1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT(2C) receptor inverse agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 16, 2000, Pages 1867-1870

  Bromidge, Steven M ^a   Davies, Susannah ^a   Duckworth, D Malcolm ^a   Forbes, Ian T ^a   Jones, Graham E ^a   Jones, Jerome ^a   King, Frank D ^a   Blackburn, Thomas P ^a   Holland, Vicky ^a   Kennett, Guy A ^a   Lightowler, Sean ^a   Middlemiss, Derek N ^a   Riley, Graham J ^a   Trail, Brenda ^a   Wood, Martyn D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (METHOXYCARBAMOYL) INDOLINE DERIVATIVE; 6 METHYL 5 TRIFLUOROINDOLINE; BENZENE DERIVATIVE; BROMINE; INDOLE DERIVATIVE; METHYL GROUP; PYRAZINE; SB 247853; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY NEUROSIS; ARTICLE; DRUG BINDING; MOTOR DYSFUNCTION; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINOPYRIDINES; ANIMALS; DRUG DESIGN; INDOLES; KINETICS; MOLECULAR STRUCTURE; MOTOR ACTIVITY; RATS; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0034698794     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00365-6     Document Type: Article

References (6)

1. WO Patent 9748700, 1997