Neuroprotective effects of the CRF1 antagonist R121920 after permanent focal ischemia in the rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 21, Issue 10, 2001, Pages 1208-1214

  Mackay, K B ^a   Bozigian, H ^a   Grigoriadis, D E ^a   Loddick, S A ^a   Verge, G ^a   Foster, A C ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

Cerebral ischemia; Corticotropin releasing factor; CRF1 antagonist; MCAO; Neuroprotection; R121920

Indexed keywords

7 (DIPROPYLAMINO) 2,5 DIMETHYL 3 [2 (DIMETHYLAMINO) 5 PYRIDYL]PYRAZOLO[1,5 A]PYRIMIDINE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; R 121920; UNCLASSIFIED DRUG; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CRF RECEPTOR TYPE 1; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG SELECTIVITY; MALE; MIDDLE CEREBRAL ARTERY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN EDEMA; DRUG ANTAGONISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN EDEMA; BRAIN ISCHEMIA; MALE; MIDDLE CEREBRAL ARTERY; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE;

EID: 0034740753     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200110000-00009     Document Type: Article

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