Il-8 single-chain homodimers and heterodimers: Interactions with the chemokine receptors CXCR1, CXCR2, and DARC

Protein Science

Volumn 6, Issue 3, 1997, Pages 609-617

  Leong, Steven R ^a   Lowman, Henry B ^a   Liu, Jun ^a   Shire, Steven ^a   Deforge, Laura E ^b   Gillece Castro, Beth L ^a   McDowell, Robert ^a   Hébert, Caroline A ^a  

^a GENENTECH INC   (United States)

^b Dept of BioAnalytical Technology ^*  (United States)

Author keywords

analytical ultracentrifugation; chemokine; dimerization; mutagenesis; neutrophil

Indexed keywords

CHEMOKINE RECEPTOR; INTERLEUKIN 8;

ARTICLE; BINDING AFFINITY; CROSS LINKING; DIMERIZATION; ENZYME ACTIVITY; MUTAGENESIS; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN ANALYSIS; ULTRACENTRIFUGATION;

EID: 0030932999     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560060310     Document Type: Article

References (38)

1. Baggiolini M, Dewald B, Moser B. 1994. Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines. Adv Immunol 55:97-179.
2. Baldwin ET, Weber IT, St Charles R, Xuan J -C, Appella E, Yamada M, Matsushima K, Edwards BFP, Clore GM, Gronenborn AM, Wlodawer A. 1991. Crystal structure of interleukin 8: Symbiosis of NMR and crystallography. Proc Natl Acad Sci USA 88:502-506.
3. Burrows SD, Doyle ML, Murphy KP, Franklin SG, White JR, Brooks I, McNulty DE, Scott MO, Knutson JR, Porter D, Young PR, Hensley P. 1994. Determination of the monomer-dimer equilibrium of interleukin-8 reveals it is a monomer at physiological concentrations. Biochemistry 33:12741-12745.
4. Chang CN, Rey M, Bochner B, Heyneker H, Gray G. 1987. High-level secretion of human growth hormone in Escherichia coli. Gene 55:189-196.
5. Clark-Lewis I, Dewald B, Loetscher M, Moser B, Baggiolini M. 1994. Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids. J Biol Chem 269:16075-16081.
6. Clark-Lewis I, Kim KS, Rajarathnam K, Gong JH, Dewald B, Moser B, Baggiolini M, Sykes BD. 1995. Structure-activity relationships of the chemokines. J Leukoc Biol 57:703-711.
7. Clore GM, Appella E, Yamada M, Matsushima K, Gronenbom AM. 1990. Three-dimensional structure of interleukin 8 in solution. Biochemistry 29:1689-1696.
8. Fairbrother WJ, Skelton NJ. 1996. Three-dimensional structures of the chemokine family. In: Horuk R, ed. Chemoattractant receptors and their ligands. Boca Raton, FL: CRC Press.
9. 15N relaxation measurements. J Mol Biol 230:364-372.
10. Hébert CA, Luscinskas FW, Kiely J-M, Luis EA, Darbonne WC, Bennett GL, Liu CC, Obin MS, Gimbrone MA Jr, Baker JB. 1990. Endothelial and leukocyte forms of IL-8. J Immunol 145:3033-3040.
11. Hébert CA, Vitangcol RV, Baker JB. 1991. Scanning mutagenesis of interleukin-8 identifies a cluster of residues important for receptor binding. J Biol Chem 266:18989-18994.
12. Hébert CA, Baker JB. 1993. Interleukin 8: A review.Cancer Invest 11:743-750.
13. Hesselgesser J, Chitnis CE, Miller LH, Yansura DG, Simmons LC, Fairbrother WJ, Kotts C, Wirth C, Gillece-Castro BL, Horuk R. 1995. A mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria. J Biol Chem 270:11472-11476.
14. Horuk R, Chitnis CE, Darbonne W, Colby T, Rybicki A, Hadley TJ, Miller LH. 1993. A receptor for the malarial parasite Plasmodium vivax: The erythrocyte chemokine receptor. Science 261:1182-1184.
15. Howard OMZ, Ben-Baruch A, Oppenheim JJ. 1996. Chemokines: Progress toward identifying molecular targets for therapeutic agents. Trends Biotechnol 14:46-51.
16. Huston JS, McCartney J, Tai MS, Mottola-Hartshorn C, Jin D, Warren F, Keck P, Oppermann H. 1993. Medical applications of single-chain antibodies. Int Rev Immunol 10:195-217.
17. Johnson ML, Correia JC, Yphantis DA, Halvorson HR. 1981. Analysis of data from the analytical ultracentrifuge by nonlinear least squares techniques. Biophys J 36:575-588.
18. Kunkel TA, Bebenek K, McClary J. 1991. Efficient site-directed mutagenesis using uracil-containing DNA. Methods Enzymol 204:125-139.
19. Lee J, Horuk R, Rice GC, Bennett GL, Camerato T, Wood WI. 1992. Characterization of two high affinity human interleukin-8 receptors. J Biol Chem 267:16283-16287.
20. Leong SR, Kabakoff RC, Hébert CA. 1994. Complete mutagenesis of the extracellular domain of interleukin-8 (IL-8) type A receptor identifies charged residues mediating IL-8 binding and signal transduction. J Biol Chem 269:19343-19348.
21. Lodi PJ, Garrett DS, Kuszewski J, Tsang ML, Weatherbee JA, Leonard WJ, Gronenborn AM, Clore GM. 1994. High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR. Science 263:1762-1767.
22. Lowman HB, Slagle PH, DeForge LE, Wirth CM, Gillece-Castro BL, Bourell JH, Fairbrother WJ. 1996. Exchanging interleukin-8 and melanoma growth-stimulating activity receptor binding specificities. J Biol Chem 271:14344-14352.
23. Lowman HB, Fairbrother WJ, Slagle PH, Kabakoff R, Liu J, Shire S, Hébert CA. 1997. Monomeric variants of IL-8: Effects of side chain substitutions and solution conditions upon dimer formation. Protein Sci 6:598-608.
24. 37 introduces CC chemokine activity into interleukin-8. J Biol Chem 270:2716-2721.
25. Lusti-Narasimhan M, Chollet A, Power CA, Allet B. Proudfoot AEI, Wells TNC. 1996. A molecular switch of chemokine receptor selectivity. J Biol Chem 271:3148-3153.
26. Munson PJ, Rodbard D. 1983. LIGAND: A computerized analysis of ligand binding data. Methods Enzymol 92:543-576.
27. Paolini JF, Willard D, Consler T, Luther M, Krangel MS. 1994. The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations. J Immunol 153:2704-2717.
28. Perisic O, Webb PA, Holliger P, Winter G, Williams RL. 1994. Crystal structure of a diabody, a bivalent antibody fragment. Structure 2:1217-1226.
29. Rajarathnam K, Sykes BD, Kay CM, Dewald B, Geiser T, Baggiolini M, Clark-Lewis I. 1994. Neutrophil activation by monomeric interleukin-8. Science 264:90-92.
30. 1H NMR solution structure of an active monomeric interleukin-8. Biochemistry 34:12983-12990.
31. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: A laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
32. Skelton NJ, Aspiras F, Ogez J, Schall TJ. 1995. Proton NMR assignments and solution conformation of RANTES, a chemokine of the C-C type. Biochemistry 34:5329-5342.
33. Tanaka Y, Adams DH, Hubscher S, Hirano H, Siebenlist U, Shaw S. 1993. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1 beta. Nature 361:79-82.
34. Webb LMC, Ehrengruber MU, Clark-Lewis I, Baggiolini M, Rot A. 1993. Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8. Proc Natl Acad Sci USA 90:7158-7162.
35. Weiner SJ, Kollman PA, Case DA, Singh UC, Ghio C, Alagona G, Profeta S Jr, Weiner P. 1984. A new force field for molecular mechanical simulation of nucleic acids and proteins. J Am Chem Soc 106:765-784.
36. Weiner SJ, Kollman PA, Nguyen DT, Case DA. 1986. An all-atom forcefield for simulations of proteins and nucleic acids. J Comp Chem 7:230-252.
37. Williams G, Borkakoti N, Bottomley GA, Cowan I, Fallowfield AG, Jones PS, Kirtland SJ, Price GJ, Price L. 1996. Mutagenesis studies of interleukin-8. J Biol Chem 271:9579-9586.
38. Zhang X, Chen L, Bancroft DP, Lai CK, Maione TE. 1994. Crystal structure of recombinant human platelet factor 4. Biochemistry 33:8361-8366.