A rat brain na+ channel α subunit with novel gating properties

Neuron

Volumn 1, Issue 6, 1988, Pages 449-461

  Auld, Vanessa J ^a   Goldin, Alan L ^b   Krafte, Douglas S ^b   Marshall, John ^d   Dunn, James M ^a   Catterall, William A ^c   Lester, Henry A ^b   Davidson, Norman ^b   Dunn, Robert J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MEMBRANE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BRAIN; ELECTRIC CONDUCTIVITY; FEMALE; GENE LIBRARY; GENETIC TRANSCRIPTION; GENETICS; KINETICS; MACROMOLECULE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OOCYTE; PHYSIOLOGY; PLASMID; PROTEIN CONFORMATION; RAT; RAT STRAIN; RESTRICTION MAPPING; SODIUM CHANNEL; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BRAIN; DNA; ELECTRIC CONDUCTIVITY; FEMALE; GENE LIBRARY; KINETICS; MACROMOLECULAR SYSTEMS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; OOCYTES; PLASMIDS; PROTEIN CONFORMATION; RATS; RATS, INBRED STRAINS; RESTRICTION MAPPING; SODIUM CHANNELS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC; XENOPUS LAEVIS;

EID: 0024058061     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/0896-6273(88)90176-6     Document Type: Article

References (47)

1. Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of the Electrophorous electricus
2. Cloning and characterization of the gene for the a subunit or the mammalian voltage-gated sodium channel
3. Protein components of the purified sodium channel from rat skeletal muscle sarcolemma
4. 32S label as an aid to rapid DNA sequence determination
5. Molecular properties of voltage-sensitive sodium channels
6. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
7. Cyclic AMP-dependent phosphorylation ofthe a subunit of the sodium channel in synaptic nerve ending particles
8. DNA sequences procedingthe rabbit β-globin gene are required for formation in mouse L cells of β-globin RNA with the correct 5′ terminus
9. Messenger RNA coding for only the a subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes
10. The structure of the voltage-sensitive sodium channel-inferences derived from computer-aided analysis of the Electrophorus electricus channel primary structure
11. A simple and very efficient method of generating cDNA libraries
12. Molecular model of the action potential sodium channel
13. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
14. Purification of the saxitoxin receptor of the sodium channel from rat brain
15. The saxitoxin receptor of the sodium channel from rat brain: evidence for two nonidentical β subunits
16. Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing
17. Negative surface charge near sodium channels of nerve divalent ions monovalent ions and pH
18. Characterization of mRNA responsible for induction of functional sodium channels in Xenopus oocytes
19. Primary structure of rat brain sodium channel III deduced from the cDNA sequence
20. Software for electrophysiological experiments with a personal computer
21. Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat brain Na channels expressed in Xenopus oocytes
22. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
23. The Na channel frorn rat brain: role of the β1 and β2 subunits in saxitoxin binding
24. Functional properties of rat brain sodium channels lacking the β1 and β2 subunit
25. Sodium currents and sodium current fluctuations in rat myelinated nerve fibres
26. Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence
27. Existence of distinct sodium channel messenger RNAs in rat brain
28. Expression of functional sodium channels from cloned cDNA
29. High resolution two-dimensional electrophoresis of proteins
30. Purified and unpurified sodium channels from eel electroplax in planar bilayers
31. Cyclic AMP-dependent phosphorylation of voltage-sensitive sodium channels in primary cultures of rat brain neurons
32. Genomic organization and deduced amino acid sequence of a putative sodium channel gene in Drosophila
33. DNA sequencing with chain terminating inhibitors
34. Biosynthesis and processing of the α subunit of the voltage-sensitive sodium channel in rat brain neurons
35. Palmitylation, sulfation, and glycosylation of the a subunit of the sodium channel: role of post-translational modification in channel assembly
36. A large intracellular pool of inactive Na channel α subunits in developing rat brain
37. Multiple potassium-channel components are produced by alternative splicing at the Shaker locus of Drosophila
38. Patch clamp characterization of sodium channels expressed from rat brain cDNA
39. Partial purification and functional expression of brain mRNAs coding for neurotransmitter receptors and voltage-operated channels
40. Functional expression of cloned cDNA encoding sodium channel III
41. Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes
42. Fluorescence assay for neurotoxin-modulated ion transport by the reconstituted voltage-activated sodium channel isolated from eel electric organ
43. Localization of sodium hannel in axon hillocks and initial segments of retinal ganglion ells
44. Efficient isolation of genes using antibody probes
45. Yeast RNA polymerase II genes: isolation with antibody probes