Anti-arthritic effect of methotrexate: Is it really mediated by adenosine?

European Journal of Pharmaceutical Sciences

Volumn 9, Issue 4, 2000, Pages 333-343

  Andersson, Sven E ^a   Johansson, Lars Håkan ^a   Lexmüller, Kristina ^a   Ekström, Gunilla M ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Adenosine; Arthritis; IL 6; Methotrexate; Polyamines; TNF

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 8 (4 SULFOPHENYL)THEOPHYLLINE; 8 [4 (2 AMINOETHYLCARBAMOYL)METHOXYPHENYL] 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; AMINOPTERIN; ANTIGEN; ANTIRHEUMATIC AGENT; CYTOKINE; DIHYDROFOLATE REDUCTASE; FLUOROURACIL; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; INTERLEUKIN 6; METHOTREXATE; PHENYLISOPROPYLADENOSINE; POLYAMINE; S ADENOSYLMETHIONINE; THYMIDYLATE SYNTHASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG MECHANISM; DRUG POTENTIATION; ENZYME INHIBITION; FEMALE; HYPOTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT; SYNOVIOCYTE;

ADENOSINE; ANIMALS; ARTHRITIS, EXPERIMENTAL; BIOGENIC POLYAMINES; CELLS, CULTURED; CYTOKINES; ENZYME INHIBITORS; FEMALE; FOLIC ACID; FOLIC ACID ANTAGONISTS; LEUCOVORIN; METHOTREXATE; RATS; RATS, INBRED STRAINS; RECEPTORS, PURINERGIC P1; SYNOVIAL MEMBRANE; THYMIDYLATE SYNTHASE;

EID: 0033958014     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(99)00073-1     Document Type: Article

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