Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic δ opioid receptor ligands

Journal of Medicinal Chemistry

Volumn 42, Issue 26, 1999, Pages 5455-5463

  Zhang, Xiaoyan ^a,d   Rice, Kenner C ^a   Calderon, Silvia N ^a,e   Kayakiri, Hiroshi ^a,f   Smith, Larren ^a   Coop, Andrew ^a,g   Jacobson, Arthur E ^a   Rothman, Richard B ^b   Davis, Peg ^c   Dersch, Christina M ^b   Porreca, Frank ^c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NIDA Addiction Research Center   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d Neurogen Corporation   (United States)

^e CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^f ASTELLAS PHARMA INC   (Japan)

^g UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 PIPERAZINYLBENZYL) N,N DIETHYLBENZAMIDE; 4 [(4 ALLYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; 4 [(4 BENZYL 1 PIPERAZINYL)BENZYL] N,N DIETHYLBENZAMIDE; 4 [(4 PIPERIDINYLIDENE) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; GUINEA PIGS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED ICR; MOLECULAR PROBES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17544394335     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9903895     Document Type: Article

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