Mibefradil (Ro 40-5967) inhibits several Ca2+ and K+ currents in human fusion-competent myoblasts

British Journal of Pharmacology

Volumn 126, Issue 1, 1999, Pages 245-250

  Liu, Jian Hui ^a   Bijlenga, Philippe ^a   Occhiodoro, Teresa ^a   Fischer Lougheed, Jacqueline ^a   Bader, Charles R ^a   Bernheim, Laurent ^a,b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Mibefradil; Myoblast; Myoblast fusion; Potassium current

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; MIBEFRADIL; POTASSIUM ION;

ARTICLE; CALCIUM CURRENT; CELL FUSION; HUMAN; HUMAN CELL; MYOBLAST; POTASSIUM CURRENT; PRIORITY JOURNAL;

ADOLESCENT; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL FUSION; ELECTRIC STIMULATION; HUMANS; INFANT; MEMBRANE POTENTIALS; MIBEFRADIL; MUSCLE, SKELETAL; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; TETRAHYDRONAPHTHALENES;

EID: 0032919502     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702321     Document Type: Article

References (22)

1. BAROFFIO, A., AUBRY, J.P., KAELIN, A., KRAUSE, R.M., HAMANN, M. & BADER, C.R. (1993). Purification of human muscle satellite cells by flow cytometry. Muscle Nerve, 16, 498-505.
2. BAROFFIO, A., HAMANN, M., BERNHEIM, L., BOCHATON-PIALLAT, M.L., GABBIANI, G. & BADER, C.R. (1996). Identification of self-renewing myoblasts in the progeny of single human muscle satellite cells. Differentiation, 60, 47-57.
3. BERNHEIM, L., LIU, J.-H., HAMANN, M., HAENGGELI, C.A., F1SCHER-LOUGHEED, J. & BADER, C.R. (1996). Contribution of a non-inactivating potassium current to the resting potential of fusion-competent human myoblasts. J. Physiol., 493, 129- 141.
4. BIJLENGA, P., OCCHIODORO, T., LIU, J.-H., BADER, C.R., BERNHEIM, L. & FISCHER-LOUGHEED, J. (1998). An ether-ä-go-go K+ current h-eag, contributes to the hyperpolarization of human fusion-competent myoblasts. J. Physiol., 512, 317-323.
5. CLOZEL, J.P., ERTEL, E.A. & ERTEL, S.I. (1997). Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J. Hypertens. Suppl., 15, S17-S25.
6. CRIEES, L.L., LEE, J.H., YANG, J., SATIN, J., ZHANG, Y., DAUD, A-, BARCLAY, J., WILLIAMSON, M.P., FOX, M., REES, M. & PEREZREYES, E. (I998). Cloning and characterization of alphalH from human heart, a member of the T-type Ca2+ channel gene family. Circ.Res.,83, 103-109.
7. ERTEL, S.I. & ERTEL, E.A. (1997). Low-voltage-activated T-type Ca2+ channels. Treuils. Pharniacol. Sei., 18, 37-42.
8. HAM, R.G., STCLAIR, J.A., BLAU, U.M. & WEBSTER, C. (1989). Serum-free media for growth and differentiation of human muscle satellite cells. In Cellular and Molecular Biology of Muscle Development, Kedes, L.E & Stockdale, F.E., eds. New York: Liss, pp. 905-914.
9. HAMANN, M-, WIDMER, H., BAROFFIO, A., AUBRY, J.P., KRAUSE, R.M., KAELIN, A. & BADER, C.R. (1994). Sodium and potassium currents in freshly isolated and in proliferating human muscle satellite cells. J. Physiol., 475, 305-317.
10. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. ( 1981 ). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. Eur. J. Physiol., 391, 85-100.
11. KRAUSE, R.M., HAMANN, M., BADER, C.R., LIU, J.-H., BAROFFIO, A. & BERNHEIM, L. (1995). Activation of nicotinic acetylcholine receptors increases the rate of fusion of cultured human myoblasts. J. Physiol., 489, 779-790.
12. LIU, J.-H., BIJLENGA, P., FISCHER-LOUGHEED, J., OCCHIODORO, T., KAELIN, A., BADER, C.R. & BERNHEIM, L. (1998). Role of an inward rectifier K+ current and of hyperpolarization in human myoblast fusion. J. Physiol., 510, 467-476.
13. MISHRA, S.K. & HERMSMEYER, K. (1994). Selective inhibition of Ttype Ça2 channels by Ro 40-5967. Circ. Res., 75, 144-148.
14. NILIUS, B., PRENEN, J., KAMOUCHI, M., VIANA, F., VOETS, T. & DROOGMANS, G. (1997). Inhibition by mibefradil, a novel calcium channel antagonist, of Ca(2 + )- and volume-activated Cl~ channels in macrovascular endothelial cells. Br. J. Phannacol., 121, 547-555.
15. OCCHIODORO, T., BERNHEIM, L., LIU, J.-H., BIJLENGA, P., SINNREICH, M., BADER, C.R. & FISCHER-LOUGHEED, J. (1998). Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEES Lett., 434, 177-182.
16. PEREZ-REYES, E., CRIBBS, L.L., DAUD, A., LACERDA, A.E., BARCLAY, J., WILLIAMSON, M.P., FOX, M., REES, M. & LEE, J.H. (1998). Molecular characterization of a neuronal lowvoltage-activated T-type calcium channel. Nature, 391,896-900.
17. PO, A.L. & ZHANG, W.Y. (1998). What lessons can be learnt from withdrawal of mibefradil from the market? Lancet, 351, 18291830.
18. STCLAIR, J.A., MEYER, S., DEMAREST, S.D. & HAM, R.G. (1992). Improved medium with EGF and BSA for differentiated human skeletal muscle cells. Muscle Nerve, 15, 774-779.
19. VIANA, F., VAN DEN BOSCH, L., MISSIAEN, L., VANDENBERGHE, W., DROOGMANS, G., NILIUS, B. & ROBBERECHT, W. (1997). Mibefradil (Ro 40-5967) blocks multiple types of voltage-gated calcium channels in cultured rat spinal motoneurones. Cell Calcium, 22, 299-311.
20. VOETS, T., DROOGMANS, G. & NILIUS, B. (1996). Membrane currents and the resting membrane potential in cultured bovine pulmonary artery endothelial cells. J. Physiol., 497, 95-107.
21. WELLING, A., LACINOVA, L., DONATIN, K., LUDWIG, A., BOSSE, E., FLOCKERZI, V. & HOFMANN, F. (1995). Expression of the L-type calcium channel with two different beta subunits and its modulation by Ro 40-5967. Pflügers Arch., 429, 400-411.
22. WIDMER, H., HAMANN, M., BAROFFIO, A., BIJLENGA, P. & BADER, C.R. (1995). Voltage-dependent potassium current precedes fusion of human muscle satellite cells (Myoblasts). J. Cell. Physiol., 162, 52-63.