Treatment of mammalian cells with mimosine generates DNA breaks

Mutation Research - DNA Repair

Volumn 459, Issue 4, 2000, Pages 299-306

  Mikhailov, Ivailo ^a   Russev, George ^a   Anachkova, Boyka ^a  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Bulgaria)

Author keywords

Cell cycle; Comet assay; DNA synthesis; Mimosine; Nucleoid sedimentation

Indexed keywords

MIMOSINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; COMET ASSAY; CONTROLLED STUDY; DNA REPLICATION; DNA STRAND BREAKAGE; DNA SYNTHESIS; ERYTHROLEUKEMIA CELL; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CELL CYCLE; DNA; DNA DAMAGE; DNA, NEOPLASM; HUMANS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; LYMPHOCYTES; MICE; MIMOSINE; NUCLEIC ACID SYNTHESIS INHIBITORS; TUMOR CELLS, CULTURED;

EID: 0034738051     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(00)00007-0     Document Type: Article

References (34)

1. Lalande M. A reversible arrest point in the late G1 phase of the mammalian cell cycle. Exp. Cell Res. 186:1990;332-339.
2. Dijkwel P., Hamlin J. Initiation of DNA replication in the dihydrofolate reductase locus is confined to the early S-period in CHO cells synchronized with the plant amino acid mimosine. Mol. Cell. Biol. 12:1992;3715-3722.
3. Mosca P., Dijkwel P., Hamlin J. The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells. Mol. Cell. Biol. 12:1992;4375-4383.
4. Mosca P., Lin H.-B., Hamlin J. Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells. Nucl. Acids Res. 23:1995;261-268.
5. Lin H.-B., Falchetto R., Mosca P., Shabanowitz J., Hunts D., Hamlin J. Mimosine targets serine hydroxymethyltransferase. J. Biol. Chem. 271:1996;2548-2556.
6. Gilbert D., Neilson A., Miyazawa H., DePamphilis M., Burhans W. Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism. J. Biol. Chem. 270:1995;9597-9606.
7. Hughes T., Cook P. Mimosine arrests the cell cycle after cells enter S-phase. Exp. Cell Res. 222:1996;275-280.
8. Wang Y., Zhao J., Clapper J., Martin L.D., Du C., DeVore E.R., Harkins K., Dobbs D.L., Benbow R.M. Mimosine differentially inhibits DNA replication and cell cycle progression in somatic cells compared to embryonic cells of Xenopus laevis. Exp. Cell Res. 217:1995;84-91.
9. Kalejta R., Hamlin J. The dual effect of mimosine on DNA replication. Exp. Cell Res. 231:1997;173-183.
10. WAF1/CIP1SDI1 is elevated through a p53-independent pathway by mimosine. Cell Growth Differ. 7:1996;893-901.
11. Vogt G. In vivo decondensation of chromatin and nuclear fibrillar component by Leucaena leucocephala ingredient. Biol. Cell. 72:1991;211-215.
12. Vogt G., Bohm R., Segner H. Mimosine, a naturally occurring drug interfering primarily with the cell nucleus. J. Submicrosc. Cytol. Pathol. 25:1993;247-256.
13. Jha A.N., Hande P.M., Mullenders L.H.F., Natarajan A.T. Mimosine is a potent clastogen in primary and transformed hamster fibroblasts but not in primary and transformed human lymphocytes. Mutagenesis. 10:1995;385-391.
14. Tsvetkov L., Russev G., Anachkova B. Effect of mimosine on DNA synthesis in mammalian cells. Cancer Res. 57:1997;2252-2255.
15. Cook P.R., Brazel J.A. Supercoils in human DNA. J. Cell Sci. 19:1975;261-279.
16. Walicka M., Godlewska E. Radiation sensitivities are not related to the size of DNA supercoiled domains in L5178Y-R and L5178Y-S cells. Int. J. Radiat. Biol. 55:1989;953-961.
17. Olive P.L., Banath J.P., Fjell C.D. DNA strand breakage and DNA structure influence staining with propidium iodide using the alkaline comet assay. Cytometry. 16:1994;305-312.
18. Watson J., Erba E. Flow cytometry. Freshney R. Animal Cell Culture. 1992;165-213 IRL Press, Oxford.
19. Cook P.R., Brazel I. Detection and repair of single strand breaks in nuclear DNA. Nature. 263:1976;679-682.
20. Ostling O., Johanson K.J. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochim. Biophys. Res. Commun. 123:1984;291-298.
21. Fairbairn D.W., Olive P.L., O'Neill K.L. The comet assay: a comprehensive review. Mutat. Res. 339:1995;37-59.
22. Anderson D., Yu T.-W., McGregor D.B. Comet assay responses as indicators of carcinogen exposure. Mutagenesis. 13:1998;539-555.
23. Kunnev D., Tsvetkov L., Anachkova B., Russev G. Clusters of replicons that fire simultaneously may be organized into superloops. DNA Cell Biol. 16:1997;1059-1065.
24. Krude T. Mimosine arrests proliferating human cells before onset of DNA replication in a dose-dependent manner. Exp. Cell Res. 247:1999;148-159.
25. Ji O., Marnett L.J., Pietenpol J.A. Cell cycle re-entry following chemically induced synchronization leads to elevated p53 and p21 protein levels. Oncogene. 15:1997;2749-2753.
26. Yoshioka A., Tanaka S., Hiraoka O., Koyama Y., Hirota Y., Ayusawa D., Seno T., Garrett C., Wataya Y. Deoxyribonucleoside triphosphate imbalance. J. Biol. Chem. 262:1987;8235-8241.
27. Painter R.B., Young R.B. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl. Acad. Sci. U. S. A. 77:1980;7315-7317.
28. Painter R.B. Inhibition of mammalian cell DNA synthesis by ionizing radiation. Int. J. Radiat. Biol. 49:1986;771-781.
29. Lallev A., Anachkova B., Russev G. Effect of ionizing radiation and topoisomerase II inhibitors on DNA synthesis in mammalian cells. Eur. J. Biochem. 216:1993;177-181.
30. D'Anna J.A., Valdez J.G., Habbersett R.C., Crissman H.A. Association of G1/S-phase and late S-phase checkpoints with regulation of cyclin-dependent kinases in Chinese hamster ovary cells. Radiat. Res. 148:197;260-271.
31. Larner J.M., Lee H., Hamlin J.L.S. S phase damage sensing checkpoints in mammalian cells. Cancer Surv. 29:1997;25-45.
32. Bedford J.S. Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiation. Int. J. Radiat. Oncol., Biol., Phys. 21:1991;37-42.
33. McMillan T.J., Peacock J.K. Molecular determinants of radiosensitivity in mammalian cells. Int. J. Radiat. Biol. 65:1994;49-55.
34. Goodhead D.T. Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int. J. Radiat. Biol. 65:1994;7-17.