Characterisation of central adenosine A1 receptors and adenosine transporters in mice lacking the adenosine A(2a) receptor

Brain Research

Volumn 877, Issue 2, 2000, Pages 160-169

  Snell, Broughton J ^a   Short, Jennifer L ^a   Drago, John ^b   Ledent, Catherine ^c   Lawrence, Andrew J ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Autonomic nervous system; In vitro autoradiography; Medullary nuclei; Pontine nuclei; Saturation binding; Up and down regulation

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; NITROBENZYLTHIOINOSINE;

ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; AUTORADIOGRAPHY; BEHAVIOR; CONTROLLED STUDY; INFERIOR OLIVE; LOCUS CERULEUS; MALE; MEDULLA OBLONGATA; MOUSE; NONHUMAN; PARABRACHIAL NUCLEUS; PRIORITY JOURNAL; PURINE METABOLISM; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SOLITARY TRACT NUCLEUS;

AFFINITY LABELS; ANIMAL; BINDING SITES; BRAIN; BRAIN CHEMISTRY; CARRIER PROTEINS; CELL MEMBRANE; GENOTYPE; MALE; MICE; MICE, KNOCKOUT; NEURONS; RADIOLIGAND ASSAY; RECEPTORS, PURINERGIC P1; SUPPORT, NON-U.S. GOV'T; THIOINOSINE; TRITIUM; XANTHINES;

EID: 0034703228     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02670-6     Document Type: Article

References (35)

1. Abdel-Rahman A.A., Tao S. Differential alteration of neuronal and cardiovascular responses to adenosine microinjected into the nucleus tractus solitarius of spontaneously hypertensive rats. Hypertension. 27:1996;939-948.
2. Aston-Jones G., Chiang C., Alexinsky T. Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. Prog. Brain Res. 88:1991;501-520.
3. Barraco R.A., El-Ridi M.R., Ergene E., Phillis J.W. Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns. Brain Res. Bull. 26:1991;59-84.
4. Barraco R.A., O'Leary D.S., Ergene E., Scislo T.J. Activation of purinergic receptor subtypes in the nucleus tractus solitarius elicits specific regional vascular response patterns. J. Autonom. Nerv. Syst. 59:1996;113-124.
5. Barraco R.A., Phillis J.W. Subtypes of adenosine receptors in the brainstem mediate opposite blood pressure responses. Neuropharmacology. 30:1991;403-407.
6. Borison H.L., Borison R., McCarthy L.E. Role of the area postrema in vomiting and related functions. Fedearion. Proc. 43:1984;2955-2958.
7. Castillo-Melendez M., Jarrott B., Lawrence A.J. Markers of adenosine removal in normotensive and hypertensive rat nervous tissue. Hypertension. 28:1996;1026-1033.
8. Castillo-Melendez M., Jarrott B., Lawrence A.J. Radioligand binding and autoradiographic visualisation of adenosine transport sites in human inferior vagal ganglia and their axonal transport along rat vagal afferent neurons. J. Autonom. Nerv. Syst. 57:1996;36-42.
9. 2a receptors on soma and central terminals of rat vagal afferent neurons. Brain Res. 652:1994;137-144.
10. 2a adenosine receptor deficiency attenuates brain injury induced by transient focal ischaemia in mice. J. Neurosci. 19:1999;9192-9200.
11. 2a receptors in the rat hippocampus. Brain Res. 649:1994;208-216.
12. Dampney R.A. Functional organization of central pathways regulating the cardiovascular system. Physiol. Rev. 74:1994;323-364.
13. 1 receptors modulate anxiety in CD1 mice. Psychopharmacology. 136:1998;311-319.
14. Franklin K.B.J., Paxinos G. The Mouse Brain in Stereotaxic Coordinates. 1997;Academic Press, San Diego.
15. 3H]NBTI in rat brain: An autoradiographic and membrane binding study. Brain. Res. Bull. 13:1984;657-666.
16. Hade J.S., Mifflin S.W., Donta T.S., Felder R.B. Stimulation of parabrachial neurons elicits a sympathetically mediated pressor response in cats. Am. J. Physiol. 255:1988;H1349-H1358.
17. 1AR mRNA expression or G protein alpha-subunit content. J. Neurochem. 71:1998;221-230.
18. Kell G.J., Delander G.E. Adenosine kinase and adenosine deaminase inhibition modulate spinal adenosine-and opioid agonist-induced antinociception in mice. Eur. J. Pharmacol. 271:1994;37-46.
19. 1 receptor binding in the dorsal vagal complex of hypertensive and normotensive rats. Brain Res. 802:1998;61-68.
20. 3H]adenosine transport in rat dorsal brain stem using a crude synaptosomal preparation. Neurochem. Int. 25:1994;221-226.
21. Lawrence A.J., Jarrott B. Neurochemical modulation of cardiovascular control in the nucleus tractus solitarius. Prog. Neurobiol. 48:1996;21-53.
22. 2a receptor. Nature. 388:1997;674-678.
23. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
24. G.A. McPherson, RADLIG, Elsevier Biosoft, Cambridge, 1994.
25. Mollace V., De Francesco E.A., Fersini G., Nistico G. Age-dependent changes in cardiovascular responses induced by muscimol infused into the nucleus tractus solitarii and nucleus parabrachialis medialis in rats. Brit. J. Pharmacol. 103:1991;1802-1806.
26. 2a receptors in the rat central nervous system. J. Comp. Neurol. 401:1998;163-186.
27. Shi D., Nikodijevic O., Jacobson K.A., Daly J.W. Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain. Cell. Mol. Neurobiol. 13:1993;247-261.
28. St Lambert J.H., Dashwood M.R., Thomas T., Spyer K.M. Medullary sites of action of adenosine in evoking cardiovascular responses in anaesthetised rat. J. Physiol. 479:1994;15P.
29. Strauss W.M. Southern blotting and hybridisation. Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., K S. Current Protocols in Molecular Biology. 1993;221-222 Wiley, New York.
30. Thomas T., Spyer K.M. The role of adenosine receptors in the rostral ventrolateral medulla in the cardiovascular response to defence area stimulation in the rat. Exp. Physiol. 81:1996;67-77.
31. Thorn J.A., Jarvis S.M. Adenosine transporters: Review. Gen. Pharmacol. 27:1996;613-620.
32. Tseng C.J., Ger L.P., Lin H.C., Tung C.S. Attenuated cardiovascular response to adenosine in the brain stem nuclei of spontaneously hypertensive rats. Hypertension. 25:1995;278-282.
33. Undesser K.P., Hasser E.M., Haywood J.R., Johnson A.K., Bishop V.S. Interactions of vasopressin with the area postrema in arterial baroreflex function in conscious rabbits. Circ. Res. 56:1985;410-417.
34. Van Bockstaele E.J., Peoples J., Telegan P. Efferent projections of the nucleus of the solitary tract to peri-locus coeruleus dendrites in rat brain: Evidence for a monosynaptic pathway. J. Comp. Neurol. 412:1999;410-428.
35. Yao S.T., Finkelstein D.I., Lawrence A.J. Nitrergic stimulation of the locus coeruleus modulates blood pressure and heart rate in the anaesthetized rat. Neuroscience. 91:1999;621-629.