The single mutation Phe173 → Ala induces a molten globule-like state in murine interleukin-6

Biochemistry

Volumn 39, Issue 8, 2000, Pages 1942-1950

  Matthews, Jacqueline M ^a   Norton, Raymond S ^b   Hammacher, Annet ^a   Simpson, Richard J ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

8 ANILINO 1 NAPHTHALENESULFONIC ACID; ALANINE; GLOBULAR PROTEIN; PHENYLALANINE; RECOMBINANT INTERLEUKIN 6;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; LIGAND BINDING; MOUSE; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; RECEPTOR BINDING;

ALANINE; ANIMALS; CELL LINE; CIRCULAR DICHROISM; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-6; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MUTATION; PHENYLALANINE; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TEMPERATURE; TIME FACTORS; UREA;

ANIMALIA; MURINAE;

EID: 0034728379     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991973i     Document Type: Article

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