Physicochemical characterization of bisphosphonic carboxyfluorescein for osteotropic drug delivery

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 8, 1996, Pages 798-800

  Fujisaki, Jiro ^a   Tokunaga, Yuji ^a   Takahashi, Toshiya ^a   Murata, Saburo ^a   Shimojo, Fumio ^a   Hata, Takehisa ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; BISPHOSPHONIC CARBOXYFLUORESCEIN; BUFFER; CARBOXYFLUORESCEIN; HYDROXYAPATITE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG BINDING; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG HYDROLYSIS; DRUG TARGETING; PHYSICAL CHEMISTRY; SUSTAINED RELEASE PREPARATION;

EID: 0029812942     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb03976.x     Document Type: Article

References (6)

1. Eastoe, J. E. (1956) The organic matrix of bone. In: Bourne, G. H. (ed.) The Biochemistry and Physiology of Bone. Academic Press, New York, pp 81-105
2. Fleisch, H. (1988) Bisphosphonates: a new class of drugs in diseases of bone and calcium metabolism. In: Baker, P. F. (ed.) Handbook of Experimental Pharmacology, vol. 83, Springer, Berlin, pp 441-466
3. Fujisaki, J., Tokunaga, Y., Takahashi, T., Hirose, T., Shimojo, F., Kagayama, A., Hata, T. (1995) Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I: Synthesis and in vivo characterization of osteotropic carboxyfluorescein. J. Drug Targeting 3: 273-282
4. Jung, A., Bisaz, S., Fleisch, H. (1973) The binding of pyrophosphonate and two diphosphonates by hydroxyapatite crystals. Calcif. Tissue Res. 11: 269-280
5. Otsuka, M., Matsuda, Y., Suwa, Y., Fox, J., Higuchi, W. (1994) A Novel skeletal drug delivery system using self-setting calcium phosphate cement. 2. Physicochemical properties and drug release rate of the cement-containing indomethacin. J. Pharm. Sci. 83: 611-615
6. Ralston, E., Hjelmeland, L. M., Klausner, R. D., Weinstein, J. N., Blumenthal, R. (1981) Carboxyfluorescein as a probe for liposome-cell interactions: effect of impurities, and purification of the dye. Biochem. Biophys. Acta 649: 133-137