Fucosyltransferases: Structure/function studies

Glycobiology

Volumn 11, Issue 10, 2001, Pages

  De Vries, Theodora ^a   Knegtel, Ronald M A ^b   Holmes, Eric H ^c   Macher, Bruce A ^a  

^a SAN FRANCISCO STATE UNIVERSITY   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

^c NORTHWEST HOSPITAL   (United States)

Author keywords

Disulfide linkages; Fucosyltransferase; Function; Modeling; Structure

Indexed keywords

ALPHA 1,3 FUCOSYLTRANSFERASE; AMINO ACID; DISULFIDE; FUCOSYLTRANSFERASE; GLYCOCONJUGATE; GUANOSINE DIPHOSPHATE FUCOSE; NUCLEOTIDE;

AMINO ACID SEQUENCE; CELL ADHESION; CONTROLLED STUDY; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; FUCOSYLATION; HUMAN; HUMAN CELL; LYMPHOCYTE RECIRCULATION; METHODOLOGY; MOLECULAR CLONING; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; REVIEW;

EID: 0034755699     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/11.10.119R     Document Type: Review

References (75)

1. Fast protein fold recognition via sequence to structure alignment and contact capacity potentials
2. N-glycosylation site occupancy of rat α-1, 3-fucosyltransferase IV and the effect of glycosylation on enzymatic activity
3. 110-Gln) in the human FUT7 gene
4. The protein data bank
5. Sequence alignment and fold recognition of fucosyltransferases
6. Acceptor specificity of the human leukocyte α3 fucosyltransferase: Role of FucT-VII in the generation of selectin ligands
7. CHARMM: A program for macromolecular energy minimization and dynamics calculations
8. FUT4 and FUT9 genes are expressed early in human embryogenesis
9. Expression of human chromosome 19p α(1, 3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
10. The C-terminal N-glycosylation sites of the human α1, 3/4-fucosyltransferase III, -V, and -VI (hFucTIII, -V, and -VI) are necessary for the expression of full enzyme activity
11. Evolution of fucosyltransferase genes in vertebrates
12. Advances in molecular genetics of α-2- and α-3/4-fucosyl-transferases
13. Occurrence and specificities of α 3-fucosyltransferases
14. Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures
15. A single amino acid in the hypervariable stem domain of vertebrate α1, 3/4-fucosyltransferases determines the type 1/type 2 transfer. Characterization of acceptor substrate specificity of the lewis enzyme by site-directed mutagenesis
16. Genotypic heterogeneity among Lewis negative individuals
17. Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human α(1, 3/1, 4)-fucosyltransferase, Fuc-TIII
18. Identification of two functionally deficient plasma α3 fucosyltransferase (FUT6) alleles
19. Hybrid fold recognition: Combining sequence derived properties with evolutionary information
20. Protein fold recognition using sequence-derived predictions
21. Assigning amino acid sequences to 3-dimensional protein folds
22. Crystal structures of the bovine β4-galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose
23. Molecular cloning, expression, chromosomal assignment, and tissue-specific expression of a murine α(1, 3)-fucosyltransferase locus corresponding to the human ELAM-1 ligand fucosyltransferase
24. ELFT: A gene that directs the expression of an ELAM-1 ligand
25. 178 in FucT IV
26. Human α3/4 Fucosyltransferases: Characterization of highly conserved cysteine residues and N-linked glycosylation sites
27. α1, 3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX
28. Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals
29. The cloning and expression of a human α1, 3-fucosyltransferase capable of forming the E-selectin ligand
30. A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group α(1-3/4)FT
31. Cloning of a human α(1, 3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on chinese hamster ovary cell transfectants
32. Human α(1, 3/1, 4)-fucosyltransferases discriminate between different oligosaccharide acceptor substrates through a discrete peptide fragment
33. Selectin ligands, leukocyte trafficking, and fucosyltransferase genes
34. Molecular cloning of a human fucosyltransferase gene that determines expression of the LewisX and VIM-2 epitopes but not ELAM-1 dependent cell adhesion
35. Human α1-3 fucosyltransferases
36. The α(1, 3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis
37. Lewis X biosynthesis in Helicobacter pylori. Molecular cloning of an α(1, 3)-fucosyltransferase gene
38. Physical maps of human α(1, 3)-fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21
39. The crystal structure of dihydrodipicolinate synthase from Escherichia coli at 2.5 A resolution
40. Acceptor specificity and tissue distribution of three human α-3-fucosyl-transferases
41. Molecular basis for plasma α(1, 3)-fucosyltransferase gene deficiency (FUT6)
42. Molecular basis for Lewis α(1, 3/1, 4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees
43. Molecular genetics of H, Se, Lewis and other fucosyltransferase genes
44. Molecular cloning of a cDNA encoding a novel human leukocyte α1, 3-fucosyltransferase capable of synthesizing the sialyl LewisX determinant
45. Human α1, 3/4-fucosyltransferases. I. Identification of amino acids involved in acceptor substrate binding by site-directed mutagenesis
46. Complementary acceptor and site specificities of Fuc-TIV and Fuc-TVII allow effective biosynthesis of sialyl-TriLex and related polylactosamines present on counterreceptors of selectins
47. α(1, 3/1, 4)Fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals
48. Molecular genetic analysis of the human Lewis histo-blood group system
49. Divergent evolution of fucosyltransferase genes from vertebrates, invertebrates, and bacteria
50. Influence of Lewis α1 -3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels
51. Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa
52. Significance of each of three missense mutations, G484A, G667A, and G808A, present in an inactive allele of the human Lewis gene (FUT3) for α(1, 3/1, 4)fucosyl-transferase inactivation
53. Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation
54. The gene encoding myeloid α3-fucosyltransferase (FUT4) is located between D1 1S388 and D11S919 on 11q21
55. Fucosyltransferase genes are dispersed in the genome: FUT7 is located on 9q34.3 distal to D9S1830
56. + induces local and long-range changes in the three-dimensional structure of the tryptophan synthase α2β2 complex
57. Comparative protein modelling by satisfaction of spatial restraints
58. Expression cloning of a novel α1, 3-fucosyltransferase that is involved in biosynthesis of the sialyl LewisX carbohydrate determinants in leukocytes
59. Localization of α1, 3-fucosyltransferase VI in Weibel-Palade bodies of human cells
60. Human α3/4-fucosyltransferases. III. A Lys/Arg residue located within the α3-FucT motif is required for activity but not substrate binding
61. 300 in FucT-IV
62. Expression and transcriptional regulation of the human α1, 3-fucosyltransferase 4 (FUT4) gene in myeloid and colon adenocarcinoma cell lines
63. Glycosyltransferase structure and mechanism
64. Human α1, 3/4-fucosyltransferases. II. A single amino acid at the COOH terminus of FucT III and V alters their kinetic properties
65. Crystal structure of the DNA modifying enzyme β-glucosyltransferase in the presence and absence of the substrate uridine diphosphoglucose
66. Potent induction of α(1, 3)-fucosyl-transferase VII in activated CD4+ T cells by TGF-β1 through a p38 mitogen-activated protein kinase-dependent pathway
67. Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on α1, 3-fucosyltransferase VII gene expression
68. Specialized contributions by FucT-IV and FucT-VII during leukocyte rolling in dermal microvessels
69. An atlas of protein toplogy cartoons available on the World Wide Web
70. Isolation of a novel human α(1, 3)fucosyltransferase gene and molecular comparison to the human Lewis blood group α(1, 3/1, 4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with specificities
71. Molecular cloning of a fourth member of a human α(1, 3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the LewisX, sialyl LewisX, and difucosyl sialyl LewisX epitopes
72. Integration of MAP kinase signal transduction pathways at the serum response element
73. Human α(1, 3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line
74. Structure-function analysis of human α1, 3-fucosyltransferase. Amino acids involved in acceptor substrate specificity
75. New scoring schemes for protein fold recognition based on Voronoi contacts