Regulation of Alzheimer β-amyloid precursor trafficking and metabolism

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1502, Issue 1, 2000, Pages 44-52

  Gandy, Sam ^a,b   Petanceska, Suzana ^a  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Alzheimer amyloid precursor; Metabolism; Regulation; Trafficking

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ESTRADIOL;

ALZHEIMER DISEASE; AMYLOIDOGENESIS; ESTROGEN THERAPY; HUMAN; HUMAN TISSUE; MUTATION; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOSIS; ANIMALS; BRAIN; CELL LINE; ESTRADIOL; GENE EXPRESSION REGULATION; HUMANS; PEPTIDE FRAGMENTS; SIGNAL TRANSDUCTION;

EID: 0034718231     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4439(00)00031-4     Document Type: Review

References (51)

1. Gandy S., Greengard P. Processing of Aβ-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease. Int. Rev. Neurobiol. 36:1994;29-50.
2. Gouras G.K., Xu H., Jovanovic J.N., Buxbaum J.D., Wang R., Greengard P., Relkin N.R., Gandy S. Generation and regulation of beta-amyloid peptide variants by neurons. J. Neurochem. 71:(5):1998;1920-1925.
3. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin L.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J.J., Wasco W., da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., St. George-Hyslop P.H. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
4. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:(8):1996;864-870.
5. Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., Prada C.M., Kim G., Seekins S., Yager D., Slunt H.H., Wang R., Seeger M., Levey A.I., Gandy S.E., Copeland N.G., Jenkins N.A., Price D.L., Younkin S.G., Sisodia S.S. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17:(5):1996;1005-1013.
6. Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y. Visualization of A beta 42 and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 12:(1):1994;45-53.
7. Lemere C.A., Blusztajn J.K., Yamaguchi H., Wisniewski T., Saido T.C., Selkoe D.J. Sequence of deposition of heterogeneous amyloid beta-peptides and APOE in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol. Dis. 3:(1):1996;16-32.
8. Calhoun M.E., Wiederhold K.H., Abramowski D., Phinney A.L., Probst A., Sturchler-Pierrat C., Staufenbiel M., Sommer B., Jucker M. Neuron loss in APP transgenic mice. Nature. 395:1998;755-756.
9. Buxbaum J.D., Gandy S.E., Cicchetti P., Ehrlich M.E., Czernik A.J., Fracasso R.P., Ramabhadran T.V., Unterbeck A.J., Greengard P. Processing of Alzheimer β/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc. Natl. Acad. Sci. USA. 87:1990;6003-6006.
10. Caporaso G.L., Gandy S.E., Buxbaum J.D., Ramabhadran T.V., Greengard P. Protein phosphorylation regulates secretion of Alzheimer β/A4 amyloid precursor protein. Proc. Natl. Acad. Sci. USA. 89:1992;3055-3059.
11. Gillespie S.L., Golde T.E., Younkin S.G. Secretory processing of the Alzheimer amyloid β/A4 protein precursor is increased by protein phosphorylation. Biochem. Biophys. Res. Commun. 187:1992;1285-1290.
12. Sinha S., Lieberburg I. Normal metabolism of the amyloid precursor protein (APP). Neurodegeneration. 1:1992;169-175.
13. Buxbaum J.D., Oishi M., Chen H.I., Pinkas-Kramarski R., Jaffe E.A., Gandy S.E., Greengard P. Cholinergic agonists and interleukin I regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA. 89:1992;10075-10078.
14. Nitsch R.M., Slack B.E., Wurtman R.J., Growdon J.H. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science. 258:1992;304-307.
15. Buxbaum J.D., Koo E.H., Greengard P. Protein phosphorylation inhibits production of Alzheimer amyloid β/A4 peptide. Proc. Natl. Acad. Sci. USA. 90:1993;9195-9198.
16. Hung A.Y., Haass C., Nitsch R.M., Qiu W.Q., Citron M., Wurtman R.J., Growdon J.H., Selkoe D.J. Activation of protein kinase C inhibits cellular production of the amyloid β-protein. J. Biol. Chem. 268:1993;22959-22962.
17. Savage M.J., Trusko S.P., Howland D.S., Pinsker L.R., Mistretta S., Reaume A.G., Greenberg N.D., Siman R., Scott R.W. Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester. J. Neurosci. 18:(5):1998;1743-1752.
18. Jaffe A.B., Toran-Allerand C.D., Greengard P., Gandy S.E. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. J. Biol. Chem. 269:(18):1994;13065-13068.
19. Xu H., Gouras G.K., Greenfield J.P., Vincent B., Naslund J., Mazzarelli L., Fried G., Javanovic J.N., Seeger M., Relkin N.R., Liao F., Checler F., Buxbaum J.D., Chait B.T., Thinakaran G., Sisodia S.S., Wang R., Greengard P., Gandy S. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat. Med. 4:(4):1998;447-451.
20. Chang D., Kwan J., Timiras P.S. Estrogens influence growth, maturation and amyloid beta-peptide production in neuroblastoma cells and in a beta-APP transfected kidney 293 cell line. Adv. Exp. Med. Biol. 429:1997;261-271.
21. Danenboerg H.D., Haring R., Fisher A., Pittel Z., Gurwitz D., Heldman E. Dehydroepiandrosterone (DHEA) increases production and release of Alzheimer's amyloid precursor protein. Life Sci. 59:(19):1996;1651-1657.
22. Danenberg H.D., Haring R., Heldman E., Gurwitz D., Ben-Nathan D., Pittel Z., Zuckerman A., Fisher A. Dehydroepiandrosterone augments M1-muscarinic receptor-stimulated amyloid precursor protein secretion in desensitized PC12M1 cells. Ann. N. Y. Acad. Sci. 774:1995;300-303.
23. Fisher A., Heldman E., Gurwitz D., Haring R., Karton Y., Meshulam H., Pittel Z., Marciano D., Brandeis R., Sadot E., Barg Y., Pinkas-Kramarski R., Vogel Z., Ginzburg I., Treves T.A., Verchovsky R., Klimowsky S., Korczyn A.D. M1 agonists for the treatment of Alzheimer's disease: novel therapeutic properties and clinical update. Ann. N. Y. Acad. Sci. 777:1996;189-196.
24. Haring R., Fisher A., Marciano D., Pittel Z., Kloog Y., Zuckerman A., Eshhar N., Heldman E., et al. Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to β-amyloid precursor protein secretion. J. Neurochem. 71:1998;2094-2103.
25. Roßner S., Ueberham U., Schliebs R., Perez-Polo J.R., Bigl V. p75 and trkA receptor signalling independently regulate amyloid precursor protein mRNA expression, isoform composition and protein secretion in PC12 cells. J. Neurochem. 71:1998;757-766.
26. Roßner S., Ueberham U., Schliebs R., Perez-Polo J.R., Bigl V. The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophic receptor signalling. Prog. Neurobiol. 56:1998;541-569.
27. da Cruz e Silva O., Iverfeldt K., Oltersdorf T., Sinha S., Lieberburg I., Ramabhadran T., Suzuki T., Sisodia S., Gandy S., Greenard P. Regulated cleavage of Alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail. Neuroscience. 57:1993;873-877.
28. Sahasrabudhe S.R., Spruyt M.A., Muenkel H.A., Blume A.J., Vitek M.P., Jacobsen J.S. Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells. J. Biol. Chem. 267:1992;25062-25608.
29. +2/calmodulin-dependent protein kinase II. Proc. Natl. Acad. Sci. USA. 85:1988;6218-6221.
30. Xu H., Greengard P., Gandy S. Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein. J. Biol. Chem. 270:(40):1995;23243-23245.
31. Caporaso G., Takei K., Gandy S., Matteoli M., Mundigl I., Greengard P., de Camilli P. Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer β/A4 amyloid precursor protein. J. Neurosci. 14:(5 Pt 2):1994;3122-3138.
32. Bosenberg M.W., Pandiella A., Massague J. Activated release of membrane-anchored TGF-α in the absence of cytosol. J. Cell Biol. 122:1993;95-101.
33. Black R.A., Rauch C.T., Kozlosky C.J., Peschon J.J., Slack J.L., Wolfson M.F., Castner B.J., Stocking K.L., Reddy P., Srinivasan S., Nelson N., Boiani N., Schooley K.A., Gerhart M., Davis R., Fitzner J.N., Johnson R.S., Paxton R.J., March C.J., Cerretti D.P. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 385:(6618):1997;729-733.
34. Peschon J.J., Slack J.L., Reddy P., Stocking K.L., Sunnarborg S.W., Lee D.C., Russell W.E., Castner B.J., Johnson R.S., Fitzner J.N., Boyce R.W., Nelson N., Kozlosky C.J., Wolfson M.D., Rauch C.T., Cerretti D.P., Paxton R.J., March C.J., Black R.A. An essential role for ectodomain shedding in mammalian development. Science. 282:(5392):1998;1281-1284.
35. Buxbaum J.D., Liu K.N., Luio Y., Slack J.L., Stocking K.L., Peschon J.J., Johnson R.S., Castner B.J., Cerretti D.P., Black R.A. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273:(43):1998;27765-27767.
36. Komano H.M., Seeger M., Gandy S., Wang G.T., Krafft G.A., Fuller R.S. Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast. J. Biol. Chem. 273:(48):1998;31648-31651.
37. Gandy S., Greengard P. Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities. Trends Pharmacol. Sci. 13:1992;108-113.
38. Wisniewski T., Frangione B. Apolipoprotein E: a pathological chaperone in patients with cerebral and systemic amyloid. Neurosci. Lett. 135:1992;235-238.
39. Bales K.R., Verina T., Dodel R.C., Du Y., Altstiel L., Bender M., Hyslop P., Johnstone E.M., Little S.P., Cummins D.J., Piccardo P., Ghetti B., Paul S.M. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat. Genet. 17:(3):1997;263-264.
40. Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Saivesen G.S., Roses A.D. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 90:1993;1977-1981.
41. Rebeck G.W., Reiter J.S., Strickland D.K., Hyman B.T. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron. 11:(4):1993;575-580.
42. D.S. Yang, D.H. Small, U. Seydel, J.D. Smith, J. Hallmayer, D. Strickland, S.E. Gandy, R.N. Martins, Apolipoprotein E promotes the association of amyloid-β with Chinese Hamster Ovary cells in an isoform-specific manner, Neuroscience (1999), in press.
43. Sun Y., Wu S., Bu G., Onifade M.K., Patel S.N., LaDu M.J., Fagan A.M., Holtzman D.M. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J. Neurosci. 18:(9):1998;3261-3272.
44. Masliah E., Terry R.D., Mallory M., Alford M., Hansen L.A. Diffuse plaques do not accentuate synapse loss in Alzheimer's disease. Am. J. Pathol. 137:1990;1293-1297.
45. Lue L.-F., Rogers J. Full complement activation fails in diffuse plaques of the Alzheimer's disease cerebellum. Dementia. 3:1992;308-313.
46. Luine V.N. Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats. Exp. Neurol. 89:(2):1985;484-490.
47. Sohrabji F., Greene L.A., Miranda R.C., Toran-Allerand C.D. Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells. J. Neurobiol. 25:(8):1994;974-988.
48. Stone D.J., Rozovsky I., Morgan T.E., Anderson C.P., Finch C.E. Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: implications for Alzheimer's disease. J. Neurosci. 18:(9):1998;3180-3185.
49. Gridley K.E., Green P.S., Simpkins J.W. A novel, synergistic interaction between 17β-estradiol and glutathione in the protection of neurons against Aβ 25-35-induced toxicity in vitro. Mol. Pharmacol. 4:(5):1998;874-880.
50. Yaffe K., Sawaya G., Lieberburg I., Grady D. Estrogen therapy in postmenopausal women. J. Am. Med. Assoc. 279:1998;688-695.
51. R. Mayeux, S. Gandy, Cognitive impairment, Alzheimer's disease and other dementias, in: M.B. Goldman, M.C. Hatch (Eds.), Women and Health, Academic Press, San Diego, CA, 2000.