Stereospecific syntheses of trans-vinyldioxidosqualene and β- hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 1, 2000, Pages 223-232

  Viola, Franca ^a   Balliano, Gianni ^a   Milla, Paola ^a   Cattel, Luigi ^a   Rocco, Flavio ^a   Ceruti, Maurizio ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

2,3 oxidosqualene cyclase inhibitors; Enzyme inhibitors; Hypocholesterolemics; Trans vinyldioxidosqualene derivatives

Indexed keywords

LANOSTEROL SYNTHASE; SQUALENE DERIVATIVE; SULFIDE; VINYL DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CYCLIZATION; ENZYME INHIBITION; STEREOCHEMISTRY; SYNTHESIS;

ANIMALS; ENZYME INHIBITORS; INTRAMOLECULAR TRANSFERASES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER; SQUALENE; SWINE;

ANIMALIA; SUS SCROFA;

EID: 0034049063     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00286-2     Document Type: Article

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