Secretory, biosynthetic and cationic responses to 2-(N-phenyl-indoyl)imidazole in rat pancreatic islets

Pharmacological Research

Volumn 38, Issue 4, 1998, Pages 305-310

  Louchami, K ^a   Laghmich, A ^a   Jijakli, H ^a   Mest, H J ^b   Malaisse, W J ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

^b Lilly Research Laboratories   (Germany)

Author keywords

2 (N phenyl indoyl)imidazole; 86Rb and 45Ca fluxes; Insulin secretion; Pancreatic islets

Indexed keywords

2 (N PHENYLINDOYL)IMIDAZOLE; CALCIUM 45; CATION; GLUCOSE; IMIDAZOLE DERIVATIVE; INSULIN; PHENYLALANINE; RUBIDIUM 86; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; FEMALE; GLUCOSE METABOLISM; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PANCREAS SECRETION; PRIORITY JOURNAL; RAT;

EID: 0032190204     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1998.0367     Document Type: Article

References (15)

1. ATP channels and interaction with the exocytotic machinery. Diabetes 1996; 45: 1610-18.
2. 2+ mobilization from thapsigargin-sensitive stores in mouse pancreatic β-cells. Diabetes 1998; 47: 211-18.
3. 3. Malaisse-Lagae F, Malaisse WJ. Insulin release by pancreatic islets. In: Methods in Diabetes Research. Larner J, Pohl SL, eds. New York: John Wiley, 1984; I: 147-52.
4. 4. Herchuelz A, Malaisse WJ. Regulation of calcium fluxes in pancreatic islets: dissociation between calcium and insulin release. J Physiol Lond 1978; 283: 409-24.
5. 5. Jijakli H, Ulusoy S, Malaisse WJ. Dissociation between the potency and reversibility of the insulinotropic action of two meglitinide analogues. Pharmacol Res 1996; 34: 105-8.
6. 6. Malaisse WJ, Jijakli H, Ulusoy S, Cook L, Best L, Viñambres C, Villanueva-Peñacarrillo ML, Valverde I, Malaisse WJ. Insulinotropic action of methyl pyruvate: secretory, cationic, and biosynthetic aspects. Arch Biochem Biophys 1996; 335: 229-44.
7. 45calcium by isolated islets of Langerhans. Endocrinology 1997; 88: 72-80.
8. 86Rb outflow from pancreatic islets. I. Reciprocal changes in the response to glucose, tetraethylammonium and quinine. Mol Cell Endocrinol 1980; 17: 103-10.
9. 9. Malaisse WJ, Malaisse-Lagae F, King S. Effect of neutral red and imidazole upon insulin secretion. Diabetologia 1968; 4: 370-4.
10. 10. Lefèbvre P, Luyckx AS. Effect of imidazole and imidazole derivatives upon insulin secretion in the anaesthetized dog. Diabetologia 1970; 6: 636 (abstract).
11. 11. Malaisse WJ, Malaisse-Lagae F, Mayhew DA, Wright JP. Effects of sulfonylureas upon insulin secretion by rat's pancreas. In: Tolbutamide... after ten years. Butterfield WJM, Van Westering W, eds. Excerpta Medical Foundation, Amsterdam, 1967: 49-60.
12. 12. Malaisse WJ, Mahy M, Brisson GR, Malaisse-Lagae F. The stimulus-secretion coupling of glucose-induced insulin release. VIII. Combined effects of glucose and sulfonylureas. Eur J Clin Invest 1972; 2: 85-90.
13. 13. Herchuelz A, Malaisse WJ. Insulinotropic action of glipizide in vitro. Diabetologia 1973; 9: 309-10.
14. 14. Herchuelz A, Couturier E, Malaisse WJ. Regulation of calcium fluxes in pancreatic islets: glucose-induced calcium-calcium exchange. Am J Physiol 1980; 238: E96-103.
15. 15. Malaisse WJ. Insulin secretion: multifactorial regulation for a single process of release. Diabetologia 1973; 9: 167-73.