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Volumn 118, Issue 21, 1996, Pages 5158-5159

Efficient synthesis of aromatic polyketides in vitro by the actinorhodin polyketide synthase

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CHEMISTRY; ENZYMES; SYNTHESIS (CHEMICAL);

EID: 15844385423     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja960479o     Document Type: Article
Times cited : (33)

References (31)
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    • For reviews, cf.: O'Hagan, D. Nat. Prod. Rep. 1995, 12, 1-32. Katz, L.; Donadio, S. Annu. Rev. Microbiol. 1993, 47, 875-912.
    • (1995) Nat. Prod. Rep. , vol.12 , pp. 1-32
    • O'Hagan, D.1
  • 2
    • 0027382486 scopus 로고
    • For reviews, cf.: O'Hagan, D. Nat. Prod. Rep. 1995, 12, 1-32. Katz, L.; Donadio, S. Annu. Rev. Microbiol. 1993, 47, 875-912.
    • (1993) Annu. Rev. Microbiol. , vol.47 , pp. 875-912
    • Katz, L.1    Donadio, S.2
  • 3
    • 0024449599 scopus 로고
    • Bibb, M. J.; Biró, S.; Motamedi, H.; Collins, J. F.; Hutchinson, C. R. EMBO J. 1989, 8, 2727-36. Sherman D. H.; Malpartida, F.; Bibb, Maureen; Kieser, H. M.; Bibb, Mervyn; Hopwood, D. A. EMBO J. 1989, 8 (9), 2717-25. Fernández-Moreno, M. A.; Martínez, E.; Boto, L.; Hopwood, D. A. Malpartida, F. J. Biol. Chem. 1992, 267, 19278-90.
    • (1989) EMBO J. , vol.8 , pp. 2727-2736
    • Bibb, M.J.1    Biró, S.2    Motamedi, H.3    Collins, J.F.4    Hutchinson, C.R.5
  • 4
    • 0024438917 scopus 로고
    • Bibb, M. J.; Biró, S.; Motamedi, H.; Collins, J. F.; Hutchinson, C. R. EMBO J. 1989, 8, 2727-36. Sherman D. H.; Malpartida, F.; Bibb, Maureen; Kieser, H. M.; Bibb, Mervyn; Hopwood, D. A. EMBO J. 1989, 8 (9), 2717-25. Fernández-Moreno, M. A.; Martínez, E.; Boto, L.; Hopwood, D. A. Malpartida, F. J. Biol. Chem. 1992, 267, 19278-90.
    • (1989) EMBO J. , vol.8 , Issue.9 , pp. 2717-2725
    • Sherman, D.H.1    Malpartida, F.2    Bibb, M.3    Kieser, H.M.4    Bibb, M.5    Hopwood, D.A.6
  • 5
    • 0026657813 scopus 로고
    • Bibb, M. J.; Biró, S.; Motamedi, H.; Collins, J. F.; Hutchinson, C. R. EMBO J. 1989, 8, 2727-36. Sherman D. H.; Malpartida, F.; Bibb, Maureen; Kieser, H. M.; Bibb, Mervyn; Hopwood, D. A. EMBO J. 1989, 8 (9), 2717-25. Fernández-Moreno, M. A.; Martínez, E.; Boto, L.; Hopwood, D. A. Malpartida, F. J. Biol. Chem. 1992, 267, 19278-90.
    • (1992) J. Biol. Chem. , vol.267 , pp. 19278-19290
    • Fernández-Moreno, M.A.1    Martínez, E.2    Boto, L.3    Hopwood, D.A.4    Malpartida, F.5
  • 20
    • 15844394280 scopus 로고    scopus 로고
    • note
    • f = 0.8).
  • 22
    • 0026546688 scopus 로고
    • Pig heart succinyl CoA transferase (Sigma) was used, see: Stern, J. R.; Coon M. J.; DelCampillo, A.; Schneider, M. C. J. Biol. Chem. 1956, 221, 15-31. Deana, R. Biochem. Intl. 1992, 26(4), 767-73.
    • (1992) Biochem. Intl. , vol.26 , Issue.4 , pp. 767-773
    • Deana, R.1
  • 23
    • 15844406820 scopus 로고    scopus 로고
    • note
    • 6 heptet at 39.5 ppm.
  • 24
    • 15844411681 scopus 로고    scopus 로고
    • note
    • 14C-containing HPLC fractions using Beckman LS3801 scintillation counter yielded comparable results.
  • 25
    • 0014939622 scopus 로고
    • Plate, C. A.; Joshi, V. C.; Wakil, S. J. J. Biol. Chem. 1970, 245, 2868-75. D'Agnolo, G.; Rosenfeld, I. S.; Awaya, J.; Omura, S.; Vagelos, P. R. Biochem. Biophys. Acta 1973, 326, 155-66.
    • (1970) J. Biol. Chem. , vol.245 , pp. 2868-2875
    • Plate, C.A.1    Joshi, V.C.2    Wakil, S.J.3
  • 28
    • 15844427070 scopus 로고    scopus 로고
    • note
    • However, we cannot exclude the possibility that this reaction is catalyzed by a different enzyme, distinct from the PKS.
  • 29
    • 15844426343 scopus 로고    scopus 로고
    • note
    • pSEK38 is an unpublished derivative of pRM21 (see ref 7) which includes the act KS/AT, CLF, ACP, ARO, and CYC; the CLF has an N-terminal fusion with the 8-residue FLAG peptide (Kodak/IBI). The polyketide products of S. coelicolor CH999/PSEK38 are qualitatively and quantitatively the same as those of S. coelicolor CH999/pRM21.
  • 31
    • 15844404365 scopus 로고    scopus 로고
    • note
    • In additon to tcmO, pZP4 contains genes for the complete tcm PKS and does not produce 3 or 4.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.