Probes for narcotic receptor-mediated phenomena. 25.1 Synthesis and evaluation of N-alkyl-substituted (α-piperazinylbenzyl)benzamides as novel, highly selective δ opioid receptor agonists

Journal of Medicinal Chemistry

Volumn 40, Issue 18, 1997, Pages 2936-2947

  Katsura, Yousuke ^a,e   Zhang, Xiaoyan ^a   Homma, Koichi ^a,f   Rice, Kenner C ^a   Calderon, Silvia N ^a,g   Rothman, Richard B ^b   Yamamura, Henry I ^c   Davis, Peg ^c   Flippen Anderson, Judith L ^d   Xu, Heng ^b   Becketts, Karen ^b   Foltz, Eric J ^c   Porreca, Frank ^c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NIDA Addiction Research Center   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d NAVAL RESEARCH LABORATORY   (United States)

^e ASTELLAS PHARMA INC   (Japan)

^f MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^g CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDE DERIVATIVE; DELTA OPIATE RECEPTOR; MU OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR;

ARTICLE; BINDING AFFINITY; BRAIN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ILEUM; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

ALKYLATION; ANIMALS; BENZAMIDES; BRAIN; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; GUINEA PIGS; HUMANS; KINETICS; MALE; MICE; MICE, INBRED ICR; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NARCOTICS; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; VAS DEFERENS;

EID: 14444285481     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970106d     Document Type: Article

References (41)

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