2,7-Dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine as a new template for the design of CCK2 receptor antagonists

Journal of Medicinal Chemistry

Volumn 43, Issue 19, 2000, Pages 3518-3529

  McDonald, I M ^a   Dunstone, D J ^a   Kalindjian, S B ^a   Linney, I D ^a   Low, C M R ^a   Pether, M J ^a   Steel, K I M ^a   Tozer, M J ^a   Vinter, J G ^a  

^a James Black Foundation   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; 2,7 DIOXO 2,3,4,5,6,7 HEXAHYDRO 1H BENZO[H][1,4]DIAZONINE; 4 [[2 [2 [[(2 ADAMANTYLOXY)CARBONYL]AMINO] 3 (1H INDOL 3 YL) 2 METHYLPROPIONAMIDO] 1 PHENYLETHYL]AMINO] 4 OXOBUTYRIC ACID MEGLUMINE; 4 ACETYL 3 (1 ADAMANTYL) METHYL 1 (2 CHLOROBENZYL) 5 CARBOXYMETHYLAMINOCARBONYL 2,7 DIOXO 2,3,4,5,6,7 HEXAHYDRO 1H BENZO[H][1,4]DIAZONINE; 5 [[[[[(3,5 DICARBOXYPHENYL)AMINO]CARBONYL] 2 PHNEYLETHYL]AMINO]CARBONYL] 6 [[(1 ADAMANTYLMETHYL)AMINO]CARBONYL]INDOLE; 6 [[(1 ADAMANTYLMETHYL)AMINO]CARBONYL] 5 [[1 [[(3,5 DICARBOXYPHENYL)AMINO]CARBONYL] 2 PHENYLETHYLAMINO]CARBONYL]INDOLE; ASPERLICIN; BENZODIAZEPINE DERIVATIVE; CHOLECYSTOKININ; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; PENTAGASTRIN; TRYPTOLINE; UNCLASSIFIED DRUG;

ACID SECRETION; ARTICLE; CHOLECYSTOKININ BLOOD LEVEL; DRUG CONFORMATION; DRUG DESIGN; GASTRIN BLOOD LEVEL; GUINEA PIG; LIGAND BINDING; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ANIMALS; BINDING, COMPETITIVE; DRUG DESIGN; GASTRIC ACID; GUINEA PIGS; MODELS, MOLECULAR; PANCREAS; QUINONES; RADIOLIGAND ASSAY; RATS; RECEPTORS, CHOLECYSTOKININ; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034699373     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000960w     Document Type: Article

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