Resolution of tethered antiparallel and parallel holliday junctions by the Flp site-specific recombinase

Journal of Molecular Biology

Volumn 296, Issue 2, 2000, Pages 403-419

  Lee, Jehee ^a   Tribble, Gena ^b   Jayaram, Makkuni ^b  

^a Jeju National University   (South Korea)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Integrase family; Resolution bias; Site specific recombination; Tethered DNA junctions

Indexed keywords

DNA; INTEGRASE; RECOMBINASE;

ARTICLE; BASE PAIRING; CROSS LINKING; GENETIC RECOMBINATION; HOLLIDAY JUNCTION; ISOMERISM; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ESCHERICHIA COLI;

EID: 0034681282     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3472     Document Type: Article

References (40)

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2. Action of site-specific recombinases XerC and XerD on tethered Holliday junctions
3. The isomeric preference of Holliday junctions influences resolution bias by lambda integrase
4. Structural analysis of the RuvC-Holliday junction complex reveals an unfolded junction
5. The geometry of a synaptic intermediate in a pathway of bacteriophage lambda site-specific recombination
6. Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases
7. The solution structure of the four-way DNA junction at low salt conditions: A fluorescence resonance energy transfer analysis
8. The structure of the Holliday junction, and its resolution
9. Structure and mechanism in site-specific recombination
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11. The integrase family of recombinases: Organization and function of the active site
12. Site-specific recombination: Synapsis and strand exchange revealed
13. Structure of Cre recombinase complexed with DNA in a site-specific recombinase synapse
14. Assymetric DNA-bending in the Cre-loxP site-specific recombination synapse
15. Molecular organization in site-specific recombination: The catalytic domain of bacteriophage HP1 integrase at 2.7 Å resolution
16. DNA-sequence asymmetry directs the alignment of recombination sites in the FLP synaptic complex
17. Mechanism of site-specific DNA inversion in bacteria
18. Construction and analysis of parallel and antiparallel Holliday junctions
19. Flexibility in DNA recombination: Structure of the Lambda integrase catalytic core
20. Mechanistic and structural complexity in the site-specific recombination pathways of Int and FLP
21. Functional roles of individual recombinase monomers in strand breakage and strand reunion during site-specific DNA recombination
22. Role of partner homology in DNA recombination: Complementary base-pairing orients the 5'-hydroxyl for strand joining during Flp site-specific recombination
23. A tetramer of the Flp recombinase silences the trimers within it during resolution of a Holliday junction substrate
24. Assembly and orientation of Flp recombinase active sites on two-, three-, and four-armed DNA substrates: Implications for a recombination mechanism
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27. Site-specific recombination caught in the act
28. The structure of the four-way junction in DNA
29. The role of DNA bending in Flp-mediated site-specific recombination
30. Swapping DNA strands and sensing homology without branch migration in lambda site-specific recombination
31. The FLP protein contacts both major and minor grooves of its recognition target sequence
32. Asymmetry in active complexes of FLP recombinase
33. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
34. Catalysis by site-specific recombinases
35. A model for the mechanism of human topoisomerase I
36. Crystal structure of the site-specific recombinase, XerD
37. The stereochemistry of a four-way DNA junction
38. Analyses of the first chemical step in Flp site-specific recombination: Synapsis may not be a pre-requisite for strand cleavage
39. A general model for site-specific recombination by the integrase family recombinases
40. A protein dissociation step limits turnover in FLP recombinase-mediated site-specific recombination