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The RCM reaction of precursor 2a using methylene chloride at reflux gave the same result [45% (70%) after 7 days]. When toluene was tested as solvent the yield [17% (26%) after 2 days] was worse and extended decomposition was observed.
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See ref 2e for some recent, interesting results, regarding the influence of the absolute stereochemistry of the different hydroxyl protecting groups in sugar templates, on the course of RCM reactions.
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