Guanosine 3',5'-cyclic monophosphate mediated inhibition of cell death induced by nerve growth factor withdrawal and β-amyloid: Protective effects of Propentofylline

Neuroscience

Volumn 99, Issue 4, 2000, Pages 737-750

  Wirtz Brugger, F ^a   Giovanni, A ^a  

^a SANOFI   (France)

Author keywords

Apoptosis; cGMP; Neurotoxicity; Nitric oxide; Phosphodiesterase inhibitor; Trophic factor deprivation

Indexed keywords

8 BROMO CYCLIC GMP; AMYLOID BETA PROTEIN; CASPASE 3; CYCLIC GMP; LACTATE DEHYDROGENASE; N ACETYL S NITROSOPENICILLAMINE; NERVE GROWTH FACTOR; PROPENTOFYLLINE;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOSE RESPONSE; DRUG EFFECT; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

1-METHYL-3-ISOBUTYLXANTHINE; 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; NERVE GROWTH FACTOR; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; NITRIC OXIDE DONORS; PC12 CELLS; PENICILLAMINE; PEPTIDE FRAGMENTS; PHOSPHODIESTERASE INHIBITORS; RATS; ROLIPRAM; XANTHINES;

EID: 0034706062     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00243-8     Document Type: Article

References (48)

1. Anderson A.J., Pike C.J., Cotman C.W. Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis. J. Neurochem. 65:1995;1498-1587.
2. Anderson A.J., Su J.H., Cotman C.W. DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J. Neurosci. 16:1996;1710-1719.
3. Barger S.W., Fiscus R.R., Ruth P., Hofmann F., Mattson M.P. Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor. J. Neurochem. 64:1995;2087-2096.
4. Barger S.W., Mattson M.P. Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor. Molec. Brain Res. 40:1996;116-126.
5. Batistatou A., Greene L.A. Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J. Cell Biol. 115:1991;461-471.
6. Behl C., Davis J.B., Klier F.G., Schubert D. Amyloid beta peptide induces necrosis rather than apoptosis. Brain Res. 645:1994;253-264.
7. Bredt D.S., Snyder S.H. Nitric oxide, a novel neuronal messenger. Neuron. 8:1992;3-11.
8. Butt E., van Bemmelen M., Fischer L., Walter U., Jastorff B. Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3′,5′-monophosphorothioates. Fedn Eur. biochem. Socs Lett. 263:1990;47-50.
9. Dawson V.L. Nitric oxide: role in neurotoxicity. Clin. exp. Pharm. Physiol. 22:1995;305-308.
10. Decker T., Lohmann-Matthes M.L. A quick and simple method for the quantification of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J. Immun. Meth. 15:1988;61-69.
11. DeLeo J., Toth L., Schubert P., Rudolphi K., Kreutzberg G.W. Ischemia-induced neuronal cell death, calcium accumulation, and glial response in the hippocampus of the Mongolian gerbil and protection by propentofylline (HWA 285). J. cerebr. Blood Flow Metab. 7:1987;745-751.
12. Dux E., Fastbom J., Ungerstedt U., Rudolphi K., Fredholm B.B. Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus. Brain Res. 516:1990;248-256.
13. Edwards S.N., Buckmaster A.E., Tolkovsky A.M. The death program in cultured sympathetic neurons can be suppressed at the posttranslational level by nerve growth factor, cyclic AMP, and depolarization. J. Neurochem. 57:1991;2140-2143.
14. Estevez A.G., Radi R., Barbeito L., Shin J.T., Thompson J.A., Beckman J.S. Peroxynitrite-induced cytotoxicity in PC12 cells: evidence for an apoptotic mechanism differentially modulated by neurotrophic factors. J. Neurochem. 65:1995;1543-1550.
15. Farinelli S.E., Park D.S., Greene L.A. Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism. J. Neurosci. 16:1996;2325-2334.
16. Furukawa K., Barger S.W., Blalock E.M., Mattson M.P. Activation of potassium channels and suppression of neuronal activity by secreted β-amyloid-precursor protein. Nature. 379:1996;74-78.
17. Gomez-Isla T., Price J.L., McKeel D.W.J., Morris J.C., Growdon J.H., Hyman B.T. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16:1996;4491-4500.
18. Greene L.A. Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J. Cell Biol. 78:1978;747-755.
19. Greene L.A., Tischler A.S. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. natn. Acad. Sci. USA. 73:1976;2424-2428.
20. Gschwind M., Huber G. Apoptotic cell death induced by beta-amyloid 1-42 peptide is cell type dependent. J. Neurochem. 65:1995;292-300.
21. Johnson M.P., McCarty D.R., Chmielewski P.A. Temporal dependent neuroprotection with propentofylline (HWA 285) in a temporary focal ischemia model. Eur. J. Pharmac. 346:1998;151-157.
22. Kim Y.M., Chung H.T., Kim S.S., Han J.A., Yoo Y.M., Kim K.M., Lee G.H., Yun H.Y., Grenn A., Li J.R., Simmons R.L., Billiar T.R. Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling. J. Neurosci. 19:1999;6740-6747.
23. Kittner B., Rossner M., Rother M. Clinical trials in dementia with propentofylline. Ann. N. Y. Acad. Sci. 826:1997;307-316.
24. Kuida K., Zheng T.S., Na S., Kuan C., Yang D., Karasuyama H., Rakic P., Flavell R.A. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 384:1996;368-372.
25. Li L., Prevette D., Oppenheim R.W., Milligan C.E. Involvement of specific caspases in motor neuron cell death in vivo and in vitro following trophic factor deprivation. Molec. cell. Neurosci. 12:1998;157-167.
26. Loo D.T., Copani A.G., Pike C.J., Whittemore E.R., Walencewicz A.J., Cotman C.W. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. natn. Acad. Sci. USA. 90:1993;7951-7955.
27. Mannick J.B., Asano K., Izumi K., Kieff E., Stamler J.S. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell. 79:1994;1137-1146.
28. Marcusson J., Rother M., Kittner B., Rossner M., Smith R.J., Babic T., Folnegovic-Smalc V., Moller H.J., Labs K.H. A 12-month, randomized, placebo-controlled trial of propentofylline (HWA 285) in patients with dementia according to DSM III-R. The European Propentofylline Study Group. Dement. Geriatr. Cogn. Disord. 8:1997;320-328.
29. Martin D.P., Schmidt R.E., DiStephano P.S., Lowry O.H., Carter J.G., Johnson E.M. Inhibitors of protein synthesis and RNA synthesis prevent neuronal cell death caused by nerve growth factor deprivation. J. Cell Biol. 106:1988;829-844.
30. Mattson M.P., Guo Z.H., Geiger J.D. Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism. J. Neurochem. 73:1999;532-537.
31. Meskini N., Nemoz G., Okyayuz-Baklouti I., Lagarde M., Prigent A. Phosphodiesterase inhibitory profile of some related Xanthine derivatives pharmacologically active on the peripheral microcirculation. Biochem. Pharmac. 47:1994;781-788.
32. Mielke R., Ghaemi M., Kessler J., Kittner B., Szelies B., Herholz K., Heiss W.D. Propentofylline enhances cerebral metabolic response to auditory memory stimulation in Alzheimer's disease. J. neurol. Sci. 154:1998;76-82.
33. Mielke R., Moller H.J., Erkinjuntti T., Rosenkranz B., Rother M., Kittner B. Propentofylline in the treatment of vascular dementia and Alzheimer-type dementia: overview of phase I and phase II clinical trials. Alzheimer Dis. Assoc. Disord. 12:(Suppl. 2):1998;S29-S35.
34. Murashima S., Tanaka T., Hockman S., Manganiello V. Characterization of particulate cyclic nucleotide phosphodiesterases from bovine brain: purification of a distinct cGMP-stimulated isoenzyme. Biochemistry. 29:1990;5285-5292.
35. Nagata K., Ogawa T., Omosu M., Fujimoto K., Hayashi S. In vitro and in vivo inhibitory effects of propentofylline on cyclic AMP phosphodiesterase activity. Arzneimittel-Forsch. 35:1985;1034-1036.
36. Nicholson D.W., Ali A., Thornberry N.A., Vaillancourt J.P., Ding C.K., Gallant M., Gareau Y., Griffin P.R., Labelle M., Lazebnik Y.A. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 376:1995;37-43.
37. Numagami Y., Marro P.J., Mishra O.P., Delivoria-Papadopoulos M. Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet. Neuroscience. 84:1998;1127-1133.
38. Paris D., Town T., Parker T.A., Tan J., Humphrey J., Crawford F., Mullan M. Inhibition of Alzheimer's β-Amyloid Induced Vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism. Expl Neurol. 157:1999;211-221.
39. Rukenstein A., Rydel R.E., Greene L.A. Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms. J. Neurosci. 11:1991;2552-2563.
40. Rydel R.E., Greene L.A. Cyclic-AMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor. Proc. natn. Acad Sci. USA. 85:1988;1257-1261.
41. Shearman M.S., Ragan C.I., Iversen L.L. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death. Proc. natn. Acad. Sci. USA. 91:1994;1470-1474.
42. Si Q.S., Nakamura Y., Kataoka K. Adenosine inhibits superoxide production in rat peritoneal macrophages via elevation of cAMP level. Immunopharmacology. 36:1997;1-7.
43. Sonnenburg W.K., Beavo J.A. Cyclic GMP and regulation of cyclic nucleotide hydrolysis. Adv. Pharmac. 26:1994;87-114.
44. Stamler J.S. Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell. 78:1994;931-936.
45. Stefanis L., Troy C.M., Qi H., Shelanski M.L., Greene L.A. Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity. J. Neurosci. 18:1998;9204-9215.
46. Watt J.A., Pike C.J., Walencewicz-Wasserman A.J., Cotman C.W. Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons. Brain Res. 661:1994;147-156.
47. Weldon D.T., Rogers S.D., Ghilardi J.R., Finke M.P., Cleary J.P., O'Hare E., Esler W.P., Maggio J.E., Mantyh P.W. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J. Neurosci. 18:1998;2161-2173.
48. Yamada K., Tanaka T., Senzaki K., Kameyama T., Nabeshima T. Propentofylline improves learning and memory deficits in rats induced by beta-amyloid protein (1-40). Eur. J. Pharmac. 349:1998;15-22.