Tachykinin NK1 and NK2 receptors mediate non-adrenergic non- cholinergic excitatory neuromuscular transmission in the human ileum

Neuropeptides

Volumn 31, Issue 3, 1997, Pages 265-271

  Zagorodnyuk, V ^a   Santicioli, P ^b   Turini, D ^c   Maggi, C A ^b  

^a BOGOMOLETZ INSTITUTE OF PHYSIOLOGY   (Ukraine)

^b Menarini Ricerche SpA   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APAMIN; ATROPINE; GUANETHIDINE; INDOMETACIN; TACHYKININ RECEPTOR; CYCLOPEPTIDE; DRUG DERIVATIVE; ENZYME INHIBITOR; MEN 10627; N(G) NITROARGININE; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; PEPTIDE FRAGMENT; PHYSALAEMIN; PHYSALAEMIN[9 DEXTRO PROLINE SPIRO GAMMA LACTAM 10 LEUCINE 11 TRYPTOPHAN]; SUBSTANCE P; SUBSTANCE P, SAR(9) MET(O2)(11); SUBSTANCE P, SAR(9)-MET(O2)(11)-;

ACTION POTENTIAL; ARTICLE; AUTORADIOGRAPHY; CELL MEMBRANE DEPOLARIZATION; EVOKED RESPONSE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; INTESTINE INNERVATION; NEUROMUSCULAR SYNAPSE; NEUROMUSCULAR TRANSMISSION; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; AGED; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ELECTROPHYSIOLOGY; ILEUM; INNERVATION; MIDDLE AGED; MUSCLE CONTRACTION; PHYSIOLOGY; SMOOTH MUSCLE; SYNAPTIC TRANSMISSION;

AGED; AGED, 80 AND OVER; APAMIN; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; HUMANS; ILEUM; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEUROMUSCULAR JUNCTION; NITROARGININE; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PHYSALAEMIN; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; SUBSTANCE P; SYNAPTIC TRANSMISSION;

EID: 0030612519     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0143-4179(97)90058-5     Document Type: Article

References (25)

1. Deacon C F, Agoston D V, Nau R, Conlon J M. Conversion of neuropeptide K to neurokinin A and vesicular colocalization of neurokinin A and substance P in neurons of the guinea-pig small intestine. J Neurochem 1987; 48: 141-146.
2. Sternini C, Anderson K, Frantz G, Krause J E, Brecha N. Expression of substance P/neurokinin A encoding preprotachykinin messenger ribonucleic acids in the rat enteric nervous system. Gastroenterology 1989; 97: 348-356.
3. Brookes S J H, Steele P A, Costa M. Identification and immunohistochemistry of cholinergic and noncholinergic circular muscle motor neurons in the guinea-pig small intestine. Neuroscience 1991; 42: 863-878.
4. Theodorsson E, Medfors B, Hellstrom P et al. Aspects on the role of tachykinins and VIP in control of secretion, motility and blood flow in the gut. Adv Exp Med Biol 1991; 298: 233-240.
5. Maggi C A, Patacchini R, Rovero P, Giachetti A. Tachykinin receptors and tachykinin receptor antagonists. J Autonom Pharmacol 1993; 13: 23-93.
6. 2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon. Neuroscience 1994; 63: 1137-1152.
7. 2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum. Br J Pharmacol 1995; 115: 337-346.
8. 2 receptors mediate noncholinergic excitatory junction potential in the circular muscle of guinea-pig colon. Br J Pharmacol 1993; 110: 795-803.
9. Maggi C A, Patacchini R, Santicioli P et al. Human isolated small intestine: motor responses of the longitudinal muscle to field stimulation and exogenous neuropeptides. Naunyn Schmiedebergs Arch Pharmacol 1989; 339: 415-423.
10. Maggi C A, Patacchini R, Santicioli P et al. Human isolated ileum: motor responses of the circular muscle to electrical field stimulation and exogenous neuropeptides. Naunyn Schmiedebergs Arch Pharmacol 1990; 341: 256-261.
11. Maggi C A, Giuliani S, Patacchini R et al. Tachykinin antagonists inhibit nerve-mediated contractions in the circular muscle of the human ileum. Gastroenterology 1992; 102: 88-96.
12. Gates T S, Zimmerman R P, Mantyh C R et al. Substance P and substance K receptor binding sites in the human gastrointestinal tract: localisation by autoradiography. Peptides 1989; 9: 1207-1219.
13. Llewellyn-Smith I J, Furness J B, Murphy R, O'Brien P E, Costa M. Substance P containing nerves in the human small intestine. Distribution, utrastructure and characterization of the immunoreactive peptide. Gastroenterology 1988; 95: 32-41.
14. Ferri G L, Adrian T E, Allen J M et al. Intramural distribution of regulatory peptides in the sigmoid-recto-anal region of the human gut. Gut 1988; 29:762-768.
15. Wattchow D A, Furness J B, Costa M. Distribution and coexistence of peptides in nerve fibres of the external muscle of human gastrointestinal tract. Gastroenterology 1988; 95: 32-41.
16. 2 receptors of the guinea-pig ileum and proximal colon. Br J Pharmacol 1994; 112: 150-160.
17. Maggi C A. The mammalian tachykinin receptors. Gen Pharmacol 1995; 26: 911-944.
18. Hagan R M, Ireland S J, Bailey F, McBride C, Jordan C A, Ward P. A spirolactam conformationally-constrained analogue of physalaemin which is a peptidase resistant, selective NK1 receptor agonist. Br J Pharmacol 1991; 102: 168P.
19. 2 receptors. J Pharmacol Exp Ther 1994; 271: 1489-1500.
20. Artemenko D P, Bury V A, Vladimirova I A, Shuba M F. Modification of the single sucrose-gap method. Physiol Zhurn 1982; 28: 374-380.
21. Hoyle C H V. A modified single sucrose gap - junction potentials and electrotonic potentials in gastrointestinal smooth muscle. J Pharmacol Methods 1987; 18: 219-226.
22. Zagorodnyuk V P, Vladimirova I A, Vovk E V, Shuba M F. Studies of the inhibitory non-adrenergic neuromuscular transmission in the smooth muscle of the normal human intestine and from a case of Hirschsprung's disease. J Autonom Nerv Syst 1989; 26: 51-60.
23. Regoli D, Drapeau G, Dion S, D'Orleans-Juste P. Pharmacological receptors for substance P and neurokinins. Life Sci 1987; 40: 109-117
24. Maggi C A, Giuliani S. Multiple inhibitory mechanisms mediate NANC relaxation in the circular muscle of the guinea-pig colon. Naunyn Schmiedebergs Arch Pharmacol 1993; 347: 630-634.
25. Boeckxstaens G E, Pelckmans P A, Herman A G, Van Maercke Y. Involvement of nitric oxide in the inhibitory innervation of the human isolated colon. Gastroenterology 1993; 104: 690-697.