Human α1,3/4-fucosyltransferases: III. A LYS/ARG residue located within the α1,3-FucT motif is required for activity but not substrate binding

Journal of Biological Chemistry

Volumn 273, Issue 39, 1998, Pages 25256-25260

  Sherwood, Anne L ^a   Nguyen, Anton T ^b   Whitaker, Jeffery M ^b   Macher, Bruce A ^b   Stroud, Mark R ^a   Holmes, Eric H ^a  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^b SAN FRANCISCO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DNA; FUCOSYLTRANSFERASE; GUANOSINE DIPHOSPHATE FUCOSE; LYSINE; GALACTOSIDE 3(4) LEVO FUCOSYLTRANSFERASE; GALACTOSIDE 3(4)-L-FUCOSYLTRANSFERASE; PRIMER DNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; CHEMISTRY; DRUG ANTAGONISM; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ARGININE; BASE SEQUENCE; DNA PRIMERS; FUCOSYLTRANSFERASES; HUMANS; KINETICS; LYSINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0032566438     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.39.25256     Document Type: Article

References (36)

1. Kukowska-Latallo, J., Larsen, R. D., Nair, R. P., and Lowe, J. B. (1990) Genes Dev. 4, 1288-1303
2. Goelz, S. E., Hession, C., Goff, D., Griffiths, B., Tizard, R., Newman, B., Chi-Rosso, G., and Lobb, R. (1990) Cell 63, 1349-1356
3. Weston, B. W., Nair, R. P., Larsen, R. D., and Lowe, J. B. (1992) J. Biol. Chem. 267, 4152-4160
4. Koszdin, K. L., and Bowen, B. R. (1992) Biochem. Biophys. Res. Commun. 187, 152-157
5. Weston, B. W., Smith, P. L., Kelly, R. J., and Lowe, J. B. (1992) J. Biol. Chem. 267, 24575-24584
6. Sasaki, K., Kurata, K., Funayama, K., Nagata, M., Watanabe, E., Ohta, S., Hanai, N., and Nishi, T. (1994) J. Biol. Chem. 269, 14730-14737
7. Natsuka, S., Gersten, K. M., Zenita, K., Kannagi, R., and Lowe, J. B. (1994) J. Biol. Chem. 269, 16789-16794
8. Hadwiger, J. A., Wilkie, T. M., Strathmann, M., and Firtel, R. A. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 8213-8217
9. Gersten, K. M., Natsuka, S., Trinchera, M., Petryniak, B., Kelly, R. J., Hirarwa, N., Jenkens, N. A., Gilbert, D. J., Copeland, N. G., and Lowe, J. B. (1995) J. Biol. Chem. 270, 25047-25056
10. Smith, P. L., Gersten, K. M., Petryniak, B., Kelly, R. J., Rogers, C., Natsuka, Y., Alford, J. A., III, Scheidegger, E. P., Natsuka, S., and Lowe, J. B. (1996) J. Biol. Chem. 271, 8250-8259
11. Ozawa, M., and Muramatsu, T (1996) J. Biochem. (Tokyo) 119, 302-308
12. Oulmouden, A., Wierinckx, A., Petit, J. M., Costache, M., Palcic, M. M., Mollicone, R., Oriol, R., and Julien, R. (1997) J. Biol. Chem. 272, 8764-8773
13. Lee, K. P., Carlson, L. M., Woodcock, J. B., Ramachandra, N., Schultz, T. L., Davis, T. A., Lowe, J. B., Thompson, C. B., and Larsen, J. B. (1996) J. Biol. Chem. 271, 32960-32967
14. Sajdel-Sulkowska, E. M., Smith, F. I., Wiederschain, G., and McCluer, R. H. (1997) Glycoconj. J. 14, 249-258
15. Martin, S. L., Edbrooke, M. R., Hodgman, T. C., van den Eijnden, D. H., and Bird, M. I. (1997) J. Biol. Chem. 272, 21349-21356
16. Ge, Z., Chan, N. W. C., Palcic, M. M., and Taylor, D. E. (1997) J. Biol. Chem. 272, 21357-21363
17. Holmes, E. H. (1992) Arch. Biochem. Biophys. 296, 562-568
18. Chien, J. L., Li, S.-C., Laine, R. A., and Li, Y.-T. (1978) J. Biol. Chem. 253, 4031-4035
19. Higuchi, R. (1990) in PCR Protocols: A Guide to Methods and Applications, pp. 177-183, Academic Press, Inc., New York
20. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. (eds) (1993) Current Protocols in Molecular Biology, John Wiley & Sons, Inc., New York
21. Holmes, E. H., Xu, Z., Sherwood, A. L., and Macher, B. A. (1995) J. Biol. Chem. 270, 8145-8151
22. Stroud, M. R., and Holmes, E. H. (1997) Biochem. Biophys. Res. Commun. 238, 165-168
23. Nishihara, S., Yazawa, S., Iwasaki, H., Nakazato, M., Kudo, T., Ando, T., and Narimatsu, H. (1993) Biochem. Biophys. Res. Commun. 196, 624-631
24. Mollicone, R., Reguigne, I., Fletcher, A., Aziz, A., Rustam, M., Weston, B. W., Kelly, R. J., Lowe, J. B., and Oriol, R. (1994) J. Biol. Chem. 269, 12662-12671
25. Mollicone, R., Reguigne, I., Kelly, R. J., Fletcher, A., Watt, J., Chatfield, S., Aziz, A., Cameron, H. S., Weston, B. W., Lowe, J. B., and Oriol, R. (1994) J. Biol. Chem. 269, 20987-20994
26. De Vries, T., Srnka, C. A., Palcic, M. M., Swiedler, S. L., van den Eijnden, D. H., and Macher, B. A. (1995) J. Biol. Chem. 270, 8712-8722
27. Legault, D. J., Kelly, R. J., Natsuka, Y., and Lowe, J. B. (1995) J. Biol. Chem. 270, 20987-20996
28. Xu, Z., Vo, L., and Macher, B. A. (1996) J. Biol. Chem. 271, 8818-8823
29. Brinkman-Van der Linden, E. C. M., Mollicone, R., Oriol, R., Larson, G., van den Eijnden, D. H., and Van Dijk, W. A. (1996) J. Biol. Chem. 271, 14492-14495
30. Orntoft, T. F., Vestergaard, E. M., Holmes, E., Jakobsen, J. S., Grunnet, N., Mortensen, M., Johnson, P., Bross, P., Gregersen, N., Skorstengaard, K., Jensen, U. B., Bolund, L., and Wolf, H. (1996) J. Biol. Chem. 271, 32260-32268
31. Britten, C. J., and Bird, M. I. (1997) Biochim. Biophys. Acta 1334, 57-64
32. Elmgren, A., Mollicone, R., Costache, M., Börjeson, C., Oriol, R., Harrington, J., and Larson, G. (1997) J. Biol. Chem. 272, 21994-21998
33. Hindsgaul, O., Kaur, K. J., Srivastava, G., Blaszczyk-Thurin, M., Crawley, S. C., Heerze, L. D., and Palcic, M. M. (1991) J. Biol. Chem. 266, 17858-17862
34. Nguyen, A. T., Holmes, E. H., Whitaker, J. M., Ho, S., Shetterly, S., and Macher, B. A. (1998) J. Biol. Chem. 273, 25244-25249
35. IUPAC-IUB Commission on Biochemical Nomenclature (1977) Lipids 12, 455-463
36. Vo, L., Lee, S., Marcinko, M. C., Holmes, E. H., and Macher, B. A. (1998) J. Biol. Chem. 273, 25250-25255