection of o-tyrosine in irradiated chicken by reverse-phase HPLC and fluorescence detection. Food Addit Contam. 1991;8:787-792
17. Lubec G. The hydroxl radical: from chemistry to disease. J Invest Med. 1996;44:324-346
18. Langley SC, Kelly FJ. Different response of the glutathione system to fasting in neonatal and adult guinea pigs. Biochem Pharmacol. 1992;44: 1489-1494
19. 2. Am J Physiol. 1987;252: 693-698
20. Saugstad OD. Oxygen toxicity in the neonatal period. Acta Paediatr Scand. 1990;79:881-892
21. Miller RA, Britigan BE. The formation and biological significance of phagocyte-derived oxidants. J Invest Med. 1995;43:39-49
22. Du XH, Yang CL. Mechanism of gentamicine nephrotoxicity in rats and the protective effect of zinc-induced metallothionine synthesis. Nephrol Dial Transplant. 1994;9:135-140