Ubiquitin immunoreactivity in presumed spinal interneurones in motor neurone disease

Neuropathology and Applied Neurobiology

Volumn 27, Issue 5, 2001, Pages 352-361

  Stephens, B ^a   Navarrete, R ^a   Guiloff, R J ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

Amyotrophic lateral sclerosis; Anterior horn cell; Immunocytochemistry; Interneurone; Motor neurone; Motor neurone disease; Pathology; Ubiquitin

Indexed keywords

UBIQUITIN;

ADULT; AGED; ARTICLE; CELL COUNT; CELL INCLUSION; CELL SIZE; CELL STRUCTURE; CLINICAL ARTICLE; CONJUGATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; INTERNEURON; MALE; MOTONEURON; MOTOR NEURON DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SPINAL CORD NERVE CELL; SPINAL CORD VENTRAL HORN; STAINING;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANTERIOR HORN CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERNEURONS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; UBIQUITIN;

EID: 0034767865     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.2001.00354.x     Document Type: Article

References (29)

1. Ubiquitin, cellular inclusions and their role in neuro-degeneration
2. Motor neurons and neurofilaments in sickness and in health
3. Ubiquitin-dependent protein degradation
4. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures
5. Abnormal distribution of phosphorylated neurofilaments in neuronal degeneration induced by kainic acid
6. Amyotrophic lateral sclerosis: Current issues in classification, pathogenesis and molecular pathology
7. Familial amyotrophic lateral sclerosis with a mutation in exon 4 of the Cu/Zn superoxide dismutase gene: Pathological and immunocytochemical changes
8. Intranuclear inclusions in subtypes of striatal neurons in Huntington's disease transgenic mice
9. Ubiquitin deposits in anterior horn cells in motor neurone disease
10. Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis
11. A filamentous inclusion body within anterior horn neurones in motor neurone disease defined by immunocytochemical localisation of ubiquitin
12. Ubiquitin in neuro-degenerative diseases
13. Histochemical and immunocytochemical study of ubiquitinated neuronal inclusions in amyotrophic lateral sclerosis
14. Cytoplasmic inclusions in spinal neurons of the motor neuron degeneration (Mnd) mouse 1. Light microscopic analysis
15. Ubiquitin and neurofilament expression in anterior horn cells in amyotrophic lateral sclerosis: Possible clues to the pathogenesis
16. Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: Neurochemical correlates of selective vulnerability
17. Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice
18. Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis
19. Evidence for sequential degeneration of the neurons in the intermediate zone of the spinal cord in amyotrophic lateral sclerosis: A topographic and quantitative investigation
20. Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: A hypothesis
21. Ubiquitin in motor neuron disease: Study at the light and electron microscope level
22. Spinal cord: Cytoarchitectural, dendroarchitectural, and myeloarchitectural organization
23. Spinal interneuron loss in motor neuron disease
24. Aggregation of ubiquitin and a mutant ALS-linked SOD-1 protein correlate with disease progression and fragmentation of the Golgi apparatus
25. Disease-specific patterns of neuronal loss in the spinal ventral horn in amyotrophic lateral sclerosis, multiple system atrophy and X-linked recessive bulbospinal neuronopathy, with special reference to the loss of small neurons in the intermediate zone
26. Total numbers of limb motor neurones in the human lumbosacral cord and an analysis of the accuracy of various sampling procedures
27. The spinal cord in ALS. 140 autopsy cases, preliminary information
28. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions
29. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease