mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency

EMBO Journal

Volumn 15, Issue 20, 1996, Pages 5726-5736

  Cui, Ying ^a   Dinman, Jonathan D ^a   Peltz, Stuart W ^a  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Frameshifting; mRNA decay; Nonsense mutation; Ribosome; Translation

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA GALACTOSIDASE; GENE PRODUCT; MESSENGER RNA; PAROMOMYCIN;

ALLELE; ANTIBIOTIC SENSITIVITY; ARTICLE; CHROMOSOME MUTATION; DEFECTIVE VIRUS; FRAMESHIFT MUTATION; GENE MUTATION; PRIORITY JOURNAL; RNA METABOLISM; SACCHAROMYCES CEREVISIAE; YEAST CELL;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE VIRUS L-A (L1); SATELLITE VIRUSES;

EID: 0029854442     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00956.x     Document Type: Article

References (33)

1. Altamura, N., Groudinsky, O., Dujardin, G. and Slonimski, P.P. (1992) NAM7 nuclear gene encodes a novel member of a family of helicases with a Zl-6n-ligand motif and is involved in mitochondrial functions in Saccharomyces cerevisiae. J. Mol. Biol., 224, 575-587.
2. Chandler, M. and Fayet, O. (1993) Translational frameshifting in the control of transposition in bacteria. Mol. Microbiol., 7, 497-503.
3. Cheng, R.H. et al. (1994) Fungal virus capsids, cytoplasmic compartments for the replication of double-stranded RNA, formed as icosahedral shells of asymmetric Gag dimers. J. Mol. Biol., 224, 255-258.
4. Christianson, T.W., Sikorski, R.S., Dante, M., Shero, J.H. and Hieter, P. (1992) Multifunctional yeast high-copy-number shuttle vectors. Gene, 110, 119-122.
5. Cui, Y., Hagan, K.W., Zhang, S. and Peltz, S.W. (1995) Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev., 9, 423-436.
6. Czaplinski, K., Weng, Y., Hagan, K. and Peltz, S.W. (1995) Purification and characterization of the Upf1 protein: a factor involved in translation and mRNA degradation. RNA, 1, 610-623.
7. Dinman, J.D. (1995) Ribosomal frameshifting in yeast viruses. Yeast, 11, 1115-1127.
8. 1 double-stranded RNA virus propagation. J. Virol., 66, 3669-3676.
9. Dinman, J.D. and Wickner, R.B. (1994). Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered-1 ribosomal frameshifting efficiencies. Genetics, 136, 75-86.
10. Dinman, J.D., Icho, T. and Wickner, R.B. (1991) A-1 ribosomal frameshift in a double-stranded RNA virus of yeast forms a Gag-pol fusion protein. Proc. Natl Acad. Sci. USA, 88, 174-178.
11. Farabaugh, P.J. (1995) Post-transcriptional regulation by Ty retrotransposon of Saccharomyces cerevisiae. J. Biol. Chem. 270, 10361-10364.
12. Fried, H.M. and Fink, G.R. (1978) Electron microscopic heteroduplex analysis of 'killer' double-stranded RNA species from yeast. Proc. Natl Acad. Sci. USA, 75, 4224-4228.
13. Hagan, K.W., Ruiz-Echevarria, M.J., Quan, Y. and Peltz, S.W. (1995) Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover. Mol. Cell. Biol., 15, 809-823.
14. Hayashi, S.-I. and Murakami, Y. (1995) Rapid and regulated degradation of ornithine decarboxylase. Biochem. J., 306, 1-10.
15. He, F. and Jacobson, A. (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway using an interacting protein screen. Genes Dev., 9, 437-454.
16. He, F. Peltz, S.W., Donahue, J.L., Rosbash, M. and Jacobson, A. (1993) Stabilization and ribosome association of unspliced pre-mRNA in a yeast upf-mutant. Proc. Natl Acad. Sci. USA, 90, 7034-7038.
17. Jacobson, A. and Peltz, S.W. (1996) Interrelationship of the pathways of mRNA decay and translation in eucaryotic cells. Annu. Rev. Biochem., in press.
18. Koonin, E.V. (1992) A new group of putative RNA helicases. Trends Biochem. Sci., 17, 495-497.
19. Lee, S.I., Umen, J.G. and Varmus, H.E. (1995) A genetic screen identifies cellular factors involved in retroviral -1 frameshifting. Proc. Natl Acad. Sci. USA, 92, 6587-6591.
20. Leeds, P., Peltz, S.W. Jacobson, A. and Culbertson, M.R. (1991) The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev., 5, 2303-2314.
21. Leeds, P., Wood, J.M., Lee, B.-S. and Culbertson, M.R. (1992) Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol. Cell. Biol., 12, 2165-2177.
22. Maquat, L.E. (1995) When cells slop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. RNA, 1, 453-465.
23. Masison, D.C., Blanc, A., Ribas, J.C., Carroll, K., Sonenberg, N. and Wickner, R.B. (1995) Decoying the cap-mRNA degradation system by a double-stranded RNA virus and poly(A)-mRNA surveillance by a yeast antiviral system. Mol. Cell. Biol., 15, 2763-2771.
24. Palmer, E., Wilhelm, J. and Sherman, F. (1979) Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotics. Nature, 277, 148-150.
25. Peltz, S.W., Brown, A.H. and Jacobson, A. (1993) mRNA destabilization triggered by premature translational termination depends on three mRNA sequence elements and at least one trans-acting factor. Genes Dev., 7, 1737-1754.
26. Peltz, S.W., He, F., Welch, E. and Jacobson, A. (1994) Nonsense-mediated mRNA decay in yeast. Prog. Nucleic Acid Res. Mol. Biol., 47, 271-298.
27. Rose, M.D., Winston, F. and Hieter, P. (1990) Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY.
28. Singh, A., Ursic, D. and Davies, J. (1979) Phenotypic suppression and misreading in Saccharomyces cerevisiae. Nature, 277, 146-148.
29. Weng, Y., Ruiz-Echevarria, M.J., Zhang, S., Cui, Y., Czaplinski, K., Dinman, J.D. and Peltz, S.W. (1996a) Characterization of the nonsense-mediated mRNA decay pathway and its effect on modulating translation termination and frameshifting. Modern Cell Biol., in press.
30. Weng, Y., Czaplinski, K. and Peltz, S.W. (1996b) Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex, but not mRNA turnover. Mol. Cell Biol., in press.
31. Wickner, R.B. (1993) Double-stranded RNA virus replication and packaging. J. Biol. Chem., 268, 3797-3800.
32. - phenotype. J. Virol., 65, 151-161.
33. Zhang, S., Ruiz-Echevarria, M.J., Quan, Y. and Peltz, S.W. (1995) Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay. Mol. Cell. Biol., 15, 2231-2244.