Cytogenetic analysis of mice chronically fed the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5 b]pyridine

Mutation Research - Environmental Mutagenesis and Related Subjects

Volumn 359, Issue 1, 1996, Pages 53-61

  Director, Alison E ^a   Nath, Joginder ^a   Ramsey, Marilyn J ^b   Swiger, Roy R ^b   Tucker, James D ^b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

2 Amino 1 methyl 6 phenylimidazo 4,5 b pyridine (PhIP); Cancer; Chromosome painting; Exchange; Heterocyclic amine; Micronucleus; Mouse; Sister chromatid

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; HETEROCYCLIC AMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; BONE MARROW; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME PAINTING; CHRONIC TOXICITY; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROCYTE; FEMALE; FOOD; GENOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE;

EID: 0030052806     PISSN: 01651161     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1161(96)90009-6     Document Type: Article

References (29)

1. Arvela, P., H. Kraul, F. Stenbäck and O. Pelkonen (1991) The cerium-induced liver injury and oxidative drug metabolism in DBA/2 and C57BL/6 mice, Toxicology, 69, 1-9.
2. Breneman, J.W., M.J. Ramsey, D.A. Lee, G.G. Eveleth. J.L. Minkler and J.D. Tucker (1993) The development of chromosome-specific DNA probes for the mouse and their application to chromosome painting, Chromosoma, 102, 591-598.
3. Breneman, J.W., R.R. Swiger, M.J. Ramsey, J.L. Minkler, G.G. Eveleth, R.A. Langlois and J.D. Tucker (1995) The development of painting probes for dual-color and multiple chromosome analysis in the mouse, Cytogenet. Cell Genet., 68, 197-202.
4. Buonarati, M.H., J.D. Tucker, J.L. Minkler, R.W. Wu, L.H. Thompson and J.S. Felton (1991) Metabolic activation and cytogenetic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Chinese hamster ovary cells expressing murine cytochrome P450 IA2, Mutagenesis, 6, 253-259.
5. Degawa, M., T. Hishinuma, H. Yoshida and Y. Hashimoto (1987) Species, sex, and organ differences in induction of a cytochrome P-450 isozyme responsible for carcinogen activation: effects of dietary hepatocarcinogenic tryptophan pyrolysate components in mice and rats, Carcinogenesis, 8, 1913-1918.
6. Director, A.E., J.W. Breneman, J.F. Briner, J. Nath, R.R. Swiger and J.D. Tucker (1994) The cytogenetic analysis of mice chronically fed PhIP or MeIQx, Environ. Mol. Mutagen., 23 (Suppl. 23), 13.
7. Dowdy, S. and S. Wearden (1991) Statistics for Research, 2nd edn., John Wiley & Sons, New York, pp. 193-218, 283-347, 554-580.
8. 1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, Jpn J. Cancer Res., 80, 1176-1178.
9. Felton, J.S., M.G. Knize, N.H. Shen, B.D. Andersen, L.F. Bjeldanes and F.T. Hatch (1986a) Identification of the mutagens in cooked beef, Environ. Health Perspect., 67, 17-24.
10. Felton, J.S., M.G. Knize, N.H. Shen, P.R. Lewis, B.D. Andersen, J. Happe and F.T. Hatch (1986b) The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), Carcinogenesis, 7, 1081-1086.
11. Hasegawa, R., M. Sano, S. Tamano, K. Imaida, T. Shirai, M. Nagao, T. Sugimura and N. Ito (1993) Dose dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenicity in rats, Carcinogenesis. 14, 2553-2557.
12. Hayashi, M., T. Sofuni and M. Ishidate Jr. (1983) An application of acridine orange fluorescent staining to the micronucleus test, Mutation Res., 120, 241-247.
13. Holme, J.A., H. Wallin, G. Brunborg, E.J. Søderlund, J.K. Hongslo and J. Alexander (1989) Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxyamino-PhIP, a directly acting genotoxic metabolite, Carcinogenesis, 10, 1289-1396.
14. Ito, N., R. Hasegawa, M. Sano, S. Tamano, H. Esumi, S. Takayama and T. Sugimura (1991) A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), Carcinogenesis, 12, 1503-1506.
15. 32 P-postlabelling studies on the DNA adducts of the food mutagens/carcinogens IQ and PhlP-adduct formation in a chemical system, and by rat and human metabolism. IARC Science Publications, 124, 173-179.
16. Knize, M.G. and J.S. Felton (1986) The synthesis of the cookedbeef mutagen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine and its 3-methyl isomer, Heterocycles, 24, 1815-1819.
17. Malfatti, M. (1995) Lawrence Livermore National Laboratory. Personal communication (unpublished data).
18. McManus, M.E.. J.S. Felton, M.G. Knize, W.M. Burgess. S. Roberts-Thomson, S.M. Pond, I. Stupens and M.E. Verunese (1989) Activation of the food derived mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by rabbit and human liver microsomes and purified forms of cytochrome P-450. Carcinogenesis, 10, 357-363.
19. Minchin, R.F., F.F. Kadlubar and K.F. Ilett (1993) Role of acetylation in colorectal cancer, Mutation Res., 290, 35-42.
20. Minkler, J., D. Stetka, Jr. and A.V. Carrano (1978) An ultraviolet light source for consistent differential staining of sister chromatids, Stain Tech., 53. 359-360.
21. Ochiai, M., K. Ogawa, K. Wakabayashi, T. Sugimura. S. Nagase. H. Esumi and M. Nagao (1991) Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminic rats, Jpn. J. Cancer Res., 82. 363-366.
22. Perry, P. and S. Wolff (1974) New Giemsa method for the differential staining of sister chromatids. Nature, 251, 156-158.
23. Probst, M.R., M. Blum, I. Fasshauer, D. D'Orazio. U.A. Meyer and D. Wild (1992) The role of the human acetylation polymorphism in the metabolic activity of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), Carcinogenesis, 13, 1713-1717.
24. Ramsey, M.J., J.D. Tucker, J.R. Senft, M. Nagao and R. Inoue (1995) The frequency of chromosome aberrations in lymphocytes in mice fed MeIQ as measured by chromosome painting. Environ. Mol. Mutagen., 25 (Suppl. 25), 44.
25. Spruill, M.D., M.J. Ramsey, R.R. Swiger, J. Nath and J.D. Tucker (1995) The analysis of stable radiation-induced translocations in mice using chromosome painting, Environ. Mol. Mutagen., 25 (Suppl. 25), 50.
26. Sugimura, T., M. Nagao, T. Kawachi, M. Honda. T. Yahagi, Y. Seino, S. Sato, N. Matsukura, T. Matsusima, A. Shirai. M. Sawamura and H. Matsumoto (1977) Mutagens-carcinogens in food, with special reference to highly mutagenic pyrolytic products in broiled foods, in: H.H. Hiat, J.D. Watson and J.A. Winston (Eds.), Origins of Human Cancer, Book C, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 1561-1576.
27. Thompson, L.H., J.D. Tucker, S.A. Stewart, M.L. Christensen, E.P. Salazar, A.V. Carrano and J.S. Felton (1987) Genotoxicity of compounds from cooked beef in repair deficient CHO cells versus Salmonella mutagenicity, Mutagenesis, 2, 483-487.
28. Tucker, J.D., A.V. Carrano, N.A. Allen, M.L. Christensen, M.G. Knize, C.L. Strout and J.S. Felton (1989) In vivo cytogenetic effects of cooked food mutagens, Mutation Res., 224, 105-113.
29. Tucker, J.D., A. Auletta, M.C. Cimino, K.L. Dearfield, D. Jacobsonkram, R.R. Tice and A.V. Carrano (1993) Sister-chromatid exchange - 2nd report of the Gene-Tox program, Mutation Res., 297, 101-180.