In vitro studies on L-771,688 (SNAP 6383), a new potent and selective α(1A)-adrenoceptor antagonist

European Journal of Pharmacology

Volumn 409, Issue 3, 2000, Pages 301-312

  Chang, Raymond S L ^a   Chen, Tsing Bau ^a   O'Malley, Stacey S ^a   Pettibone, Douglas J ^a   DiSalvo, Jerry ^a   Francis, Barbara ^a   Bock, Mark G ^a   Freidinger, Roger ^a   Nagarathnam, Dhanapalan ^b   Miao, Shou W ^b   Shen, Quanrong ^b   Lagu, Bharat ^b   Murali Dhar, T G ^b   Tyagarajan, Sriram ^b   Marzabadi, Mohammad R ^b   Wong, Wai C ^b   Gluchowski, Charles ^b   Forray, Carlos ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b H LUNDBECK A S   (Denmark)

Author keywords

(1A) adrenoceptor; (1A) adrenoceptor antagonist; Adrenoceptor; Adrenoceptor subtype; Prostate

Indexed keywords

2 [2 (4 HYDROXYPHENYL)ETHYLAMINOMETHYL]TETRALONE I 125; 4 (3,4 DIFLUOROPHENYL) 3,4 DIHYDRO 6 METHOXYMETHYL 2(1H) OXO 3,5 PYRIMIDINEDICARBOXYLIC ACID 5 METHYL ESTER 3 [3 [4 (2 PYRIDYL) 1 PIPERIDINYL]PROPYL]AMIDE; 4 AMINO 2 [4 BENZYLOXYCARBONYL 3 [(TERT BUTYLAMINO)CARBONYL] 1 PIPERAZINYL] 6,7 DIMETHOXYQUINAZOLINE; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; GG 818; INOSITOL PHOSPHATE; L 771688; METHYL 4 (3,4 DIFLUOROPHENYL) 6 [(METHYLOXY)METHYL] 2 OXO 3 [[[3 [4 (2 PYRIDINYL) 1 PIPERIDINYL]PROPYL]AMINO]CARBONYL] 1,2,3,4 TETRAHYDRO 5 PYRIMIDINECARBOXYLATE; N [5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 5,6,7,8 TETRAHYDRO 2 HYDROXY 1 NAPHTHYL]METHANESULFONAMIDE; NORADRENALIN; PHENYLEPHRINE; PRAZOSIN; TERAZOSIN; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; BLADDER NECK; CHO CELL; CONTROLLED STUDY; DOG; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROSTATE; PROSTATE HYPERTROPHY; RAT; RECEPTOR AFFINITY;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DOGS; HUMANS; IMIDAZOLES; MALE; PHENYLEPHRINE; PRAZOSIN; PROSTATE; PYRIMIDINONES; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; TETRAHYDRONAPHTHALENES; URINARY BLADDER;

EID: 0034672537     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00854-2     Document Type: Article

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