Ultrastructural and cytochemical studies on cell death of osteoclasts induced by bisphosphonate treatment

Bone

Volumn 25, Issue 4, 1999, Pages 447-452

  Ito, M ^a,b   Amizuka, N ^b   Nakajima, T ^a   Ozawa, H ^b  

^a First Dept Oral Maxillofacial S   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bisphosphonate; Cell death; Macrophage; Osteoclast; Ultrastructure

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; DNA FRAGMENT; INCADRONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BLOOD VESSEL; CELL COUNT; CELL DEATH; CELL NUCLEUS; CELL STRUCTURE; CONTROLLED STUDY; CYTOCHEMISTRY; CYTOPLASM; ELECTRON MICROSCOPY; FEMUR; GOLGI COMPLEX; INTRAVENOUS DRUG ADMINISTRATION; MACROPHAGE; MALE; MICROSCOPY; NONHUMAN; OSTEOCLAST; TIBIA; ULTRASTRUCTURE;

ANIMALS; CELL DEATH; DIPHOSPHONATES; FEMUR; MALE; MICROSCOPY, ELECTRON; OSTEOCLASTS; RATS; TIBIA;

EID: 0032855763     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(99)00197-0     Document Type: Article

References (27)

1. Anderson C., Cape R.D.T., Crilly R.G., Hodsman A.B., Wolfe B.M.J. Preliminary observation of a form of coherence therapy for osteoporosis. Calcif Tissue Int. 36:1984;341-343.
2. Chambers T.J. Diphosphonates inhibit bone resorption by macrophages in vitro. J Pathol. 132:1980;255-262.
3. Compston J.E. The therapeutic use of bisphosphonates. Br Med J. 309:1994;711-715.
4. Dijkstra C.D., Jopp E.A., Joling P., Karaal G. The heterogeneity of mononuclear phagocytes in lymphoid organs distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3 . Immunology. 54:1985;598-599.
5. Ejiri S. The Preosteoclast and its cytodifferentiation into the osteoclast ultrastructural and histochemical studies of rat fetal parietal bone . Arch Histol Jpn. 46:1983;533-577.
6. Flanagan A.M., Chambers T.J. Dichloromethylenebisphosphonate (C12MBP) inhibits bone resorption through injury to osteoclasts that resorb C12MBP-coated bone. Bone Miner. 6:1989;33-43.
7. Flanagan A.M., Chambers T.J. Inhibition of bone resorption by bisphosphonate interactions between bisphosphonates, osteoclasts, and bone . Calcif Tissue Int. 49:1991;407-415.
8. Fleisch H. Diphosphonate history and mechanism of action . Metab Bone Dis Rel Res. 4-5:1981;279-288.
9. Fleisch H. Bisphosphonates pharmacology and use in the treatment of tumor-induced hypercalcemia and metastatic bone disease . Drugs. 42:1991;919-944.
10. Fleisch H. Bisphosphonates mechanisms of action . Endocrine Rev. 19:1998;80-100.
11. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific binding of nuclear DNA fragmentation. J Cell Biol. 119:1992;493-501.
12. Hughes D.E., Wright K.R., UY H.L., Sasaki A., Yoneda T., Roodman G.D., Mundy G.R., Boyce B.F. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res. 10:1995;1478-1487.
13. Hughes D.E., Mian M., Guilland-Cumming D.F., Russell R.G.G. The cellular mechanism of action of bisphosphonates. Drugs Exp Clin Res. 17:1991;109-114.
14. Kerr J.F.R., Wyllie A.H., Currie A.R. Apoptosis a basic biological phenomenon with wide-ranging implications in tissue kinetics . Br J Cancer. 26:1972;239-257.
15. Kessel R.G. The structure and function of annulate lamellae porous cytoplasmic and intranuclear membranes . Int Rev Cytol. 82:1983;181-303.
16. Lowik C.W.G.M., Van der Pluijm G., Van.der.Wee-Pals L.J.A., Bloys van treslong-de groot H., Bijvoet O.L.M. Migration and phenotype transformation of osteoclast precursors into mature osteoclasts the effect of a bisphosphonate . J Bone Miner Res. 3:1988;185-192.
17. Marshall M.J., Wilson A.S., Davie M.W.J. Effects of (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate on mouse osteoclasts. J Bone Miner Res. 5:1990;955-962.
18. Minkin C. Bone acid phosphatase tartrate-resistant acid phosphatase as a marker of osteoclast function . Calcif Tissue Int. 34:1982;285-290.
19. Nagao Y., Ishitobi Y., Kinoshita H., Fukushima S., Kawashima H. YM175, a new bisphosphonate, increases serum 1,25-dihydroxyvitamin D in rats via stimulating renal 1-hydroxylase activity. Biochem Biophys Res Commun. 180:1991;1172-1178.
20. Oberhammer F., Fritsch G., Schmied M., Pavelka M., Printz D., Purchio T., Lassmann H., Schulte-hermann R. Condensation of the chromatin at the membrane of an apoptotic nuclears is not associated with activation of an endonuclease. J Cell Sci. 104:1993;317-326.
21. Parfitt A.M., Mundy G.R., Roodman G.D., Hughes D.E., Boyce B.F. A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res. 11:1996;150-159.
22. Rodan G.A., Martin T.J. Role of osteoblasts in hormonal control of bone resorption a hypothesis . Calcif Tissue Int. 33:1981;349-351.
23. Sahni M., Guenther H.L., Fleisch H., Collin P., Martin T.J. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. J Clin Invest. 91:1993;2004-2011.
24. Sato M., Grasser W., Endo N., Akins R., Simmons H., Thompson D.D., Golub E., Rodan G.A. Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest. 88:1991;2095-2105.
25. Shinoda H., Adamek G., Felix R., Fleisch H., Schenk R., Hagan P. Structure-activity relationships of various bisphosphonates. Calcif Tissue Int. 35:1983;87-99.
26. Surh C.D., Sprent J. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature. 372:1994;100-103.
27. Takahashi N., Yamana H., Yoshiki S., Roodman G.D., Mundy G.R., Jones S.J., Suda T. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology. 122:1988;1373-1382.