Microchimerism of maternal origin persists into adult life

Journal of Clinical Investigation

Volumn 104, Issue 1, 1999, Pages 41-47

  Maloney, Sean ^a   Smith, Anajane ^a   Furst, Daniel E ^b   Myerson, David ^a   Rupert, Kate ^c   Evans, Paul C ^d   Nelson, J Lee ^a,e  

^a Fred Hutchinson Cancer Research Center   (United States)

^b BENAROYA RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d BABRAHAM INSTITUTE   (United Kingdom)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; AUTOIMMUNE DISEASE; DNA DETERMINATION; HLA SYSTEM; HUMAN; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MICROCHIMERISM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCLERODERMA;

EID: 0032717523     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI6611     Document Type: Article

References (38)

1. Lo, Y.M.D., et al. 1996. Two-way cell traffic between mother and fetus: biologic and clinical implications. Blood. 88:4390-4395.
2. Hall, J.M., et al. 1995. Detection of maternal cells in human umbilical cord blood using fluorescence in situ hybridization. Blood. 86:2829-2832.
3. Bianchi, D.W., Zickwolf, G.K., Weil, G.J., Sylvester, S., and DeMaria, M.A. 1996. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc. Natl. Acad. Sci. USA. 93:705-708.
4. Pollack, M.S., Kirpatrick, D., Kapoor, D., Supor, V., and O'Reilly, R.J. 1982. Identification by HLA typing of intrauterine derived maternal T cells in four patients with severe combined immunodeficiency. N. Engl. J. Med. 307:662-666.
5. Nelson, J.L. 1996. Viewpoint. Maternal-fetal immunology and autoimmune disease. Is some autoimmune disease auto-alloimmune or alloautoimmune? Arthritis Rheum. 39:191-194.
6. Nelson, J.L., et al. 1998. Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet. 351:559-562.
7. Lee, T.-H., Paglieroni, T., Ohto, H., Holland, P.V., and Busch, M.P. 1999. Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. Blood. 93:3127-3139.
8. DeMoor, G., Noens, L., and De Bic, S. 1988. A new case of human chimerism detected after pregnancy: 46, XY karyotype in the lymphocytes of a woman. Acta. Clin. Belg. 43:86-93.
9. Nelson, J.L., et al. 1993. Maternal-fetal disparity in HLA class II alloantigens and the pregnancy-induced amelioration of rheumatoid arthritis. N. Engl. J. Med. 329:466-471.
10. Mickelson, E., Smith, A., McKinney, S., Anderson, G., and Hansen, J.A. 1993. A comparative study of HLA-DRB1 typing by standard serology and hybridization of non-radioactive sequence-specific oligonucleotide probes to PCR-amplified DNA. Tissue Antigens. 41:86-93.
11. Smith, A.G., et al. 1996. Six new DR52-associated DRB1 alleles, three of DR8, rwo of DR11, and one of DR6, reflect a variety of mechanisms which generate polymorphism in the MHC. Tissue Antigens. 48:118-126.
12. Bodmer, J.G., et al. 1999. Nomenclature for factors of the HLA system 1998. Tissue Antigens. 53:407-446.
13. Petersdorf, E.W., and Hansen, J.A. 1995. A comprehensive approach for typing the alleles of the HLA-B locus by automated sequencing. Tissue Antigens. 46:73-85.
14. Schulman, H.M., et al. 1999. The biologic significance of rare peripheral blasts after hematopoietic cell transplant is predicted by multidimensional flow chemistry. Am. J. Clin. Pathol. In press.
15. Wayne, J.S., and Willard, H.F. 1985. Chromosome-specific alpha satellite DNA: nucleotide sequence analysis of the 2.0 kilobasepair repeat from the human X chromosome. Nucleic Acids Res. 13:2731-2743.
16. Lau, Y.F., Huang, J.C., Dozy, A.M., and Kan, Y.W. 1984. A rapid screening test for antenatal sex determination. Lancet. 1:14-16.
17. Evans, P.C., et al. 1999. Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma. Blood. 93:2033-2037.
18. Socie, G., et al. 1994. Search for maternal cells in human umbilical cord blood by polymerase chain reaction amplification of two minisatellite sequences. Blood. 83:340-344.
19. Petit, T., et al. 1997. Detection of maternal cells in human fetal blood during the third trimester of pregnancy usingallele-specific PCR amplification. Br. J. Haematol. 98:767-771.
20. Lo, Y.M.D., Hjelm, N.M., and Thilaganathan, B. 1998. Transfer of nucleated maternal cells into fetal circulation during the second trimester of pregnancy. Br. J. Haematol. 100:605-618.
21. Knobloch, C., Goldmann, S., and Friedrich, W. 1991. Limited T cell receptor diversity of transplacentally acquired maternal T cells in severe combined immunodeficiency. J. Immunol. 146:4157-4164.
22. Vaidya, S., et al. 1991. Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal-fetal T cell engraftment. Am. J. Pediatr. Hematol. Oncol. 13:172-175.
23. Wirt, D., et al. 1989. Novel T-lymphocyte population in combined immunodeficiency with features of graft-versus-host disease. N. Engl. J. Med. 321:370-374.
24. Bastian, J.F., Williams, R.A., Ornelas, W., Tani, P., and Thompson, L.F. 1984. Maternal isoimmunization resulting in combined immunodeficiency and fatal graft-versus-host disease in an infant. Lancet. 1:1435-1437.
25. Pollack, M.S., et al. 1980. DR-positive maternal engrafted T cells in a severe combined immunodeficiency patient without graft-versus-host disease. Transplantation. 30:331-334.
26. Hansen, J.A., Good, R.A., and DuPont, B. 1977. HLA-D compatibility between parents and child: increased occurrence in severe combined immunodeficiency and other hematopoietic diseases. Transplantation. 23:366-374.
27. Hutchinson, D.L., Turner, J.H., and Schlesinger, E.R. 1971. Persistence of donor cells in neonates after fetal and exchange transfusion. Am. J. Obstet. Gynecol. 109:281-284.
28. Piotrowski, P., and Croy, B.A. 1996. Maternal cells are widely distributed in murine fetuses in utero. Biol. Reprod. 54:1103-1110.
29. Gleichman, E., Van Elven, H., and Van der Veen, J.P. 1982. A systemic lupus erythematosus (SLE)-like disease in mice induced by abnormal T-B cell cooperation. Eur. J. Immunol. 12:152-155.
30. Portanova, J.P., Claman, H.N., and Kotzin, B.L. 1985. Autoimmunization in murine graft-vs-host disease. I. Selective production of antibodies to histones and DNA. J. Immunol. 135:3580-3586.
31. Portanova, J.P., Ebling, F.M., Hammond, W.S., Hahn, B.H., and Kotzin, B.L. 1988. Allogeneic MHC antigen requirements for lupus-like autoantibody production and nephritis in murine graft-vs-host disease. J. Immunol. 141:3370-3376.
32. Nelson, J.L. 1998. Microchimerism and autoimmune disease. N. Engl. J. Med. 338:1224-1225.
33. Aractingi, S., et al,. 1998. Fetal DNA in skin of polymorphic eruptions of pregnancy. Lancet. 352:1898-1901.
34. Artlett, C.M., Smith, B.J., and Jimenez, S. 1998. Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis N. Engl. J. Med. 338:1186-1191.
35. Starzl, T.E., and Zinkernagel, R.M. 1998. Antigen localization and migration in immunity and tolerance. N. Engl. J. Med. 339:1905-1913.
36. Claas, F., Gijbels, Y., van der velden-de Munck, J., and van Rood, J. 1988. Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life. Science. 241:1815-1817.
37. Holzgreve, W., et al. 1998. Disturbed feto-maternal cell traffic in preeclampsia. Obstet. Gynecol. 91:669-672.
38. Starzl, T.E., et al. 1992. Systematic chimerism in human female recipients of male livers. Lancet. 340:876-877.