Variability of transcriptional regulation after gene transfer with the retroviral tetracycline system

Journal of Biotechnology

Volumn 81, Issue 2-3, 2000, Pages 159-165

  Paulus, Werner ^a   Baur, Inge ^a   Keyvani, Kathy ^a   Senner, Volker ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Inducible expression; Position effects; Retroviral vectors; Tet system; Transcriptional regulation

Indexed keywords

CLONING;

RETROVIRAL TETRACYCLINE SYSTEM; TRANSCRIPTIONAL REGULATION;

GENE TRANSFER;

LUCIFERASE; TETRACYCLINE;

ARTICLE; CELL CLONE; EXPRESSION VECTOR; GENE ACTIVITY; GENE EXPRESSION SYSTEM; GENE REPRESSION; GENE TRANSFER; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RETROVIRUS; TRANSCRIPTION REGULATION; TRANSGENE;

ANIMALS; ANTI-BACTERIAL AGENTS; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; LUCIFERASES; RATS; RETROVIRIDAE; TETRACYCLINES; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; VIRUS INTEGRATION;

ANIMALIA; EUKARYOTA; UNIDENTIFIED RETROVIRUS;

EID: 0034714149     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(00)00291-1     Document Type: Article

References (30)

1. Ackland-Berglund C.E., Leib D.A. Efficacy of tetracycline-controlled gene expression is influenced by cell type. Biotechniques. 18:1995;196-200.
2. Chen J., Bezdek T., Chang J., Kherzai A.W., Willingham T., Azzara M., Nisen P.D. A glial-specific, repressible, adenovirus vector for brain tumor gene therapy. Cancer Res. 58:1998;3504-3507.
3. Clackson T. Regulated gene expression systems. Gene Ther. 7:2000;120-125.
4. Duch M., Paludan K., Lovmand J., Pedersen L., Jorgensen P., Pedersen F.S. A correlation between dexamethasone inducibility and basal expression levels of retroviral vector proviruses. Nucleic Acids Res. 21:1993;4777-4782.
5. Fukushige S., Sauer B. Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 89:1992;7905-7909.
6. Gossen M., Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U.S.A. 89:1992;5547-5551.
7. Gossen M., Freundlieb S., Bender G., Müller G., Hillen W., Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science. 268:1995;1766-1769.
8. Hoeben R.C., Migchielsen A.A., van der Jagt R.C., van Ormondt H., van der Eb A.J. Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position. J. Virol. 65:1991;904-912.
9. Howe J.R., Skryabin B.V., Belcher S.M., Zerillo C.A., Schmauss C. The responsiveness of a tetracycline-sensitive expression system differs in different cell lines. J. Biol. Chem. 270:1995;14168-14174.
10. Inoue T., Yamaza H., Sakai Y., Mizuno S., Ohno M., Hamasaki N., Fukumaki Y. Position-independent human β-globin gene expression mediated by a recombinant adeno-associated virus vector carrying the chicken β-globin insulator. J. Hum. Genet. 44:1999;152-162.
11. Jost M., Kari C., Rodeck U. An episomal vector for stable tetracycline-regulated gene expression. Nucleic Acids Res. 25:1997;3131-3134.
12. Katzman M., Katz R.A. Substrate recognition by retroviral integrases. Adv. Virus Res. 52:1999;371-395.
13. Kellum R., Schedl P. A position-effect assay for boundaries of higher order chromosomal domains. Cell. 64:1991;941-950.
14. Miller N., Whelan J. Progress in transcriptionally targeted and regulatable vectors for genetic therapy. Hum. Gene Ther. 8:1997;803-815.
15. Narumi K., Suzuki M., Song W., Moore M.A., Crystal R.G. Intermittent, repetitive orticosteroid-induced upregulation of platelet levels after adenovirus-mediated transfer to the liver of a chimeric glucocorticoid-responsive promoter controlling the thrombopoietin cDNA. Blood. 92:1998;822-833.
16. Oligino T., Poliani P.L., Wang Y., Tsai S.Y., O'Malley B.W., Fink D.J., Glorioso J.C. Drug inducible transgene expression in brain using a herpes simplex virus vector. Gene Ther. 5:1998;491-496.
17. Paulus W., Baur I., Boyce F.M., Breakefield X.O., Reeves S.A. Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells. J. Virol. 70:1996;62-67.
18. Pear W.S., Nolan G.P., Scott M.L., Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. U.S.A. 90:1993;8392-8396.
19. Pikaart M.J., Recillas-Targa F., Felsenfeld G. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev. 12:1998;2852-2862.
20. Recillas-Targa F., Bell A.C., Felsenfeld G. Positional enhancer-blocking activity of the chicken β-globin insulator in transiently transfected cells. Proc. Natl. Acad. Sci. U.S.A. 96:1999;14354-14359.
21. Rendahl K.G., Leff S.E., Otten G.R., Spratt S.K., Bohl D., Roey M.V., Donahue B.A., Cohen L.K., Mandel R.J., Danos O., Snyder R.O. Regulation of gene expression in vivo following transduction by two separate rAAV vectors. Nat. Biotechnol. 16:1998;757-761.
22. Rivella S., Sadelain M. Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing. Semin. Hematol. 35:1998;112-125.
23. Robbins P.B., Yu X.J., Skelton D.M., Pepper K.A., Wasserman R.M., Zhu L., Kohn D.B. Increased probability of expression from modified retroviral vectors in embryonal stem cells and embryonal carcinoma cells. J. Virol. 71:1997;9466-9474.
24. Saez E., No D., West A., Evans R.M. Inducible gene expression in mammalian cells and transgenic mice. Curr. Opin. Biotechnol. 8:1997;608-616.
25. Shih C.C., Stoye J.P., Coffin J.M. Highly preferred targets for retrovirus integration. Cell. 53:1988;531-537.
26. Watsuji T., Okamoto Y., Emi N., Katsuoka Y., Hagiwara M. Controlled gene expression with a reverse tetracycline-regulated retroviral vector (RTRV) system. Biochem. Biophys. Res. Commun. 234:1997;769-773.
27. Wilson C., Bellen H.J., Gehring W.J. Position effects on eukaryotic gene expression. Annu. Rev. Cell. Biol. 6:1990;679-714.
28. Withers-Ward E.S., Kitamura Y., Barnes J.P., Coffin J.M. Distribution of targets for avian retrovirus DNA integration in vivo. Genes Dev. 8:1994;1473-1487.
29. Yin D.X., Zhu L., Schimke R.T. Tetracycline-controlled gene expression system achieves high-level and quantitative control of gene expression. Anal. Biochem. 235:1996;195-201.
30. Zentilin L., Qin G., Tafuro S., Dinauer M.C., Baum C., Giacca M. Variegation of retroviral vector gene expression in myeloid cells. Gene Ther. 7:2000;153-166.