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For leading references see: (a) Svensson, H. P.; Frank, I. S.; Berry, K. K.; Senter, P. D. J. Med. Chem. 1998, 41, 1507-1512 and references cited therein. (b) Bagshawe, K. D.; Begent, R. H. J. Adv. Drug Delivery Rev. 1996, 22, 365-367. (c) Bagshawe, K. D.; Sharma, S. K.; Springer, C. J.; Antoniw, P. Tumour Targeting 1995, 1, 17-29. (d) Rodrigues, M. L.; Carter, P.; Wirth, C.; Mullins, S.; Lee, A.; Blackburn, B. K. Chem. Biol. 1995, 2, 223-227. (e) See also www.seattlegenetics.com/.
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For leading references see: (a) Svensson, H. P.; Frank, I. S.; Berry, K. K.; Senter, P. D. J. Med. Chem. 1998, 41, 1507-1512 and references cited therein. (b) Bagshawe, K. D.; Begent, R. H. J. Adv. Drug Delivery Rev. 1996, 22, 365-367. (c) Bagshawe, K. D.; Sharma, S. K.; Springer, C. J.; Antoniw, P. Tumour Targeting 1995, 1, 17-29. (d) Rodrigues, M. L.; Carter, P.; Wirth, C.; Mullins, S.; Lee, A.; Blackburn, B. K. Chem. Biol. 1995, 2, 223-227. (e) See also www.seattlegenetics.com/.
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For leading references see: (a) Svensson, H. P.; Frank, I. S.; Berry, K. K.; Senter, P. D. J. Med. Chem. 1998, 41, 1507-1512 and references cited therein. (b) Bagshawe, K. D.; Begent, R. H. J. Adv. Drug Delivery Rev. 1996, 22, 365-367. (c) Bagshawe, K. D.; Sharma, S. K.; Springer, C. J.; Antoniw, P. Tumour Targeting 1995, 1, 17-29. (d) Rodrigues, M. L.; Carter, P.; Wirth, C.; Mullins, S.; Lee, A.; Blackburn, B. K. Chem. Biol. 1995, 2, 223-227. (e) See also www.seattlegenetics.com/.
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(e) See also
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For leading references see: (a) Svensson, H. P.; Frank, I. S.; Berry, K. K.; Senter, P. D. J. Med. Chem. 1998, 41, 1507-1512 and references cited therein. (b) Bagshawe, K. D.; Begent, R. H. J. Adv. Drug Delivery Rev. 1996, 22, 365-367. (c) Bagshawe, K. D.; Sharma, S. K.; Springer, C. J.; Antoniw, P. Tumour Targeting 1995, 1, 17-29. (d) Rodrigues, M. L.; Carter, P.; Wirth, C.; Mullins, S.; Lee, A.; Blackburn, B. K. Chem. Biol. 1995, 2, 223-227. (e) See also www.seattlegenetics.com/.
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37049088665
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This is a well established diagnostic pattern in β-lactam chemistry, see
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This is a well established diagnostic pattern in β-lactam chemistry, see: Davis, A. M.; Jones, M.; Page. M. I. J. Chem. Soc. Perkin Trans. 2, 1991, 1219-1223.
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85037934133
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The value of 4.0 Å is taken from the crystal structure data on the penicillin compound bearing the sulfenimine sidechain (RSN=) which was prepared by Gordon and co-workers; see Ref 8
-
The value of 4.0 Å is taken from the crystal structure data on the penicillin compound bearing the sulfenimine sidechain (RSN=) which was prepared by Gordon and co-workers; see Ref 8.
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37049112902
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(a) The reaction of piperidine-1-sulfenyl chloride with diamines to yield (cyclic) thiadiazoles provides a key intramolecular example
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(a) The reaction of piperidine-1-sulfenyl chloride with diamines to yield (cyclic) thiadiazoles provides a key intramolecular example: Bryce, M. R. J. Chem. Soc., Perkin Trans. 1 1984, 2591-2593.
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37049129409
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3) with primary and secondary amines is a relevant intermolecular example
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3) with primary and secondary amines is a relevant intermolecular example: Armitage, D. A.; Clark. M. J.; Kinsey, A. C. J. Chem. Soc. (C) 1971, 3867-3869.
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0003649925
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(c) See also Patai, S., Ed.; Wiley: Chichester Chapter 10.
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(c) See also: Capozzi, C.; Modena, G.; Pasquato, L. In The Chemistry of Sulphenic Acids and Derivatives; Patai, S., Ed.; Wiley: Chichester, 1990, Chapter 10. Hogg, D. R. In The Chemistry of Sulphenic Acids and Derivatives; Patai, S., Ed.; Wiley: Chichester, 1990, Chapter 9.
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Patai, S., Ed.; Wiley: Chichester Chapter 9
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(c) See also: Capozzi, C.; Modena, G.; Pasquato, L. In The Chemistry of Sulphenic Acids and Derivatives; Patai, S., Ed.; Wiley: Chichester, 1990, Chapter 10. Hogg, D. R. In The Chemistry of Sulphenic Acids and Derivatives; Patai, S., Ed.; Wiley: Chichester, 1990, Chapter 9.
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In the Chemistry of Sulphenic Acids and Derivatives
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Hogg, D.R.1
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31
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0012375760
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(a) Supporting evidence for the interconversion of Inter-A and Inter-B is provided by the observed ready contraction of seven- and eight-membered cyclic sulfides to form fused bicyclic structures by the nucleophilic addition of the sulfur atom to a carbonium ion center
-
(a) Supporting evidence for the interconversion of Inter-A and Inter-B is provided by the observed ready contraction of seven- and eight-membered cyclic sulfides to form fused bicyclic structures by the nucleophilic addition of the sulfur atom to a carbonium ion center: Cerè, V.; Peri, F.; Pollicino, S.; Antonio, A. J. Chem. Soc., Perkin Trans. 2 1998, 977-979. de Groot, A.; Boerma, J. A.; Wynberg, H. Tetrahedron Lett. 1968, 2365-2367.
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Cerè, V.1
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32
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0343262834
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-
(a) Supporting evidence for the interconversion of Inter-A and Inter-B is provided by the observed ready contraction of seven- and eight-membered cyclic sulfides to form fused bicyclic structures by the nucleophilic addition of the sulfur atom to a carbonium ion center: Cerè, V.; Peri, F.; Pollicino, S.; Antonio, A. J. Chem. Soc., Perkin Trans. 2 1998, 977-979. de Groot, A.; Boerma, J. A.; Wynberg, H. Tetrahedron Lett. 1968, 2365-2367.
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0003558195
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(b) For other examples of the transannular interaction of a sulfur atom with a carbonium ion center see
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(b) For other examples of the transannular interaction of a sulfur atom with a carbonium ion center see: Tabushi, I.; Tamaru, Y.; Yoshida, Z-I; Sugimoto, T. J. Am. Chem. Soc. 1975, 97, 2886-2891. Block, E. Reactions of Organosulfur Compounds; Academic Press: NY, 1978; Chapter 4.
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Academic Press: NY Chapter 4
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(b) For other examples of the transannular interaction of a sulfur atom with a carbonium ion center see: Tabushi, I.; Tamaru, Y.; Yoshida, Z-I; Sugimoto, T. J. Am. Chem. Soc. 1975, 97, 2886-2891. Block, E. Reactions of Organosulfur Compounds; Academic Press: NY, 1978; Chapter 4.
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Block, E.1
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35
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85037941673
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A certain degree of enzyme inhibition also occurred with 4bm, however, the partition number in favour of turnover versus inhibition was 15 000; see Ref. 7a
-
A certain degree of enzyme inhibition also occurred with 4bm, however, the partition number in favour of turnover versus inhibition was 15 000; see Ref. 7a.
-
-
-
-
36
-
-
0342380936
-
-
It is not clear that 6′ will be generated from 8′ (see below and also refer to Scheme 5) in aqueous buffer; it is probable that the end products result from further hydrolysis reactions of 8′. Products derived from reactions of sulfenic acids in aqueous solution are described in
-
It is not clear that 6′ will be generated from 8′ (see below and also refer to Scheme 5) in aqueous buffer; it is probable that the end products result from further hydrolysis reactions of 8′. Products derived from reactions of sulfenic acids in aqueous solution are described in: Hogg, D. R.; Vipond, P.W. Int. J. Sulfur Chem. C 1971, 6, 17-22.
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37
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85037947340
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-
3I with Proton Sponge
-
3I with Proton Sponge.
-
-
-
-
38
-
-
0029775843
-
-
Products derived from further hydrolytic reaction of an exo-methylene thiazine type structure, such as 16, are described in
-
Products derived from further hydrolytic reaction of an exo-methylene thiazine type structure, such as 16, are described in: Taibi-Tronche, P.; Massova, I.; Vakulenko, S. B.; Lerner, S. A.; Mobashery, S. J. Am. Chem. Soc. 1996, 118, 7441-7448.
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(b) For the seminal work on the classification of fully efficient enzymes see: Albery, W. J.; Knowles, J. R. Biochemistry 1976, 15, 5631-5640.
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