Limited proteolysis of filamin is catalyzed by caspase-3 in U937 and Jurkat cells

Journal of Biochemistry

Volumn 130, Issue 4, 2001, Pages 535-542

  Umeda, Tatsuya ^a   Kouchi, Zen ^a   Kawahara, Hiroyuki ^a   Tomioka, Shigeo ^a   Sasagawa, Noboru ^a   Maeda, Tatsuya ^a   Sorimachi, Hiroyuki ^a   Ishiura, Shoichi ^a   Suzuki, Koichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptosis; Caspase 3; Cytoskeleton; Filamin; Proteolysis

Indexed keywords

CASPASE 3; FILAMIN;

APOPTOSIS; ARTICLE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; PICHIA PASTORIS; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

EID: 0034753502     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003016     Document Type: Article

References (52)

1. Cell death: The significance of apoptosis
2. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
3. Apoptosis: Mechanisms and roles in pathology
4. Social controls on cell survival and cell death
5. Apoptosis and programmed cell death in immunity
6. ICE-related proteases in apoptosis
7. Genetic control of programmed cell death in the nematode C. elegans
8. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
9. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
10. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
11. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme
12. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitate protease that cleaves the death substrate poly(ADP-ribose) polymerase
13. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
14. A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells
15. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases
16. Identification and characterization of ICH-2, a novel member of the interleukin-1 β-converting enzyme family of cysteine proteases
17. Mch3, a novel human apoptotic cysteine protease highly related to CPP32
18. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family
19. Human ICE/CED-3 protease nomenclature
20. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis
21. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B
22. Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32
23. Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE
24. RAIDD is a new 'death' adaptor molecule
25. Target protease specificity of the viral serpin CrmA. Analysis of five caspases
26. ERICE, a novel FLICE-activatable caspase
27. Caspase-14 is a novel developmentally regulated protease
28. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase
29. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis
30. The restrictive proteolysis of alpha-fodrin to a 120 kDa fragment is not catalyzed by calpains during thymic apoptosis
31. Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis
32. Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis
33. Proteolytic activation of protein kinase C delta and epsilon by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis
34. A rapid purification of alpha-actinin, filamin, and a 130,000-dalton protein from smooth muscle
35. Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease
36. Simultaneous degradation of alphaII- and betaII-spectrin by caspase 3 (CPP32) in apoptotic cells
37. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): A molecular leaf spring
38. Increase in the level of m-calpain correlates with the elevated cleavage of filamin during myogenic differentiation of embryonic muscle cells
39. Correlation between inhibition of cytoskeleton proteolysis and anti-vesiculation effect of calpeptin during A23187-induced activation of human platelets: Are vesicles shed by filopod fragmentation?
40. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
41. Calpain abolishes the effect of filamin on the actomyosin system in platelets
42. Calpain activation in apoptosis
43. Calpain activation in apoptosis
44. Differential signaling pathways following oxidative stress in mutant myotonin protein kinase cDNA-transfected C2C12 cell lines
45. In situ phosphorylation of platelet actin-binding protein by cAMP-dependent protein kinase stabilizes it against proteolysis by calpain
46. Determination of a cAMP-dependent protein kinase phosphorylation site in the C-terminal region of human endothelial actin-binding protein
47. Caspases: The executioners of apoptosis
48. Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18
49. Interaction of presenilins with the filamin family of actin-binding proteins
50. An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
51. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells
52. Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia