Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet

Neuroscience

Volumn 84, Issue 4, 1998, Pages 1127-1133

  Numagami, Y ^a   Marro, P J ^b   Mishra, O P ^a   Delivoria Papadopoulos, M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MAINE MEDICAL CENTER   (United States)

Author keywords

Adenosine; Brain; Free radical; Hypoxia; Lipid peroxidation; Propentofylline

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; FREE RADICAL; PROPENTOFYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HYPOXIA; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; ELECTRON SPIN RESONANCE; HIGH ENERGY PHOSPHATE; HYPOTHESIS; LIPID PEROXIDATION; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; SPIN TRAPPING; SWINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; ANTI-ULCER AGENTS; BLOOD GAS ANALYSIS; BODY WEIGHT; FREE RADICALS; HYPOXIA, BRAIN; LIPID PEROXIDATION; PHOSPHOCREATINE; SWINE; XANTHINES;

EID: 0031972002     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00542-3     Document Type: Article

References (54)

1. 1. Andine P., Rudolphi K. A., Fredholm B. B. and Hagberg H. (1990) Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia. Br. J. Pharmac. 100, 814-818.
2. 2. Ballarin M., Fredholm B. B., Ambrosio S. and Mahy N. (1991) Extracellular levels of adenosine and its metabolites in the striatum of awake rats: inhibition of uptake and metabolism. Acta physiol. scand. 14, 103-297.
3. 3. Baum R. M. (1984) Superoxide theory of oxygen toxicity is center of heated debate. Chem. Eng. News 9 April, 20-28.
4. 4. Beckman J. S. (1991) The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J. dev. Physiol. 15, 53-59.
5. 5. Beckman J. S., Beckman T. W., Chen J., Marshall P. A. and Freeman B. A. (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. natn. Acad. Sci. U.S.A. 87, 1620-1624.
6. 6. Benveniste H., Drejer J., Schousboe A. and Diemer N. H. (1984) Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43, 1369-1374.
7. 7. Bredt D. S. and Snyder S. H. (1989) Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. natn. Acad. Sci. U.S.A. 86, 9030-9033.
8. 8. Buettner G. R. (1987) Spin trapping: ESR parameters of spin adducts. Free Radical Bio. Med. 3, 259-303.
9. 9. Burkey T. H. and Webster R. O. (1992) Adenosine inhibits fMLP-stimulated adherence and superoxide anion generation by human neutrophils at an early step in signal transduction. Biochim. biophys. Acta 1175, 312-318.
10. 10. Corradetti R., Lo Conte G., Moroni F., Passani M. B. and Pepeu G. (1984) Adenosine decreases aspartate and glutamate release from rat hippocampal slices. Eur. J. Pharmac. 104, 19-26.
11. 11. Cusack N. J. and Hourani S. M. O. (1981) 5́-N-Ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation. Br. J. Pharmac. 72, 443-447.
12. 12. Dunwiddie T. V. (1985) The physiological role of adenosine in the central nervous system. Int. Rev. Neurobiol. 27, 63-139.
13. 13. Fabian R. H., Dewitt D. S. and Kent T. A. (1995) In vivo detection of superoxide anion production by the brain using a cytochrome c electrode. J. cerebr. Blood Flow Metab. 15, 242-247.
14. 3H]glutamate release from rat hippocampal slices by L-phenylisopropyladenosine. Acta physiol. scand. 125, 121-123.
15. 15. Floyd R. A. (1990) Role of oxygen free radicals in carcinogenesis and brain ischemia. Fedn Am. Soc. exp. Biol. J. 4, 2587-2597.
16. 16. Folch J., Lees M. and Sloane-Stanley G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissue. J. biol. Chem. 226, 497-509.
17. 17. Forrester T., Harper A. M., MacKenzie E. T. and Thomson E. M. (1979) Effect of adenosine triphosphate and some derivatives on cerebral blood flow and metabolism. J. Physiol., Lond. 296, 343-355.
18. 18. Fredholm B. B., Lindstrom K. and Wallman-Johansson A. (1994) Propentofylline and other adenosine transport inhibitors increase the efflux of adenosine following electrical or metabolic stimulation of rat hippocampal slices. J. Neurochem. 62, 563-573.
19. 19. Fredholm B. B., Fastbom J., Kvanta A., Gerwins P. and Parkinson F. O. (1992) Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport. Fundam. clin. Pharmac. 6, 99-111.
20. 20. Fredholm B. B., Proctor W., Van der Ploeg I. and Dunwiddie T. V. (1989) In vivo pertussis toxin treatment attenuates some, but not all, adenosine A1 effects in slices of the rat hippocampus. Eur. J. Pharmac. 172, 249-262.
21. 21. Garthwaite J., Garthwaite G., Palmer R. M. and Moncada S. (1989) NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur. J. Pharmac. 172, 413-416.
22. 22. Geiger J. D. and Nagy J. I. (1987) Ontogenesis of adenosine deaminase activity in rat brain. J. Neurochem. 48, 147-153.
23. 23. Gidday J. M. and Park T. S. (1992) Effect of 2-chloroadenosine on cerebrovascular reactivity to hypercapnia in newborn pig. J. cerebr. Blood Flow Metab. 12, 656-663.
24. 24. Gidday J. M., Fitgittons J. E., Shah A. R., Kranjalis M. J. and Passe M. J. (1995) Reduction in cerebral ischemic injury in newborn rat by potentiation of endogenous adenosine. Ped. Res. 38, 306-311.
25. 25. Globus M. Y., Busto R., Dietrich W. D., Martinez E., Valdes I. and Ginsberg M. D. (1988) Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and gamma-aminobutyric acid studied by intracerebral microdialysis. J. Neurochem. 51, 1455-1464.
26. 26. Grome J. J. and Stefanovich V. (1985) Differential effects of xanthine derivatives on local cerebral blood flow and glucose utilization in the conscious rat. In Adenosine: Receptors and Modulation of Cell Function (eds Stefanovich V., Rudolphi K. A. and Schubert P.), pp. 453-457. IRL, Oxford, England.
27. 27. Halliwell B. (1992) Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
28. 2 use in fetal/neonatal sheep. J. appl. Physiol. 81, 541-547.
29. 29. Kuppusamy P., Ohnishi S. T., Numagami Y., Ohnishi T. and Zweier J. L. (1995) Three-dimensional imaging of nitric oxide production in the rat brain subjected to ischemia-hypoxia. J. cerebr. Blood Flow Metab. 15, 899-903.
30. 30. Lafon C. M., Pietri S., Culcasi M. and Bockaert J. (1993) NMDA-dependent superoxide production and neuro-toxicity. Nature 364, 535-537.
31. 31. Lamprecht W., Stein P., Eeinz F. and Weissner H. (1974) Creatine phosphate. In Methods of Enzymatic Analysis (ed. Bergmeyer H. U.), Vol. 4, pp. 1777-1781. Academic. New York.
32. 32. Lipton S. A. and Rosenberg P. A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. New Engl. J. Med. 330, 613-622.
33. 33. Mager R., Ferroni S. and Schubert P. (1990) Adenosine modulates a voltage-dependent chloride conductance in cultured hippocampal neurons. Brain Res. 532, 58-62.
34. 34. Mishra O. P., Wagerle L. C. and Delivoria-Papadopoulos M. (1988) 5′-Nucleotidase and adenosine deaminase in developing fetal guinea pig brain and the effect of maternal hypoxia. Neurochem. Res. 13, 1055-1060.
35. 35. Mishra O. P. and Delivoria-Papadopoulos M. (1989) Lipid peroxidation in developing fetal guinea pig brain during normoxia and hypoxia. Devl Brain Res. 45, 129-135.
36. 36. DiGiacomo J., Pané C., Gwiazdowski S., Mishra O. P. and Delivoria-Papadopoulos M. (1992) Effect of graded hypoxia on brain cell membrane injury in newborn piglets. Biol. Neonate 61, 25-32.
37. 37. Morgan P. F., Montgomery P. and Marangos P. J. (1987) Ontogenetic profile of the adenosine uptake sites in rat forebrain. J. Neurochem. 49, 852-855.
38. 38. Newby A. C. (1986) How does dipyridamole elevate extracellular adenosine concentration? Predictions from a three-compartment model of adenosine formation and inactivation. Biochem. J. 237, 841-845.
39. 39. Parkinson F. E., Rudolphi K. A. and Fredholm B. B. (1994) Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia. Gen. Pharmac. 25, 1053-1058.
40. 3H]adenosine influx. A study of three nucleoside transport systems. Biochem. Pharmac. 46, 891-896.
41. 41. Parkinson F. E. and Fredholm B. B. (1991) Effects of propentofylline on adenosine A1 and A2 receptors and nitrobenzylthioinosine-sensitive nucleoside transporters: quantitative autoradiographic analysis. Eur. J. Pharmac. 202, 361-366.
42. 42. Phillis J. W. and Wu P. H. (1981) The role of adenosine and its nucleotides in central synaptic transmission. Prog. Neurobiol. 16, 187-239.
43. 43. Radi R., Beckman J. S., Bush K M. and Freeman B. A. (1991) Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Archs Biochem. Biophys. 288, 481-487.
44. 44. Recknagel R. O. and Glende E. Jr (1984) Spectrophotometric detection of lipid conjugated dienes. Meth. Enzym, 105, 331-337.
45. 45. Richardson P. J. and Brown S. J. (1987) ATP release from affinity-purified rat cholinergic nerve terminals. J. Neurochem. 48, 622-630.
46. 46. Rudolphi K. A., Schubert P., Parkinson F. E. and Fredholm B. B. (1992) Adenosine and brain ischemia. Cerebrovasc. Brain Met. 4, 346-369.
47. 47. Rudolphi K. A., Schubert P., Parkinson F. E. and Fredholm B. B. (1992) Neuroprotective role of adenosine in cerebral ischaemia. Trends pharmac. Sci. 13, 439-445.
48. 48. Sawyer D. T. and Valentine J. S. (1981) How super is superoxide? Accounts chem. Res. 14, 393-400.
49. 2+ influx depends on endogenous adenosine. Int. J. Purine Pyrimid Res. 2, 11-16.
50. 50. Schubert P. (1988) Physiological modulation by adenosine: selective blockade of A1 receptors with DPCPX enhances stimulus train-evoked neuronal Ca influx in rat hippocampal slices. Brain Res. 458, 162-165.
51. 51. Shimizu H., Tanaka S. and Kodama T. (1972) Adenosine kinase of mammalian brain: partial purification and its role for the uptake of adenosine. J. Neurochem. 19, 687-698.
52. 52. Siggins G. R. and Schubert P. (1981) Adenosine depression of hippocampal neurons in vitro: an intracellular study of dose-dependent actions on synaptic and membrane potentials. Neurosci. Lett. 23, 55-60.
53. 53. Watson B. D. (1993) Evaluation of the concomitance of lipid peroxidation in experimental models of cerebral ischemia and stroke. Prog. Brain Res. 96, 69-95.
54. 54. Zetterstrom T., Vernet L., Ungerstedt U., Tossman U., Jonzon B. and Fredholm B. B. (1982) Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre. Neurosci. Lett. 29, 111-115.