Inflammatory mediators in bronchoalveolar lavage fluid and plasma in leukocytopenic patients with septic shock-induced acute respiratory distress syndrome

Critical Care Medicine

Volumn 26, Issue 7, 1998, Pages 1194-1199

  Kiehl, Michael G ^a,b   Ostermann, Helmut ^a   Thomas, Michael ^a   Müller, Carsten ^a   Cassens, Uwe ^a   Kienast, Joachim ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Haematology and Oncology   (Germany)

Author keywords

Acute respiratory distress syndrome; Bronchoalveolar lavage; Critical illness; Cytokines; Inflammatory mediators; Leukocytopenia; Septic shock

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CLINICAL ARTICLE; CRITICAL ILLNESS; DATA ANALYSIS; DISEASE SEVERITY; HUMAN; IMMUNE RESPONSE; INTENSIVE CARE; LEUKOPENIA; LUNG HEMODYNAMICS; LUNG INFILTRATE; LUNG LAVAGE; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPTIC SHOCK;

EID: 0031867468     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199807000-00019     Document Type: Article

References (40)

1. Fulkerson WJ, MacIntyre N, Stamler J, et al: Pathogenesis and treatment of the adult respiratory distress syndrome. Arch Intern Med 1996; 156:29-38
2. Goodman RB, Strieter RM, Martin DP, et al: Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am J Respir Crit Care Med 1996; 154: 602-611
3. Chollet Martin S, Montravers P, Gibert C, et al: High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. Infect Immun 1993; 61:4553-4559
4. Suter PM, Suter S, Girardin E, et al: High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am Rev Respir Dis 1992; 145:1016-1022
5. Donnelly SC, Strieter RM, Kunkel SL, et al: Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups. Lancet 1993; 341:643-647
6. Meduri GU, Headley S, Kohler G, et al: Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Chest 1995; 107:1062-1073
7. Grau GE, Mili N, Lou JN, et al: Phenotypic and functional analysis of pulmonary microvascular endothelial cells from patients with acute respiratory distress syndrome. Lab Invest 1996; 74:761-770
8. Miller EJ, Cohen AB, Nagao S, et al: Elevated levels of NAP-1/Interleukin-8 are present in the airspace of patients with the adult respiratory distress syndrome and are associated with increased mortality. Am Rev Respir Dis 1992; 146:427-432
9. Thijs LG, Hack CE: Time course of cytokine levels in sepsis. Intensive Care Med 1995; 21:8258-8263
10. Bellomo R: The cytokine network in the critically ill. Anaesth Intensive Care 1992; 20:288-302
11. Tracey KJ, Beutler B, Lowry SF, et al: Shock and tissue injury induced by recombinant human cachectin. Science 1986; 234:470-474
12. Marks JD, Marks CB, Luce JM, et al: Plasma tumor necrosis factor in patients with septic shock. Mortality rate, incidence of adult respiratory distress syndrome, and effects of methylprednisolone administration. Am Rev Respir Dis 1990; 141:94-97
13. Turnbull A, Goldiner P, Silverman D, et al: The role of an intensive care unit in a cancer center. Cancer 1976; 37: 82-84
14. Brunet F, Lanore JJ, Dhainaut JF, et al: Is intensive care justified for patients with haematological malignancies? Intensive Care Med 1990; 16: 291-297
15. Dellinger RP: Clinical trials in adult respiratory distress syndrome. New Horiz 1993; 1:584-592
16. Maschmeyer G, Link H, Hiddemann W, et al: Pulmonary infiltrations in febrile patients with neutropenia. Cancer 1994; 73:2296-2304
17. American College of Chest Physicians/ Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
18. Fanta CH, Pennington JE: Pneumonia in the immunocompromised host. In: Respiratory Infections. Third Edition. Pennington JE (Ed). New York, Raven Press, 1994, pp 275-294
19. Lengas A, Poletti V, Pacifico L, et al: Acute lung inflammation: Neutrophil elastase versus neutrophils in the bronchoalveolar lavage - Neutrophil elastase reflects better inflammatory intensity. Intensive Care Med 1994; 20:354-359
20. Annitage P, Berry G: Statistical methods in medical research. Oxford, England, Blackwell, 1987
21. Wallenstein S, Zucker C, Fleiss J: Some statistical methods useful in circulation research. Circ Res 1980; 47:1-9
22. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
23. Donnelly TJ, Meade P, Jagels M, et al: Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury. Crit Care Med 1994; 22:768-776
24. Meduri GU, Kohler G, Headley S, et al: Inflammatory cytokines in the BAL of patients with ARDS. Chest 1995; 108:1303-1314
25. Kollef MH, Silver P, Murphy DM, et al: The effect of late-onset ventilator-associated pneumonia in determining patient mortality. Chest 1995; 108: 1655-1662
26. Headley AS, Tolley E, Meduri GU: Infections and the inflammatory response in acute respiratory distress syndrome. Chest 1997; 111:1306-1321
27. Parsons PE, Moore FA, Moore EE, et al: Studies on the role of tumor necrosis factor in adult respiratory distress syndrome. Am Rev Respir Dis 1992; 146: 694-700
28. Shelhamer JH, Levine SJ, Wu T, et al: Airway inflammation. Ann Intern Med 1995; 123:288-304
29. Schönbohn H, Schuler M, Kolbe K, et al: Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-ra during febrile neutropenia: Results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia. Ann Hematol 1995; 71: 161-168
30. Waage A, Steinshamm S: Cytokine mediators of septic infections in the normal and the granulocytopenic host. Eur J Haematol 1997; 50:243-249
31. Steinmetz HT, Herbertz A, Bertram M, et al: Increase in interleukin-6 serum level preceding fever in granulocytopenia and correlation with death from sepsis. J Infect Dis 1995; 171:225-228
32. Ostermann H, Rothenburger M, Hesters RM, et al: Cytokine response to infection in patients with acute myelogenous leukaemia following intensive chemotherapy. Br J Haematol 1994; 88:332-337
33. Lamy M, Deby-Dupont G: Is sepsis a mediator-inhibitor mismatch? Intensive Care Med 1995; 21:S250-S257
34. Kiehl M, Ostermann H, Birkfellner T, et al: Inflammatory mediators in the bronchoalveolar lavage fluid in leukocytopenic patients with fever. Abstr. Am J Respir Crit Care Med 1996; 153:A616
35. Whiteside TL: Cytokine measurements and interpretation of cytokine assays in human disease. J Clin Immunol 1994; 14:327-339
36. Deitch EA: Cytokines yes, cytokines no, cytokines maybe? Crit Care Med 1993; 21:817-819
37. Balk RA: Septic shock: Pathophysiology. Curr Opin Anaesthesiol 1994; 7:136-140
38. Estopa R, Torres Marti A, Kastanos N, et al: Acute respiratory failure in severe hematologic disorders. Crit Care Med 1984; 12:26-28
39. Ognibene FP, Martin SE, Parker MM, et al: Adult respiratory distress syndrome in patients with severe neutropenia. N Engl J Med 1986; 315: 547-551
40. Lloyd-Thomas AR, Dhalinal HS, Lister TA, et al: Intensive therapy for life threatening medical complications of hematological malignancy. Intensive Care Med 1986; 12:317-324