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Volumn 33, Issue 17, 2000, Pages 6239-6248

Synthesis of norbornenyl polymers with bioactive oligopeptides by ring-opening metathesis polymerization

Author keywords

[No Author keywords available]

Indexed keywords

COMPOSITION EFFECTS; GLASS TRANSITION; INITIATORS (CHEMICAL); MOLECULAR STRUCTURE; MOLECULAR WEIGHT DISTRIBUTION; MONOMERS; OLIGOMERS; POLYPEPTIDES; RING OPENING POLYMERIZATION; RUTHENIUM; SYNTHESIS (CHEMICAL);

EID: 0034702667     PISSN: 00249297     EISSN: None     Source Type: Journal    
DOI: 10.1021/ma000460c     Document Type: Article
Times cited : (192)

References (35)
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    • For examples, see: (a) Manning, D. D.; Hu, X.; Beck, P.; Kiessling, L. L. J. Am. Chem. Soc. 1997, 119, 3161-3162. (b) Kanai, M.; Mortell, K. H.; Kiessling, L. L. J. Am. Chem. Soc. 1997, 119, 9931-9932 (c) Strong, L. E.; Kiessling, L. L. J. Am. Chem. Soc. 1999, 121, 6193-6196.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 9931-9932
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    • note
    • Deletion studies have determined that R is the important residue for PHSRN function, suggesting that this sequence could be further truncated to SRN, yet still retain its synergistic activity (see ref 5). Therefore, for simplicity, small peptides were chosen. However the polymers can be synthesized using the same approach with larger pendent peptides such as GRGDS and PHSRN.
  • 15
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    • and references therein
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    • Heated in 1,2-dichlorobenzene to 185°C, see: Craig, D. J. Am. Chem. Soc. 1951, 73, 4889-4892.
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  • 26
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    • note
    • Poly(15) and poly(16) have been synthesized by Baigini, et al. (ref 11a,b) using molybdenum catalysts; since ruthenium initiators were used in our study, the synthesis and characterization of these polymers using 1 as the initiator is included here.
  • 28
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    • note
    • This is thought to be due to unfavorable steric interactions between the monomer and initiating species; see ref 11b.
  • 29
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    • note
    • Catalyst 1 is markedly less active than 2 and 3 at higher temperatures and is less stable at higher temperatures (see ref 21). For this reason, polymerizations with 1 were conducted at room temperature, while those with 2 and 3 were conducted at 55°C.
  • 33
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    • note
    • This method could not be used with the other protected polymers due to the insolubility of these polymers in solvents suitable for centrifugation through the membrane.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.