Prevalence, characteristics and diabetes risk associated with transient maternally acquired islet antibodies and persistent islet antibodies in offspring of parents with type 1 diabetes

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 10, 2001, Pages 4826-4833

  Naserke, Heike E ^a   Bonifacio, Ezio ^c   Ziegler, Anette G ^a,b  

^a INSTITUT FÜR DIABETESFORSCHUNG   (Germany)

^b Klinikum Schwabing   (Germany)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DECARBOXYLASE; IMMUNOGLOBULIN G1; INSULIN ANTIBODY; MATERNAL ANTIBODY; PHOSPHATASE;

ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PANCREAS ISLET; PREVALENCE; PRIORITY JOURNAL; PROGENY; PROGNOSIS; RISK ASSESSMENT; SCREENING;

AUTOANTIBODIES; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; EPITOPES; FEMALE; FETAL BLOOD; GLUTAMATE DECARBOXYLASE; HUMANS; INFANT; INFANT, NEWBORN; MALE; PREGNANCY; PREGNANCY IN DIABETICS; RISK;

EID: 0034749462     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.10.4826     Document Type: Article

References (24)

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2. Evidence for a long prediabetic period in type 1 (insulin-dependent) diabetes mellitus
3. Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives
4. Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2β predict immune-mediated (type 1) diabetes in relatives
5. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2-year analysis of the German BABYDIAB Study
6. Newborn screening for HLA markers associated with IDDM: Diabetes autoimmunity study in the young (DAISY)
7. The "Sardinia-IDDM study:" An attempt to unravel the cause of insulin-dependent diabetes mellitus in one of the countries with the highest incidence of the disease in the world
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10. On the appearance of islet associated autoimmunity in offspring of diabetic mothers: A prospective study from birth
11. Perinatal autoimmunity in offspring of diabetic parents. The german multicenter BABY-DIAB study: Detection of humoral immune responses to islet antigens in early childhood
12. Postnatal elimination of transplacentally acquired disease-associated antibodies in infants born to families with type 1 diabetes
13. Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation
14. Exposure to exogenous insulin promotes IgG1 and the T-helper 2-associated IgG4 responses to insulin but not to other islet autoantigens
15. Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type 1 diabetes
16. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes
17. Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody
18. Transient antiislet autoantibodies: Infrequent occurrence and lack of association with "genetic" risk factors
19. Half-life of the maternal IgG1 allotype in infants
20. Isolation and characterization of an Fc receptor from neonatal rat small intestine
21. Evidence for the sorting of endocytic vesicle contents during the receptor-mediated transport of IgG across the newborn rat intestine
22. Course of islet autoantibody titers during Ig-immunoadsorption in a patient with newly diagnosed type 1 diabetes
23. Microchimerism of maternal origin persists into adult life