In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in lacI transgenic (Big Blue®) mice

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 468, Issue 1, 2000, Pages 19-25

  Itoh, Toshiaki ^a   Suzuki, Takayoshi ^a   Nishikawa, Akiyoshi ^a   Furukawa, Fumio ^a   Takahashi, Michihito ^a   Xue, Wang ^a   Sofuni, Toshio ^a   Hayashi, Makoto ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

2 Amino 3,8 dimethylimidazo 4,5 f quinoxaline (MeIQx); Big Blue mouse; Cell proliferation; lacI; Micronucleus assay

Indexed keywords

2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; CYCLINE; HETEROCYCLIC AMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; GENE MUTATION; GENOTOXICITY; MICRONUCLEUS TEST; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ADMINISTRATION, ORAL; ANIMALS; BACTERIAL PROTEINS; CELL DIVISION; COLON; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI PROTEINS; FEMALE; INTUBATION, GASTROINTESTINAL; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS; MUTATION; QUINOXALINES; REPRESSOR PROTEINS; RETICULOCYTES; SEX FACTORS;

MUS MUSCULUS; RODENTIA; SALMONELLA;

EID: 0034702348     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00036-X     Document Type: Article

References (40)

1. Kasai H., Yamaizumi S., Wakabayashi K., Nagao M., Sugimura T., Yokoyama S., Miyazawa T., Spingarn N.E., Weisburger J.H., Nishimura S. Potent novel mutagens produced by boiling fish under normal conditions. Proc. Jpn. Acad., Ser. B. 56:1980;278-283.
2. Smith C., Payne V., Doolittle D.J., Debnath A.K., Lawlor T., Hansh C. Mutagenic activity of a series of synthetic and naturally occurring heterocyclic amines in Salmonella. Mutat. Res. 279:1992;61-73.
3. Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monogr. 56:1993.
4. Ohgaki H., Hasegawa H., Suenaga M., Sato S., Takayama S., Sugimura T. Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline from cooked foods. Carcinogenesis. 8:1987;665-668.
5. Kato T., Ohgaki H., Hasegawa H., Sato S., Takayama S., Sugimura T. Carcinogenicity in rats of mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Carcinogenesis. 9:1988;71-73.
6. Nakayasu M., Nakasato F., Sakamoto H., Terada M., Sugimura T. Mutagenic activity of heterocyclic amines in Chinese hamster lung cells with diphtheria toxin resistance as a marker. Mutat. Res. 118:1983;91-102.
7. Kerdar R.S., Dehner D., Wild D. Reactivity and genotoxicity of arylnitrenium ions in bacterial and mammalian cells. Toxicol. Lett. 67:1993;73-85.
8. Yoo M.A., Ryo H., Todo T., Kondo S. Mutagenic potency of heterocyclic amines in the Drosophila wing spot test and its correlation to carcinogenic potency. Jpn. J. Cancer Res. 76:1985;468-473.
9. Winton D.J., Gooderham N.J., Boobis A.R., Davies D.S., Ponder B.A.J. Mutagenesis of mouse intestine in vivo using the Dlb-1 specific locus test: studies with 1,2-dimethylhydrazine, dimethylnitrosamine, and the dietary mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Res. 50:1990;7992-7996.
10. Tucker J.D., Carrano A.V., Allen N.A., Christensen M.L., Knize M.G., Strout C.L., Felton J.S. In vivo cytogenetic effects of cooked food mutagens. Mutat. Res. 224:1989;105-113.
11. Loprieno N., Boncristiani G., Loprieno G. An experimental approach to identifying the genotoxic risk from cooked meat mutagens. Food Chem. Toxicol. 29:1991;377-386.
12. Breneman J.W., Briner J.F., Ramsey M.J., Director A., Tucker J.D. Cytogenetic results from a chronic feeding study of MeIQx in mice. Food Chem. Toxicol. 34:1996;717-724.
13. Gossen J.A., deLeeuw W.J.F., Tan C.H.T., Lohman P.H.M., Berends F., Knook D.L., Zwarthof E.C., Vijg J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying gene mutations in vivo. Proc. Natl. Acad. Sci. U. S. A. 86:1989;7971-7975.
14. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Sorge J.A., Short J.M. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 88:1991;7958-7962.
15. Gorelick N.J. Overview of mutation assays in transgenic mice for routine testing. Environ. Mol. Mutagen. 25:1995;218-230.
16. Heddle J.A. The use of transgenic animals in research. Environ. Mol. Mutagen. 32:1998;110-114.
17. Suzuki T., Hayashi M., Sofuni T., Myhr B.C. The concomitant detection of gene mutation and micronucleus induction by mitomycin C in vivo using lacZ transgenic mice. Mutat. Res. 285:1993;219-224.
18. Suzuki T., Hayashi M., Sofuni T. Initial experiences and future directions for transgenic mouse mutation assays. Mutat. Res. 307:1994;489-494.
19. Suzuki T., Itoh T., Hayashi M., Nishikawa A., Ikezaki S., Furukawa F., Takahashi M., Sofuni T. Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue mice. Environ. Mol. Mutagen. 28:1996;348-353.
20. Suzuki T., Hayashi M., Ochiai M., Wakabayashi K., Ushijima T., Sugimura T., Nagao M., Sofuni T. Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice. Mutat. Res. 369:1996;45-49.
21. Nishikawa A., Furukawa F., Imazawa T., Ikezaki S., Otoshi T., Fukushima S., Takahashi M. Cell proliferation in lung fibrosis-associated hyperplastic lesions. Hum. Exp. Toxicol. 14:1995;701-705.
22. Rogers B.J., Provost G.S., Young R.R., Putman D.L., Short J.M. Intralaboratory optimization and standardization of mutant screening conditions used for a lambda/lacI transgenic mouse mutagenesis assay (I). Mutat. Res. 327:1995;57-66.
23. Hayashi M., Morita T., Kodama Y., Sofuni T., Ishidate M. Jr. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res. 245:1990;245-249.
24. Director A.E., Nath J., Ramsey M.J., Swiger R.R., Tucker J.D. Cytogenetic analysis of mice chronically fed the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Mutat. Res. 359:1996;53-61.
25. Suzuki T., Hayashi M., Myhr B., Sofuni T. Diethylnitrosamine is mutagenic in liver but not in bone marrow of lacZ transgenic mice (Muta™Mouse). MMS Commun. 3:1995;33-39.
26. Davis C.D., Dacquel E.J., Schut H.A., Thorgeirsson S.S., Snyderwine E.G. In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice. Mutat. Res. 356:1996;287-296.
27. Zhang X.B., Felton J.S., Tucker J.D., Urlando C., Heddle J.A. Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and amino(α)carboline. Carcinogenesis. 17:1996;2259-2265.
28. Morrison V., Ashby J. A preliminary evaluation of performance of the Muta™Mouse (lacZ) and Big Blue™ (lacI) transgenic mouse mutation assays. Mutagenesis. 9:1994;367-375.
29. Gorelick N.J., Mirsalis J.C. A strategy for the application of transgenic rodent mutagenesis assays. Environ. Mol. Mutagen. 28:1996;434-442.
30. Frantz C.E., Bangerter C., Fultz E., Mayer K.M., Vogel J.S., Turteltaub K.W. Dose-response studies of MeIQx in rat liver and liver DNA at low doses. 16:1995;367-373.
31. Hirose M., Wakabayashi K., Ochiai M., Kushida H., Sato H., Sugimura T., Nagao M. Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Jpn. J. Cancer Res. 86:1995;516-522.
32. Schut H.A., Snyderwine E.G. DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis. Carcinogenesis. 20:1999;353-368.
33. Cosentino L., Heddle J.A. Effects of extended chronic exposures on endogenius and transgenic loci: implications for low dose extrapolations. Environ. Mol. Mutagen. 34:1999;208-215.
34. Okonogi H., Ushijima T., Shimizu H., Sugimura T., Nagao M. Induction of aberrant crypt foci in C57BL/6N mice by 2-amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Cancer Lett. 111:1997;105-109.
35. Okonogi H., Stuart G.R., Okochi E., Ushijima T., Sugimura T., Glickman B.W., Nagao M. Effect of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene. Mutat. Res. 395:1997;93-99.
36. Kleman M.I., Overvik E., Porsch-Hallstrom I., Blanck A., Gustafsson J.A. The heterocyclic amines IQ and MeIQx show no promotive effect in a short-term in vivo liver carcinogenesis assay. Carcinogenesis. 14:1993;2123-2125.
37. Nohmi T., Katoh M., Suzuki H., Matsui M., Yamada M., Watanabe M., Suzuki M., Horiya N., Ueda O., Shibuya T., Ikeda H., Sofuni T. A new transgenic mouse mutagenesis test system using Spi- and 6-thioguanine selections. Environ. Mol. Mutagen. 28:1996;465-470.
38. Jakubczak J.L., Merlino G., French J.E., Muller W.J., Paul B., Adhya S., Garges S. Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target. Proc. Natl. Acad. Sci. U. S. A. 93:1996;9073-9078.
39. Degawa M., Yamaya C., Hashimoto Y. Hepatic cytochrome P-450 isozyme(s) induced by dietary carcinogenic aromatic amines preferentially in female mice of DBA/2 and other strains. Carcinogenesis. 9:1988;567-571.
40. Tsuda H., Takahashi S., Yamaguchi S., Ozaki K., Ito N. Comparison of initiation potential of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in an in vivo carcinogen bioassay system. Carcinogenesis. 11:1990;549-552.