Expanded expression of heme oxygenase-1 (HO-1) in the hypothalamic median eminence of aged as compared with young rats: An immunocytochemical study

Neuroscience Letters

Volumn 271, Issue 2, 1999, Pages 113-116

  Iijima, Norio ^a   Tamada, Yoshitaka ^a   Hayashi, Seiji ^a   Tanaka, Masaki ^a   Ishihara, Akihiko ^b   Hasegawa, Michinori ^c   Ibata, Yasuhiko ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Fuso Pharmaceutical Industries Ltd   (Japan)

Author keywords

Aging; Heme oxygenase 1; Median eminence; Rat brain

Indexed keywords

HEME OXYGENASE;

ADOLESCENT; AGE; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ELECTRON MICROSCOPY; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MEDIAN EMINENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AGING; ANIMALS; FLUORESCENT ANTIBODY TECHNIQUE; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; MEDIAN EMINENCE; MICROSCOPY, ELECTRON; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033588214     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00543-1     Document Type: Article

References (20)

1. Applegate L., Luscher P., Tyrrel R. Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells. Cancer Res. 51:1991;974-978.
2. Chauvet N., Privat A., Alonso G. Aged median eminence glial cell cultures promote survival and neurite outgrowth of cocultured neurons. Glia. 18:1996;211-223.
3. Dennery P.A., Sridhar K.J., Lee C.S., Wong H.E., Shokoohi V., Rodgers P.A., Spitz D.R. Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts. J. Biol. Chem. 272:1997;14937-14942.
4. Dwyer B.E., Nishimura R.N., Vellis J. Heme oxygenase is a heat shock protein and PEST protein in rat astroglial cells. Glia. 5:1995;300-305.
5. Dwyer B.E., Nishimura R.N., Lu S-Y. Differential expression of heme oxygenase-1 in cultured cortical neurons and astrocytes determined by the aid of a new heme oxygenase antibody. Response to oxidative stress. Mol. Brain Res. 30:1995;37-47.
6. Ewing J.F., Haber S.N., Maines M.D. Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: hyperthermia causes rapid induction of mRNA and protein. J. Neuroendocri. 58:1992;1140-1149.
7. Ewing J.F., Maines M.D. Rapid induction of heme oxygenase-1 mRNA and protein by hyperthermia in rat brain: heme oxygenase2 is not a heat shock protein. Proc. Natl. Acad. Sci. USA. 88:1991;5364-5368.
8. Ewing J.F., Maines M.D. In situ hybridization and immunohistochemical localization of heme-oxyganase-2 mRNA and protein in normal rat brain: differential distribution of isozyme1 and 2. Mol. Cell Neurosci. 3:1992;559-570.
9. Friebe A., Schultz G., Koesling D. Sensitizing soluble guanylyl cyclase to become a high CO-sensitive enzyme. EMBO J. 1996;15.
10. Fukuda K., Richmon J.D., Sato M., Sharp F.R., Panter S.S., Noble L.J. Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury. Brain Res. 736:1996;68-75.
11. Kharitonov V.G., Sharma V.S., Pilz R.B., Magde D., Koesling D. Basis of guanylate cyclase activation by carbon monoxide. Proc. Natl. Acad. Sci. USA. 92:1995;2568-2571.
12. Lamar C.A., Mahesh V.B., Brann D.W. Regulation of gonadotropin-releasing hormone (GnRH) secretion by heme molecules: a regulatory role for carbon monoxide. Endocrinology. 137:1996;790-793.
13. Matuoka Y., Kitamura Y., Ozaki M., Kakinuma J., Tooyama I., Kimura H., Taniguchi T. Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience. 85:1998;1223-1233.
14. Maines M.D., Trakshel G.M., Kutty R.K. Characterization of two constitutive forms of rat liver microsomal heme oxygenase: only one molecular species of the enzyme is inducible. J. Biol. Chem. 265:1986;411-419.
15. Pozzoli G., Mancuso C., Mirtella A., Preziosi P., Grossman A.B., Navarra P. Carbon monoxide as a novel neuroendocrine modulator: inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants. Endocrinology. 135:1994;2314-2317.
16. Synder, S.H., Jaffrey, S.R., Zakhary, R., Nitric oxide and carbon monoxide: parallel roles as neural messengers. Brain Res. Rev., 1997.
17. Verma A., Hirsh D.J., Glatt C.E., Ronnett G.V., Snynder S.H. Carbon monoxide: a putative neural messenger. Science. 259:1993;381-384.
18. Vincent S.R., Das S., Maines M.D. Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons. Neuroscience. 63:1994;223-231.
19. Zakhary R., Gaine S.P., Dinerman J.L., Ruat M., Flavahan N.A., Synder S.H. Heme oxygenase2: endothelial and neuronal localization and roles in endothelium-dependent relaxation. Proc. Natl. Acad. Sci. USA. 93:1996;795-798.
20. Zakhary R., Poss K.D., Jaffrey S.R., Ferris C.D., Tonegawa S., Snyder S.H. Targeted gene deletion of heme oxygenase2 reveals neural role for carbon monooxide. Proc. Natl. Acad. Sci. USA. 94:1997;14848-14853.