Human macrophage metalloelastase (MMP-12) expression is induced in chondrocytes during fetal development and malignant transformation

Bone

Volumn 29, Issue 5, 2001, Pages 487-493

  KerkelA E ^a   Bohling T ^a   Herva, R ^b   Uria, J A ^c   Saarialho Kere, U ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Bone; Cartilage; Chondrosarcoma; Collagenase 3; Embryogenesis; Metalloproteinase (MMP)

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COLLAGENASE 3; MACROPHAGE ELASTASE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BONE DEVELOPMENT; CARTILAGE; CARTILAGE CELL; CHONDROSARCOMA; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME INDUCTION; FETUS; FETUS DEVELOPMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIMB; MACROPHAGE; PERIOSTEUM; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIB; SPINE;

BONE NEOPLASMS; CARTILAGE; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHONDROCYTES; CHONDROSARCOMA; COLLAGENASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MACROPHAGES; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 13; METALLOENDOPEPTIDASES; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034748677     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(01)00595-6     Document Type: Article

References (50)

1. Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors
2. Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression
3. Matrix metalloproteinases; A review
4. Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein
5. Matrix metalloproteinases generate angiostatin; Effects on neovascularization
6. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms
7. MMP-13 is induced during chondrocyte hypertrophy
8. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma
9. Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages
10. Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level
11. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage metalloelastase
12. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
13. Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme
14. Change in cellular localization of a rheumatoid arthritis-related antigen (RA-A47) with downregulation upon stimulation by inflammatory cytokines in chondrocytes
15. Discovery and analysis of inflammatory disease-related genes using cDNA microarrays
16. Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response
17. Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII
18. Cartilage proteoglycan degradation by a mouse transformed macrophage cell line is mediated by macrophage metalloelastase
19. Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck
20. Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development
21. Matrix metalloproteinases and their inhibitors in tumour growth and invasion
22. Matrix metalloproteinases in blood vessel development in human fetal skin and in cutaneous tumors
23. Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas
24. Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer
25. Matrix metalloproteinases (MMPs) and their physiological inhibitors (TIMPs) are differentially expressed during excisional skin wound repair
26. Expression and localization of matrix metalloproteinase-12 in the aorta of cholesterol-fed rabbits; Relationship to lesion development
27. Localization of type I human skin collagenase in developing embryonic and fetal skin
28. Matrix metalloproteinases
29. Biological implications of macrophage infiltration in human tumor angiogenesis
30. Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)
31. Proteoglycans in health and disease; Structures and functions
32. Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonar hypertension as demonstrated by in situ hybridisation
33. Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines
34. Expression of human macrophage metalloelastase gene in hepatocellular carcinoma; Correlation with angiostatin generation and its clinical significance
35. Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing
36. Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds
37. Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma
38. Collagenase specificity in chondrosarcoma metastasis
39. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages
40. Metalloelastase is required for macrophage mediated proteolysis and matrix invasion in mice
41. Collagenase-3 (MMP-13) is expressed during human fetal ossification and reexpressed in postnatal bone remodeling and in rheumatoid arthritis
42. Establishment of a clonal chondrosarcoma cell line with cartilage phenotypes
43. Matrix metalloproteinase digestion of aggrecan in human cartilage tumours
44. Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor
45. Enhanced expression of human metalloelastase (MMP-12) in cutaneous granulomas and macrophage migration
46. Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations
47. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
48. Extracellular matrix remodeling during morphogenesis
49. Matrix-degrading proteases and angiogenesis during development and tumor formation
50. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I