Effect of 17ß-estradiol or alendronate on the bone densitometry, bone histomorphometry and bone metabolism of ovariectomized rats

Brazilian Journal of Medical and Biological Research

Volumn 34, Issue 8, 2001, Pages 1015-1022

  Da Paz, L H B C ^a   De Falco, V ^a   Teng, N C ^a   Dos Reis, L M ^a   Pereira, R M R ^a   Jorgetti, V ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

17 Estradiol; Alendronate; Densitometry; Histomorphometry; Rat

Indexed keywords

ALENDRONIC ACID; DEOXYPYRIDINOLINE; ESTRADIOL; OSTEOCALCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; BONE ATROPHY; BONE DENSITY; BONE MASS; BONE METABOLISM; BONE MINERAL; BONE STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FEMALE; FEMUR; HISTOLOGY; NONHUMAN; OVARIECTOMY; RAT; TRABECULAR BONE; TREATMENT OUTCOME; ANIMAL; BONE; COMPARATIVE STUDY; DENSITOMETRY; DISEASE MODEL; OSTEOPOROSIS; WISTAR RAT;

ANIMALIA; RATTUS NORVEGICUS;

ALENDRONATE; ANIMALS; BONE AND BONES; BONE DENSITY; DENSITOMETRY; DISEASE MODELS, ANIMAL; ESTRADIOL; FEMALE; FEMUR; OSTEOPOROSIS; OVARIECTOMY; RATS; RATS, WISTAR;

EID: 0034741738     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2001000800007     Document Type: Article

References (39)

1. Lindsay R (1995). Estrogen deficiency. In: Riggs BL & Melton III LJ (Editors), Osteoporosis. Etiology, Diagnosis and Management Raven Press, New York.
2. Kanis JA, Gertz BJ, Singer F & Ortolani S (1995). Rationale for the use of alendronate in osteoporosis. Osteoporosis International, 5: 1-13.
3. Beek EV, Lowik C, Pluijm GDP & Papoulos S (1999). The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone. Explants in vitro: a clue to the mechanism of action of nitrogen-containing bisphosphonates. Journal of Bone and Mineral Research, 14: 722-729.
4. Colucci S, Minielli V, Zambonin G, Cirulli N, Mori G, Serra M, Patella V, Zallone AZ & Grano M (1998) Alendronate reduces adhesion of human osteoclast-like cells to bone and bone protein-coated surfaces. Calcified Tissue International, 63: 230-235.
5. Giuliani N, Pedrazzoni M, Passeri G & Girasole G (1998). Bisphosphonates Inhibit IL-6 production by human osteoblast-like cells. Scandinavian Journal of Rheumatology, 27: 38-41.
6. Ito M, Amizuka N, Nakajima T & Ozawa H (1999). Ultrastructural and cytochemical studies on cell death of osteoclasts induced by bisphosphonate treatment. Bone, 25: 447-452.
7. Nishikawa M, Akatsu T, Katayama Y, Yasutomo Y, Kado S, Kugai N, Yamamoto M & Nagata N (1996) Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures. Bone, 18: 9-14.
8. Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manologas SC & Bellido T (1995). Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. Journal of Clinical Investigation, 104: 1363-1374.
9. Rodan GA & Fleisch HÁ (1996). Bisphosphonates: Mechanisms of action. Journal of Clinical Investigation, 97: 2692-2696.
10. Sahni M, Guenther HL, Fleisch H, Collin P & Martin J (1993). Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. Journal of Clinical Investigation, 91: 2004-2011.
11. Sato M, Grasser W, Endo N, Akins R, Simmons H, Thompson DD, Golub E & Rodan GA (1991) Alendronate localization in rat bone and effects on osteoclast ultrastructure. Journal of Clinical Investigation, 88: 2095-2105.
12. Vitté C, Fleisch H & Guenther HL (1996). Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption. Endocrinology, 137: 2324-2333.
13. Miller SC & Bowman Jee WSS (1995). Available animal models of osteopenia-small and large Bone, 17 (Suppl 4): 117-123.
14. Mosekilde LI (1995). Assessing bone quality animal models in preclinical osteoporosis research. Bone, 17 (Suppl 4): 343-352.
15. Rodgers BJ, Faugere MCM & Malluche H (1993). Animal models for the study of bone loss after cessation of ovarian function. Bone, 14: 369-377.
16. Thompson DD, Simmons HA, Pirie CM & Ke HZ (1995). FDA guidelines and animal models for osteoporosis. Bone, 17 (Suppl 4): 125-133.
17. Mohamed S, Shapira D, Leichter I, Reznick A & Silbermann M (1998). Ability of different techniques of measuring bone loss in aging female rats. Calcified Tissue International, 42: 375-382.
18. Frost HM & Jee WSS (1991). On the rat model of human osteopenias and osteoporosis. Bone and Mineral, 18: 227-236.
19. Kalu DN (1991). The ovariectomized rat model of postmenopausal bone loss. Bone and Mineral, 15: 175-192.
20. Wronski TJ, Lowry PL, Walsh CC & Ignaszewski A (1985). Skeletal alterations in ovariectomized rats. Calcified Tissue International, 37: 324-328.
21. Yamazaki I & Yamaguchi H (1989). Characteristics of an ovariectomized osteopenic rat model. Journal of Bone and Mineral Research, 4: 13-22.
22. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJH, Ott SM & Recker RR (1987). Bone histomorphometry: Standardization of nomenclature, symbol, and units. Journal of Bone and Mineral Research, 2: 595-610.
23. Lane NE, Haupt D, Kimmel DB, Modin G & Kinney JH (1999). Early estrogen replacement therapy reverses the rapid loss of trabecular bone volume and prevents further deterioration of connectivity in the rat. Journal of Bone and Mineral Research, 14: 206-214
24. Pastoriau P, Chomel A & Bonnet J (1995). Specific evaluation of localized bone mass and bone loss in the rat using dual-energy absorptiometry subregional analysis. Osteoporosis International, 5: 143-149.
25. Cosman F, Schnitzer MB, McCann PD, Parisien MV, Dempster DW & Lindsay R (1992). Relationships between quantitative histological measurements and non-invasive assessments of bone mass. Bone, 13: 237-242.
26. Sato M, Bryant HU, Iversen P, Helterbrand J, Smietana F, Bemis K, Higgs R, Turner CH, Owan I, Takano Y & Burr DB (1996). Advantages of raloxifene over alendronate or estrogen on nonreproductive and reproductive tissues in the long-term dosing of ovanectomized rats. Journal of Pharmacology and Experimental Therapeutics, 279: 298-305.
27. Ammann P, Rizzolo R, Slosman D & Bonjour JP (1992). Sequencial and precise in vivo measurement of bone mineral density in rats using dual energy X-ray absorptiometry. Journal of Bone and Mineral Research, 7: 311-316.
28. Mitlak BH & Sato M (1997). Bone mineral measurements by DXA in animals. In: Arnett TR & Henderson B (Editors), Methods in Bone Biology. Chapman & Hall, London.
29. Griffin MG, Kimble R, Hopper W & Pacifici R (1993). Dual-energy X-ray absorptiometry of the rat: Accuracy, precision and measurement of bone loss. Journal of Bone and Mineral Research, 8: 795-800.
30. Rozemberg S, Vandromme J, Neve J, Aguilera A, Muregancuro A, Peretz A, Kinthaert J & Ham H (1995). Precision and accuracy of in vivo bone mineral measurement in rats using dual-energy X-ray absorptiometry. Osteoporosis International, 5: 47-53.
31. Yamaguchi H, Kushida K, Yamazaki K & Imove T (1995) Assessment of spine bone mineral density in ovariectomized rats using DXA. Journal of Bone and Mineral Research, 10: 1033-1039.
32. Seedor JG, Quarruccio HÁ & Thompson DD (1991). The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats. Journal of Bone and Mineral Research, 6: 339-346.
33. Belena R, Toolan BC, Shea M, Markatos A, Meyers ER, Lee SC, Opas EE, Seedor JG, Klein H, Frankenfield D, Quartuccio H, Floravanti C, Clair J, Brown E, Hayes WCM & Rodan GA (1993). The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. Journal of Clinical Investigation, 92: 2577-2586.
34. Kalu DN, Liu CC, Salermo E, Hollis B, Echon R & Ray M (1991). Skeletal response of ovariectomized rats to low and high doses of 17 ß-estradiol. Bone and Mineral, 14: 175-187.
35. Tobias JH & Compston JE (1999). Does estrogen stimulate osteoblast function in postmenopausal women? Bone, 24: 121-124.
36. Wronski TJ, Yen F & Scott KS (1991). Estrogen and diphosphonate treatment provides long-term protection against osteopenia in ovariectomized rats. Journal of Bone and Mineral Research, 6: 387-394.
37. Wronski TJ, Cintrón M, Doherty AL & Dann LM (1988). Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology, 123: 681-686.
38. Chavassieux PM, Arlot ME, Roux JP, Portero N, Daifotis A, Yates AJ, Hamdy NAT, Malice MP, Freedholm D & Meunier PJ (2000). Effects of alendronate on bone quality and remodeling in glucocorticoid-induced osteoporosis: A histomorphometric analysis of transiliac biopsies. Journal of Bone and Mineral Research, 15: 754-762.
39. Delmas PD, Schlemmer A, Gineyts E, Riis B & Christiansen C (1991). Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. Journal of Bone and Mineral Research, 6: 639-646.